G B Egorova's research while affiliated with Research Institute of Eye Diseases and other places

Publications (38)

Article
Full-text available
V.V. Averich, A.V. Volzhanin, G.B. Egorova Krasnov Research Institute of Eye Diseases, Moscow, Russian Federation Aim: to evaluate keratotopography of the anterior and posterior corneal surfaces in the early postoperative period following sinus trabeculectomy (STE). Patients and Methods: the study included 45 patients (45 eyes) with primary open...
Article
Full-text available
V.V. Averich, G.B. Egorova Research Institute of Eye Diseases, Moscow, Russian Federation The review presents the basic concepts of the wavefront, ocular aberrations and their changes in keratoconus (KC) — the most common form of primary ectatic corneal disorder. It also considers the issues of the posterior corneal surface impact on the indicato...
Article
Full-text available
I.A. Bubnova, G.B. Egorova, V.V. Averich, T.S. Mitichkina Scientific Research Institute of Eye Diseases, Moscow, Russian Federation Aim: to assess the changes in precorneal tear film in patients with keratoconus after corneal cross-linking (CXL). Patients and Methods: 16 patients (17 eyes) were enrolled. Keratoconus stage 1 was diagnosed in 4 ey...
Article
Bandage therapeutic-optical keratoplasty (BTOK) is one of the modern methods of surgical treatment of keratoconus (KC) that allows to improve visual functions by changing keratotopographic and pachymetric parameters of the cornea in the zone of ectasia. Long-term results show that changes also affect the central part of the cornea, which tends to f...
Article
The cytotoxic effect of an antiglaucoma preparation Prolatan containing benzalkonium chloride was studied in comparision to benzalkonium chloride itself, a lacrimer Stillavit, and their combination on the culture of the human corneal limb cells. It was found that the cytotoxicity of the antiglaucomatous preparation Prolatan on short terms of incuba...
Article
Full-text available
The aim of the study was to suggest the interpretation of confocal microscopy findings based on their comparison with a corneal morphological picture, and in accordance with the structural principles of confocal images. Materials and Methods. For 10 year (2005-2015) we monitored and followed up 660 patients with stage I-IV keratoconus (1268 eyes)....
Article
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Evaluation of morphological changes and level of light scattering of the cornea in glaucoma patients by confocal corneal microscopy Egorova G.B., Averich V.V. Scientific Research Institute of Eye Diseases, Moscow Aim: to assess morphological changes and the level of light scattering of the cornea in glaucoma patients with noncompensated IOP witho...
Article
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The article reviews the particularities of development and pathogenesis of secondary dry eye syndrome (DES) after refractive surgeries including a complex of problems related to changes in tear film content, damage of eye surface and neurotrophic epitheliopathy. Additionally, modern algorithms of treatment and prevention of secondary DES in patient...
Article
Purpose: to assess the possibilities of reducing the cytotoxic effect of benzalkonium chloride (a preservative used in ophthalmic hypotensive drugs) with the help of tear replacement therapy. Material and methods: The study included 28 patients (56 eyes) who had been using antiglaucomatous drugs containing benzalkonium chloride as a preservative...
Article
Full-text available
Keratoconus is an ophthalmological pathology which is manifested in noninflammatory conical protrusion of the central part of the cornea. Its etiology is still unknown and pathogenesis is poorly explored. There are number of reports supporting either genetic, metabolic, immunological, endocrinological, or ecological theories with several evidences...
Article
Full-text available
Purpose: to describe our experience in Acanthamoeba keratitis diagnostics and treatment in the FGBNU Research Institute of eye diseases, Moscow.Patients and Methods. We observed 24 patients (25 eyes) with the Acanthamoeba keratitis (AK). The age ranged from 18 to 47 years. All patients, except one, were contact lenses wearers. Clinical signs includ...
Article
Aim: To assess the effect of light scattering in the corneal epithelium on densitometric brightness of the stroma through mathematical modeling of the interaction between a light beam and the two-layer epithelium-stroma system. Material and methods: In order to study the scattering behavior of a plane-parallel non-coherent beam at the epithelium...
Article
The article discusses surgical options currently available for different stages of keratoconus. Indications and possible complications of each method are described in detail. So called intralamellar bandage keratoplasty, a new surgical procedure developed in the Research Institute of Eye Diseases and aimed at stabilizing the disease, is presented....
Article
Objective: To assess opportunities for the use of cyclosporine emulsion 0.05% for the treatment of dry eye syndrome in long-term contact lens wearers. Material and methods: A total of 25 long-term contact lens wearers (50 eyes) with signs of dry eye syndrome and corneal epitheliopathy of different degree, unresponsive to conventional artificial...
