G. Kemmler's research while affiliated with University of Innsbruck and other places

Publications (177)

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Objectives To develop a cancer-specific multi-attribute utility instrument derived from the Functional Assessment of Cancer Therapy - General (FACT-G) health-related quality of life (HRQL) questionnaire. Methods We derived a descriptive system based on a subset of the 27-item FACT-G. Item selection was informed by psychometric analyses of existing...
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Objective To develop Austrian, Italian, and Polish general population value sets for the EORTC QLU-C10D, a cancer-specific utility instrument based on the EORTC QLQ-C30, and to descriptively compare their index scores for distinct health states.Methods The QLU-C10D descriptive system comprises 10 health attributes and each can take on 4 levels. A s...
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Background: The EORTC QLU-C10D is a new multi-attribute utility instrument derived from the widely used cancer-specific quality-of-life (QOL) questionnaire, EORTC QLQ-C30. The QLU-C10D contains ten dimensions (Physical, Role, Social and Emotional Functioning; Pain, Fatigue, Sleep, Appetite, Nausea, Bowel Problems), each with four levels. To be used...
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Objective: The impact of religious/spiritual activities on clinical outcomes in patients with serious mental illnesses remains controversial, which was addressed in this international cross-sectional study. Method: Three-hundred sixty-nine subjects were recruited from Austria (n = 189) and Japan (n = 180), consisting of 112 outpatients with para...
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Background: Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients. Methods: Fifty-two patients with schizophrenia and 60 patients suffering from BD...
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Introduction Suicidal ideation has repeatedly been reported as a predecessor of suicidal behavior. Several neuropsychological parameters have been associated with suicidal ideation. Emotional intelligence (EI) and resilience, which play an important role in the emergence of psychiatric disorders may also be related with suicidality. Objectives The...
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Introduction Psychiatric patients constitute a high-risk population for suicide. In-patient status and the period after discharge are of particular interest concerning risk assessment. Objective To assess risk factors for in-patient and post-discharge suicides. Methods The Tyrol suicide register was linked with the registers of three psychiatric...
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Introduction Study results on decision-making (DM) abilities in suicidal individuals are conflicting. Most studies have focused on DM under ambiguity and included patients with a lifetime history of suicide attempts. Objective To assess DM abilities with two different instruments in recent suicide attempters. Methods The study sample consisted of...
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BackgroundBMI has been suggested to impact on estrogenic activity in patients receiving anastrozole resulting in a reduced treatment efficacy in obese women. Current evidence in this regard is controversially discussed. Since estradiol is inversely correlated with gonadotropins it can be assumed that an impact of BMI is also reflected by gonadotrop...
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Background: The different patterns of Emotional Intelligence (EI) deficits in schizophrenia and bipolar I disorder are are not yet well understood. This study compares EI levels among these groups and highlights the potential impact of non-social cognition on EI. Method: Fifty-eight schizophrenia and 60 bipolar outpatients were investigated usin...
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Objective: Improving quality of life (QoL) is an important objective in the treatment of schizophrenia. The aim of the current study was to examine to what extent resilience, self-esteem, hopelessness, and psychopathology are correlated with QoL. Method: We recruited 52 out-patients diagnosed with schizophrenia according to DSM-IV criteria and 7...
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Purpose To derive a health state classification system (HSCS) from the cancer-specific quality of life questionnaire, the EORTC QLQ-C30, as the basis for a multi-attribute utility instrument. Methods The conceptual model for the HSCS was based on the established domain structure of the QLQ-C30. Several criteria were considered to select a subset of...
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To assess the feasibility of using a discrete choice experiment (DCE) to value health states within the QLU-C10D, a utility instrument derived from the QLQ-C30, and to assess clarity, difficulty, and respondent preference between two presentation formats. We ran a DCE valuation task in an online panel (N = 430). Respondents answered 16 choice pairs...
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Hintergrund Mentale Aktivitäten können möglicherweise die Entwicklung einer demenziellen Erkrankung verzögern oder deren Verlauf positiv beeinflussen. In dieser Studie wurde der Einfluss von verschiedenen Bereichen der mentalen Aktivität auf kognitive Funktionen bei Patienten einer Gedächtnissprechstunde untersucht. Material und Methoden Bei 191 P...
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INTRODUCTION: Mental activities have been suggested to influence the risk and course of dementia. This study was performed in order to assess the association of various mental activities with diagnosis and cognitive functions in an elderly population. METHODS: A total of 191 memory clinic patients (mean age 71.7 ± 10.7 years) were included in this...
