G Oudemans's research while affiliated with University of Otago and other places

Publications (19)

Article
Taenia hydatigena and Echinococcus granulosus in dogs have been used as a model to evaluate the response of these parasites to increasing doses of mebendazole in different dose forms (powder, micronized powder and tablets of micronized powder). Overall the micronized powder proved to be the most active, the tablets less so and the normal powder lea...
Article
Cysts found in the liver of a horse which had never been out of New Zealand were used to infect two dogs which were slaughtered 35 days after infection. Large numbers of Echinococcus granulosus were recovered. These cestodes were compared with mature dog-sheep cestodes, using light and scanning electron microscopy and identified as the dog-horse st...
Article
Dogs infected with Echinococcus granulosus were treated with praziquantel by three routes and at different dosage rates. The results indicated that the dog was of similar efficacy when administered by the oral and intramuscular routes, but less effective by the subcutaneous route.
Article
Tablets of micronised nitroscanate (nominal particle size 2--3 microns) were given to a total of 190 dogs that had been experimentally infected with either Echinococcus granulosus or Taenia hydatigena. The efficiency of the drug in tablet form in freeing dogs from tapeworms, was investigated. The dose rate at which 50 per cent of normally fed dogs...
Article
Trials with oxfendazole carried out on 120 dogs infected with either Echinococcus granulosus or Taenia hydatigena indicated that a single treatment significantly reduced the proportion of dogs infected with tapeworms. Diarrhoea occurred occasionally when the dose rate exceeded 20 mg/kg.
Article
A limited, but controlled trial with mebendazole incorporated in a prepared food and with tablets given with this food showed that with the former there was an overall reduction in the expected dog population harbouring Echinococcus granulosus and Taenia hydatigena. Neither treatment was fully effective.
Article
Diuredosan has been tested against Echinococcus granulosus and Taenia hydatigena infections in dogs. The drug showed significant activity against T hydatigena, but there was no significant dose response curve against E granulosus in this trial. Two treatments at 50 mg/kg or 100 mg/kg, however, reduced the number of dogs infected with hydatid worms....
Article
The effect of an antibiotic of the streptothricin class on Echinococcus granulosus and Taenia hydatigena infections has been investigated in a trial involving 160 dogs. The drug showed significant activity in freeing dogs from Thydatigena, but the evidence for similar activity against E granulosus was less well marked. Vomiting and diarrhoea were c...
Article
The lethal effect of some benzimidazoles on Taenia hydatigena infections in dogs have been compared. Fenbendazole, parbendazole and oxibendazole were more effective than cambendazole and thiabendazole, while coarsely ground mebendazole did not differ significantly from any of them.
Article
The effect of praziquantel on Echinococcus granulosus, Taenia hydatigena and T ovis was investigated in a trial involving 360 dogs. The drug was found to be highly toxic to tapeworms. Few dogs remained infected after a single treatment within the range of dose rates tested (0-31 mg/kg to 10-0 mg/kg body weight). No toxicity to dogs was observed.
Article
Trials with micronised nitroscanate carried out on 170 dogs infected with either Echinococcus granulosus or Taenia hydatigena indicated that a single treatment at 62-5 mg/kg and 16 mg/kg respectively significantly reduced the proportion of dogs infected with tapeworms. Some evidence is presented that micronisation may give a fourfold increase in th...
Article
The effect of niclosamide (particle size 1 micron m) and its piperazine salt (particle size 5-10 micron m) on Echinococcus granulosus and Taenia hydatigena has been investigated. The piperazine salt of niclosamide was also tested for activity against Taenia ovis. These trials involved 326 dogs. Irrespective of particle size, the drug was found to b...
Article
Trials with nitroscanate carried out on 186 dogs infected with either Echinococcus granulosus or Taenia hydatigena indicated that a single treatment at a dose rate of 1000 mg/kg or two treatments at 250 mg/kg eliminated the former, but a single treatment at 64 mg/kg was sufficient to eliminate the latter. At this dosing schedule, vomiting and diarr...
Article
Trials with fospirate carried out with 170 dogs infected with either Echinococcus granulosus or Taenia hydatigena indicated that a dose rate of 40 mg/kg given on three occasions and 10 mg/kg given on one occasion eliminated each species, respectively. Increasing the dose rat substantially above 40 mg/kg did not reduce the number of treatments requi...
Article
ExtractTheoretically, the life-cycle of the sheep metacestodes with their strobilate phase in dogs permits combinations of at least three methods of control. These are the prevention of dogs gaining access to larval cestodes, the chemical elimination of the strobilate and or the larval stage in the appropiate hosts, and the immunization of either t...
Article
Trials with bithionol sulphoxide involving 130 dogs, infected with either Echinococcus granulosus or Taenia hydatigena, indicated that a single treatment at a dose rate of 400 mg/kg or two treatments at 50 mg/kg eliminated the former, but a single treatment at 50 mg/kg was sufficient to eliminate the latter. Dose rates 200 mg/kg or more were lethal...

