G.M. Sequeira's research while affiliated with Manukau Institute of Technology and other places
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Publications (5)
Objective: Cancer cachexia is defined as: a ‘multifactorial syndrome’, and it has been suggested that a multitargeted approach is required in its management. High prevalence is seen within non-small cell lung cancer, and patients may continue to experience cachexia post end of anti-cancer treatment, and in the late/end stage.Material and Methods: P...
Background
Cancer cachexia is a condition often seen at diagnosis, throughout anti‐cancer treatments and in end‐stage non‐small‐cell lung cancer patients.
Methods and results
Participants with late‐stage non‐small‐cell lung cancer and cachexia (defined as ≥5% weight loss within 12 months) were randomly assigned 1:2 to 2.09 g of eicosapentaenoic ac...
The aim of this study was to determine the effect of ischemic preconditioning (IPC) on several measures of aerobic function and 4-km cycling time-trial performance. An acute cross-over design was adopted involving eight well-trained cyclists (age 27.0 ± 7.0 years) who completed incremental and square-wave exercise tests for determination of peak O2...
Background: Cancer Cachexia (CC) is a common problem seen in many advanced malignancies including Non- Small-Cell Lung Cancer (NSCLC). In CC there is a significant loss of adipose tissue and skeletal muscle mass. Muscle wasting is the main cause of impaired function, leading to respiratory complications and fatigue. The optimal treatment for CC is...
Background: Cancer Cachexia (CC) is a common problem seen in many advanced malignancies including Non- Small-Cell Lung Cancer (NSCLC). In CC there is a significant loss of adipose tissue and skeletal muscle mass. Muscle wasting is the main cause of impaired function, leading to respiratory complications and fatigue. The optimal treatment for CC is...
Citations
... A trimodal approach is usually the preferred treatment studied in this population, which includes a combination of exercise, nutritional supplementation, and nonsteroidal anti-inflammatory drugs. The study ACCeRT was a small prospective trial in which 20 adult patients with nonsmall-cell lung cancer (NSCLC) and refractory cachexia were randomized to receive EPA and celecoxib or EPA, celecoxib, essential amino acids, and RT [85,86]. Interventions in both arms were feasible, and stabilization of body weight and free fat mass could be obtained for some weeks with both approaches [85]. ...
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... The precise mechanisms through which IPC might induce such ergogenic effects remain unclear; however, several findings suggest that its positive effect on endurance performance may be due to increased local vasodilation [6], blood flow [7], and O 2 uptake [8], as well as decreased lactate accumulation [9]. ...
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... Indeed, topics include randomized trials such as the Auckland's Cancer Cachexia evaluating Resistance Training (ACCeRT) trial that evaluated the effects of eicosapentaenoic acid and celecoxib vs. eicosapentaenoic acid and celecoxib plus progressive resistance training followed by ingestion of essential amino acids high in leucine in patients with non-small cell lung cancer. 13 Other studies also cover aspects of nutritional intake like omega-3 and omega-3/curcuminenriched fruit juices 1 and their effects on muscle wasting or the effects of a leucine-rich diet in tumour-bearing animals. 4 Klose et al. studied stem cell activation, 2 whereas Alves et al. and Bekki et al. studied different aspects of exercise training in animal models. ...
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