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Summary: This paper investigates whether results of the Medical Studies Aptitude Test (EMS), the official admission test for medical studies in Austria and Switzerland, are influenced by applicants’ personality traits and/or emotional intelligence (EI). Description: Medical schools worldwide are required to select students from a growing pool of ap...
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Purpose Physical, cognitive, and social leisure activities are associated with a lower conversion to dementia. We examined whether single components of thirteen physical, five cognitive, and six social activities, or their combined effect are related to non-conversion or performance in episodic or verbal memory, executive functioning, and language....
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Objective: Increased serum homocysteine and low folate levels are associated with a higher rate of conversion to dementia. This study examined the influence of vitamin B12/folic acid intake on the conversion from mild cognitive impairment (MCI) to dementia. Participants: A community dwelling cohort of older adults (N=81) from the Vienna Transdan...
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Objectives: Multidimensional geriatric assessment (MGA) is essential in individualized treatment decisions in the elderly. The goal of this pilot study was to analyze the impact of age, sex and possibly gender on assessment status in senior cancer patients. Materials and methods: An MGA consisting of 12 scores was applied in 111 patients (range 60-...
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Background: Estrogens play a crucial role in breast carcinogenesis and progression. The third-generation aromatase inhibitors (AIs) have therefore become the first choice endocrine drugs for post-menopausal women with breast cancer, since they present greater efficacy when compared with tamoxifen. However, mode of action, side effects and tolerabil...
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A cross-sectional study was conducted in participants with schizophrenia to explore a potential association between the patients' remission status and neurocognitive functioning and to examine whether these factors have an impact on functional outcome. Psychopathological symptoms were rated by means of the Positive and Negative Syndrome Scale with...
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Disturbed interactions with one's body and with other persons are two major features in eating disorders. This study was designed to assess current and childhood characteristics of eating-disordered men. The authors interviewed 32 men with eating disorders (anorexia nervosa: N=9, bulimia nervosa: N=15, eating disorders not otherwise specified: N=8)...
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Background: Long term treatment regimen with significant side effects may diminish a patient's quality of life (QOL) and consequently undermine adherence. Endocrine treatment for breast cancer causes various side effects, which can lead to early discontinuation of this effective therapy. Current knowledge on patients’ quality of life (QOL) impairme...
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Introduction: Within an ongoing project of the EORTC Quality of Life Group, we are developing computerized adaptive test (CAT) measures for the QLQ-C30 scales. These new CAT measures are conceptualised to reflect the same constructs as the QLQ-C30 scales. Accordingly, the Fatigue-CAT is intended to capture physical and general fatigue. Methods: The...
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Allogenic haematopoietic stem cell transplantation (HCT) has become an effective therapy in patients with various haematological malignancies. GvHD is known to be a major complication in this patient group and is assumed to have a major impact on patients' quality of life (QOL). Patients after BMT or transplantation of mobilized PBSCs were consider...
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The cultural and ethnic background of a patient may have a significant impact on the presentation of a psychiatric disorder. In this study symptoms assessed within a major depressive episode in 3 groups of female patients were compared: 1. women of Austrian origin, 2. women of Turkish origin but living in Austria and 3. Turkish women living in Turk...
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This prospective, naturalistic study investigated the factors influencing physicians' choice of antipsychotic drug therapy in the treatment of patients with schizophrenia. 108 in- and outpatients treated at the Department of Psychiatry of the Medical University Innsbruck who started treatment with a new generation antipsychotic (except clozapine) w...
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Empirical investigation of formerly proposed criteria for relevant changes of health-related quality of life (QOL) regarding their use for monitoring changes in the individual patient. Suggestion of a new criterion trying to overcome the drawbacks of former criteria. QOL data were collected longitudinally in 160 cancer patients receiving chemothera...
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Geriatric assessment (GA) must be integrated into treatment concepts for elderly cancer patients. Aim of this study was to assess the coverage of a large battery of GA instruments by determining the number of independent domains measured. Thirteen different GA scores were applied in 78 elderly tumor patients (mean age 72.9 years). Data were analyze...
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Depression and impaired quality of life (QoL) are frequently observed in patients suffering from HIV-infection. As an enhanced degradation of the serotonin precursor tryptophan is well documented in HIV-infected patients, disturbances in tryptophan metabolism may be causally linked to HIV-related depression. In this study, the relationship between...
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Bulimia nervosa (BN) is often associated with depressive symptoms and treatment with antidepressants has shown positive effects. A shared deficient serotonergic transmission was postulated for both syndromes. The left dorsolateral prefrontal cortex was argued to regulate eating behaviour and to be dysfunctional in eating disorders. Fourteen women m...
