September 2010
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2 Citations
Bulletin des Sociétés Chimiques Belges
Dihydropyrazines have been found to condense easily and in good yields with carbonyl compounds. 2,3-Dihydropyrazines were treated with aliphatic, terpenic, aromatic and furan aldehydes and with aliphatic and alicyclic ketones leading to trisubstituted pyrazines. When α, β-unsaturated carbonyl compounds are used the formation of 6,7-dihydro-5E-cyclopenta [b] pyrazines is observed. When autocondensation of α-aminoacetone is conducted in the presence of aldehydes these compounds react immediately with the intermediate 3,6-dihydropyrazine to give trisubstituted pyrazines.