Article
Purpose: To evaluate the efficacy of corneoprotective agents (Corneregel and Solcoseryl) in contact lens users. Material and methods: A total of 66 long-term contact lens wearers with dry eye symptoms and varying degrees of corneal epitheliopathy were monitored. All patients used artificial tears, which, however, were not effective enough to sup...
Article
The article observes the application experience of modern methods of corneal refraction and structure evaluation. Comprehension of computer-assisted videokeratography is high enough to diagnose corneal astigmatism, keratoconus, early-stage corneal dystrophies, and corneal topography changes resulting from a variety of factors. Scanning projecting k...
Article
Up-to-date methods for diagnosis and monitoring of keratoconus are reviewed. Main advantages and drawbacks in early keratoconus diagnosis are analyzed for such methods as videokeratography, ultrasound corneal pachymetry, aberrometry, scanning projection corneal topography, confocal microscopy.
Article
Diagnostic value of confocal microscopy in subclinical corneal ectasia is analysed. Morphological changes were revealed in 71.2% of cases with subclinical keratoconus. Results of the study let us reveal typical morphological abnormalities in subclinical keratoconus, although these changes are not specific for this condition. The method is also not...
Article
Potential of impression cytology in diagnosis and evaluation of efficacy of pharmacological correction of dry eye syndrome (DES) associated with contact lens wearing was studied. When wearing contact lenses for a long time DES with tear film instability and reduction of tear production occurs in more than 50% patients. Morphological changes of epit...
Article
Full-text available
New potentials of improved tearscopy technique based on photoregistration of colour interference phenomenon are presented. A new softwear "Lacrima" was developed in order to objectivate the results and to get more detailed data, it allows to reveal data on lipid layer thickness (LLT), estimate relative area of examined zone (in %) with certain LLT...
Article
Comparative analysis of functional results of contact lens correction and penetrating keratoplasty (PKP) in keratoconus are presented. To assess resolution ability we considered visual acuity and contrast sensitivity. 117 patients (219 eyes) with stage I-IV keratoconus, wearing rigid gas-permeable contact lenses (RPCL), and 60 patients (64 eyes) af...
Article
Comparative analysis of optic aberrations in contact lens correction and after penetrating keratoplasty (PKP) in keratoconus are presented. 117 patients (219 eyes) with stage I-IV keratoconus, wearing rigid gas-permeable contact lenses (RPCL), and 60 patients (64 eyes) after PKP were examined using OPD Scan (NIDEK, Japan) to assess aberration chara...
Article
The paper presents the results of a comparative study of corneal morphological changes by lifetime confocal miscroscopy in the long-term use of various types of contact lenses (CLs). Twenty-two patients (44 eyes) were examined, of them 8 patients (16 eyes) had worn soft CLs (SCLs) for 10-25 years (mean 17 years). 8 (16 eyes) had used hard CLs (HCLs...
Article
The paper presents the results of life-time confocal microscopy using a Confoscan-4 confocal microscope (Nidek). The study was conducted on 10 healthy volunteers (20 eyes), which evaluated the specific features of the normal morphological pattern of the cornea. The morphological features of three types of anterior corneal epithelial (basal, wing, a...
Article
The paper presents the results of studying morphological changes in keratoconus by life-time confocal microscopy. A total of 50 patients (100 eyes) with grades 1-to-4 keratoconus were examined. The most pronounced changes were found in the corneal areas involved in an ectatic process. Four grades of epitheliopathy were conventionally identified in...
Article
A study aimed at assessing the efficiency of presbyopia correction by bifocal contact lenses (BCL) was undertaken; it envisaged a comprehensive evaluation of subjective data provided by patients and measurements of a number of functional parameters of the visual quality for far and near, including mono- and binocular measurements with BCL of differ...
Article
The accuracy of fixation topogometry that allows to assess the form of the cornea along its whole surface has been studied experimentally. For this purpose, a special metallic standard with a mirror surface has been manufactured, representing a paraboloid of rotation (by the formula Y2 = 2RX, where R = 7.7 mm). The standard was fixated on a face su...
Article
The paper analyses results after examination of 276 patients (495 eyes) with different types of rigid and soft contact lenses. A study of some ways for improvement of contact lens tolerance has shown that improvement of rigid contact lenses can be achieved both by perfection of their construction (in particular by using spherotoric rigid lenses) an...

Citations

... Following the initial damage by noxae, inflammatory irritation leads to symptoms similar to the ones described for dry eye syndrome (DES). In most cases, DES symptoms develop as a consequence of a broad range of different causes and are not only limited to a preceding surgical intervention (cataract, strabismus correction, and laser in situ keratomileusis (LASIK) [48][49][50][51][52]), but DES can also occur in consequence of environmental influences, previous inflammatory diseases (chronic blepharitis, traumatic erosion of the cornea, keratitis of various etiologies, etc.), wearing contact lenses, and taking certain medications (anticholinergic drugs and antihistamines, alpha and beta blockers, antipsychotics, etc. [53]). In all mentioned cases, the initial disturbance of the eye surface is followed by a period of irritation and eye surface discomfort which contributes to a reduced quality of life. ...