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In this prospective study, patients with schizophrenia were followed up for 3 months to investigate the impact of sociodemographic factors, psychopathology, change in psychopathology and side effects on subjective response and attitudes toward antipsychotics during the initial treatment period. We investigated 42 patients starting treatment with a...
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Background: Outcome in schizophrenia is multidimensional and consists of clinical and psychosocial domains. Difficulties in affect recognition are a hallmark of schizophrenia, but there is little research investigating the consequences of this deficit on patients' psychosocial status. Aims: This cross-sectional study examined the relationship of fa...
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We compared stable patients with schizophrenia who were treated with either amisulpride or olanzapine in terms of symptomatic outcome, neurocognitive functioning, functionality, and subjective outcome. Sixty outpatients with chronic schizophrenia who had been treated with either amisulpride or olanzapine for at least six months were investigated. T...
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To investigate the equivalence of the European Organization for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) and the Functional Assessment for Cancer Therapy-General (FACT-G) on the basis of corresponding subscales, and where appropriate to derive a scheme for converting QLQ-C30 scores into FACT-G scores and vice versa for us...
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With use of a randomized study design, quality of life (QOL) and physical symptoms of opioid addicts at admission were compared with slow-release oral morphine, methadone, and sublingual buprenorphine maintenance program participants after 6 months of treatment. The study was conducted from February to July 2004 in the outpatient drug user treatmen...
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Impairments of memory are often found after rupture and repair of aneurysms leading to a basal forebrain lesion. This open study investigated whether cholinergic substitution therapy may be a treatment option. The effect of donepezil, a cholinesterase inhibitor on memory functions was tested in an open-label, exploratory study in 11 patients with a...
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Aims: To establish the extent to which addicts used opioids, benzodiazepines, ethanol, cocaine and amphetamines, and to define the pattern of such use over time. Design: A retrospective analysis of data of 42.610 analyses from urinalysis screening between 2000 and 2003. Measurements: Analytical techniques used included enzyme-multiplied immunoassay...
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We compared the gender differences in health-related quality of life (QOL) on admission to a maintenance program. 103 opioid users (65 men and 38 women) admitted to a maintenance treatment program during 2000-2002 were studied. During this period we assessed the QOL status using the German version ('Berlin Quality of Life Profile') of the Lancashir...
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Objective: The overall objective of this study was to investigate how adolescents evaluate drug prevention by school, friends and mass media taking also into account regional differences. Methods: A secondary school age population (regular age 14 - 15 years) of North and South Tyrol was investigated for the study. For the elaboration of the questio...
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Measurement of biological parameters in the cerebrospinal fluid (CSF) is of great importance for diagnosis of dementia. The aim of the present study was to measure 3 important biomarkers in CSF of Alzheimer's patients: beta-Amyloid (1-42) (Aβ42), total-Tau and phospho-Tau-181. In comparison, samples from patients with frontotemporal lobe dementia,...
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Background: In the course of their disease, cancer patients sometimes suffer from psychiatric symptoms. Rates of psychiatric diagnoses in this patient group range from 6% to 40%. The most frequently reported symptoms belong to syndromes of depression and anxiety. Depressive syndromes have been shown as key variables causing an impairment in quality...
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In order to study alterations of glucose metabolism we conducted a prospective investigation on patients with the diagnosis of schizophrenic disorder (ICD 10) who received either amisulpride or clozapine We included 22 patients. Eleven of them received clozapine; their mean age was 37.4 (±8), four of them were male and seven female. Eleven patients...
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Temporary intraventricular catheters for managing acute obstructive hydrocephalus caused by intraventricular haemorrhage carry a high risk of developing ventriculostomy-related ventriculitis (VRV). The aim of this prospective study was to validate a new parameter for the early detection of an intraventricular infection. Patients with external ventr...
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To develop and test a questionnaire for measuring quality of life in patients with craniocervical dystonia. A 29-item pool was developed based on semi-structured interviews of patients with cervical dystonia (CD) and blepharospasm (BSP). This preliminary questionnaire was administered to 203 consecutive patients with CD and BSP from Austrian dyston...
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Repetitive transcranial magnetic stimulation (rTMS) has been reported to demonstrate slight effects in the treatment of depression. Hence, a novel bilateral versus unilateral and sham stimulation design was applied to further assess rTMS' antidepressant effects. Forty one medication free patients with major depression, admitted to a psychiatric uni...