G.M. Alink's research while affiliated with Wageningen University & Research and other places

Publications (12)

Article
Full-text available
The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bioaccumulation of the nonbiodegradable nanoscale particles in a biological system and are a cause for concern....
Article
Full-text available
The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bioaccumulation of the nonbiodegradable nanoscale particles in a biological system and are a cause for concern....
Poster
Full-text available
In a comparative study with ferric oxide nano- and fine particles (hematite: <100 nm and <2.5 μm), arsenopyrite (<5 μm), titanium dioxide (TiO2) (<50 nm), and pure quartz (DQ12) (<2.5μm) particles, the toxicity of the different particles and the underlying mechanisms were investigated.
Article
Full-text available
KEYWORDS Fibers; metals; gene expression; oxidative stress; cancer ABSTRACT Exposure to ambient air pollution (particles, fibres) is associated with pulmonary diseases and cancer. The mechanisms of induced health effects are believed to involve inflammation and oxidative stress. Oxidative stress mediated by airborne particles and/or fibres may aris...

Citations

... However, numerous studies have shown that ION can actually trigger multiple effects that would compromise the cellular homeostasis (reviewed in Patil et al. [223] and Valdiglesias et al. [310]). Several reports have evaluated cytotoxicity caused by bare and differently coated ION (maghemite and magnetite) exposure, linking this effect to mitochondrial dysfunction due to membrane physical damage or membrane depolarization [31,56,128,132,141,261,279]; to dose-and timedependent ROS production [31,97,114,121,141,162,209,269,279,356]; or to inactivation of antioxidant enzymatic systems, glutathione depletion, and oxidative stress generation [4,26,78,89,97,125,169,326,363]. Other forms of cytotoxicity reported after ION exposure include cell cycle alterations [20,158,231,334], cytoskeleton alterations [61,335,336], disruption of mitochondrial membrane potential [78,140,261,279], plasmatic membrane impairment [245,327], apoptosis/necrosis [5,28,145], autophagy [74,265,275], and decreases in cell integrity or viability [18,59]. ...
... Some researchers stated the concentrations of nanoparticles intended for investigation of the occupational health effects should be selected the same as exposure concentrations in occupational workplace hazards (Bhattacharya et al., 2012). A group of researchers employed Multiple Path Particle Dosimetry software (MPPD, version 2.1 for NPs, supported by Applied Research Associates Inc., Raleigh, NC) to estimate the depleted concentration in alveolus due to occupational exposure revealed that the optimal concentration of nanoparticles in the occupational workplace for in vitro study was in the range of 30-400 mg/ml (Gangwal et al., 2011). ...
... Excessive radical production and/or decreased antioxidants may lead to a condition called oxidative stress (14). Oxidative stress significantly impact multiple cellular pathways, that can lead Bas (16) and oxidative deterioration of poly unsaturated lipid that lead to lipid peroxidation (17), thus malondialdehyde (MDA) a lipid peroxidative product is used as an indicator of oxidative stress in cell and tissues. Hydrogen peroxide is one of the primary oxidants in biological system, it is lipid soluble and thus able to diffuse easily through biological membrane and reacting other cellular compartments, and induces damage to the cell membrane and decrease cell viability, furthermore, producing cellular injury especially if it become converted to the highly reactive OH ( 18,19). ...