Citations

... Oxfendazole is a benzimidazole drug which has been used in veterinary medicine to control nematode infections and was found to be effective against the intestinal stage of E. granulosus, as well as other cestodes in the gastrointestinal tract, thus could be used to treat infections in dogs, the principal reservoir for human infection (Gemmell et al., 1979). Gonzales et al. (1996) examined the effect of the drug on the tissue stage of tapeworm infections and found that a single dose of 30 mg/kg of body weight of oxfendazole in pigs completely eliminated all tissue cysts of Taenia solium, a medically important human tapeworm. ...
... Because we found no differences in the uncoupling properties of NENS vs. Nic and similar effects in whole animal metabolic testing, the FDA approved form of niclosamide would be an ideal drug to undertake human clinical trials in obese humans with T2D. Nic has an excellent safety profile in humans, dogs and rodents and generally accumulates in the liver thus reducing potential off target effects 19,[37][38][39][40][41] . However, future human research studying the chronic effects of niclosamide would need to carefully study the hypoglycaemic risk 42 , hypolipidaemic 43 , and lipid synthesis 44 effects of inhibiting glucagon signalling in the liver. ...
... και Echinococcus spp. (Gemmell et al. 1977, Andersen et al. 1978, Andersen et al. 1979, ενώ η επσιπραντέλη υπολείπεται τουλάχι στον κατά των προνυμφικών μορφών του Echinococcus spp., γεγονός που επιβάλλει την ενίσχυση του δοσολογικοΰ της σχήματος, όπως προτείνεται στον πίνακα 2 (Arm et al. 1990, Corwin et al. 1991, Thompson et al. 1991, Eckert et al. 2001). ...
... To develop and evaluate public health control interventions against Echinococcus granulosus, it is imperative to understand the reaction of the transmission system on the interventions. Mass dog treatment programs are widely applied in practice to control or eradicate Echinococcus granulosus [8, 11, 20, 23]. ...
... The low and insufficient bioavailability attributed to the poor water solubility of drugs, especially for those of biopharmaceutical classification system class II (which exhibit low solubility but high permeability), can be improved by increasing the solubility or the dissolution rate of the active pharmaceutical ingredients in gastrointestinal fluids. Several practical methods have been applied to increase the solubility and availability of MBZ, such as preparation of solid dispersions (11,12), crystal engineering (13), self-microemulsifying drug delivery systems (14), micronization (15), N-substitution (10), etc. Many published research papers suggest that the bioavailability of MBZ is indeed an important issue. ...
... Tapeworms of canids (especially Echinococcus and Taenia spp.) are the only intestinal parasites that have so far been controlled, with variable success, by adopting intensive anthelmintic treatment programs with praziquantel. Praziquantel is highly efficient, eliminating 99-100 % of the Echinococcus burdens (Gemmell et al., 1980). Mass praziquantel treatment of dogs, combined with an intensive education program, was a major successful control strategy against cystic echinococcosis in New Zealand, Tasmania, and parts of Cyprus . ...
... Results found by Tanda were remarkable because in Sardinia horses were bred wild or in the same pastures with sheep, cattle, goats, and pigs, all animal species that showed high percentages of CE. This epidemiological situation was very similar to that highlighted by Williams and Sweatman (1963) in New Zealand, where CE in horses was rare (Bowie et al. 1984), even if these animals were often bred together with sheep. In 1967, Macchioni and Gallo (1967) carried out the first experimental infection of E. granulosus equinus in dogs and rodents and a morpho-biological characterization of the adult parasite. ...