... Следует отметить, что частота встречаемости синдрома сухого глаза или роговично-конъюнктивального ксероза, которая, по разным статистическим данным, отмечается у 23-65% населения, обращающегося на прием к офтальмологам, в последние годы увеличилась. Это связано с широким распространением рефракционной эксимер-лазерной хирургии, ношением контактных линз, ухудшением экологических условий, использованием компьютерной техники и кондиционированием воздуха, применением ботокса для инъекций в параорбитальную область [12][13][14]. В связи с тем что средний возраст беременных составляет от 20 до 38 лет, именно эта возрастная группа в наибольшей степени подвержена негативному влиянию вышеуказанных факторов риска развития ССГ. При этом из-за отсутствия научных исследований о влиянии беременности на уровень слезопродукции нет и единого подхода к профилактике и лечению проявлений синдрома сухого глаза, в частности его водоиспаряемой формы, у такой категории пациентов. ...
... Therefore, smart inversion methods have been published. A first original inversion method has been proposed by Duvillaret et al. [94] and is still widely employed. Basically, approximated values n a of n and κ a of κ are easily obtained by omitting the Fabry-Perot term in Eq. (36). ...
... The number of ALDH3A1-stained and CK3-stained cells increased from day 1 to day 7 of culture, indicating that the HKs and HCECs could normally proliferate, synthesize and strongly express proteins within and on the surface of the hybrid constructs, respectively. Additionally, the shape of HKs changed from round to dendritic morphology during the culture within the hybrid construct, which is a typical shape for HKs in vivo [64][65][66] . The change of shape mainly because the cells keep the round shape which is a typical shape after digestion, after culturing for several days, the cells begin to recover their typical spindly shape and proliferate normally. ...
... At the same time, in spite of apparent progress in pharmacology, additional studies of the medication effect on the eye tissue structural elements remain to be an urgent scientific problem, aimed at reducing the possible side effects and increasing the efficiency of the medical treatment procedures. Optical coherence tomography and confocal microscopy are widely used methods of noninvasive control of the cornea thickness and refractive index, of studying its structural features, and of monitoring the diffusion of drugs into a tissue[1][2][3][4][5][6]. Combining several visualisation methods allows wider capabilities of diagnosing the structural and optical cornea parameters[7,8]. ...
... Наиболее часто эти термины используют в клинических ситуациях, когда при наличии подтвержденного КК на парном глазу отсутствуют признаки заболевания на исследуемом [2,3,6,[14][15][16][17][18]. Кроме того, эти понятия могут быть применены в отношении родственников пациентов с верифицированным КК, у которых заболевание менее выражено и проявляется только незначительными кератотопографическими отклонениями [7,[19][20][21], а также в ситуациях, когда КК был диагностирован случайным образом или при скрининговом обследовании, например, у пациентов с астигматизмом или у кандидатов на эксимерлазерную коррекцию зрения [15,[22][23][24]. ...
... Многими авторами понятия «субклиническая (доклиническая, преклиническая) форма», «forme fruste», «латентный КК» и «подозрение на КК» рассматриваются как синонимичные в принципе или по отношению друг к другу [1,2,[6][7][8][9][10][11][12][13]. ...
... Recently, ophthalmic preparations have included D-panthenol in its ingredients, in order to get benefit from its healing effect, at the corneal level [19][20][21]. Yet, few studies have tackled this issue [19][20][21][22][23][24]. ...
... Через небольшой радиальный надрез передней стенки кармана трансплантат вводят в интерламеллярное ложе и размещают в намеченном секторе. В качестве результата авторы описывают остановку прогрессирования КК при длительном сроке наблюдения, повышение КОЗ и НКОЗ [39]. ...
... Egorova et al. [28] concluded that topical use of cyclosporine emulsion 0.05% has a positive effect on morphofunctional parameters of the ocular surface and promotes basal tear secretion and precorneal tear film stability. The prognosis of dry eye in patients treated with cyclosporine 0.05% or artificial tears by using the ITF guidelines was assessed by Rao [29] who concluded that treatment with cyclosporine 0.05% may slow or prevent disease progression in patients with a dry eye at severity levels 2 or 3. Perry et al. [30] in their recently published study found that while topical cyclosporine is beneficial for all levels of dry eye, symptomatic improvement was greatest in patients with mild dry eye. ...