Frederick G Kushner’s research while affiliated with Tulane University and other places

... To minimize DTB time as much as possible, integrated teamwork, realistic goals, and committed compliance are needed [12]. Multiple randomized clinical trials suggested thrombolysis and primary PCI as treatments for STEMI [13,14]. Data from twenty-three randomized trial results show that those who underwent PPCI have less chance of getting nonfatal re-infarction, heart attack, and shortduration mortality than thrombolysis cases in STEMI patients [15]. ...

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A Retrospective Analysis of Door-to-Balloon Time and Its Determinants in STEMI Patients

... Acute coronary syndromes (ACS), the most prevalent cardiovascular disease, is one of the leading causes of high morbidity and mortality worldwide, especially acute myocardial infarction (AMI) (O'Gara et al. 2013), AMI is employed when there is evidence of ischemic damage resulting in necrosis of the cardiac muscle. AMI can be divided into ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) based on whether the ST segment is elevated on the electrocardiogram (ECG), and they share a common pathophysiological basis (O'Gara et al. 2013;Grines and Mehta 2021), both STEMI and NSTEMI require percutaneous coronary intervention (PCI) to open the culprit vessel to restore myocardial blood supply and reduce mortality (Davis and Blankenship 2023). ...

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Reassess Hospital Costs and Mortality Between Myocardial Infarction With and Without ST‐Segment Elevation in a Modern Context

... NSTEMI and UA represent a spectrum of pathologies that involve an imbalance in oxygen supply and demand available to the cardiac muscles [7]. UA and NSTEMI are differentiated by the presence or absence of elevated cardiac troponin (cTn) levels, which signify myocardial damage [8]. Among patients diagnosed with ACS, 70% have NSTEMI diagnosed using cTn assays [9]. ...

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Elevated Troponins and Diagnosis of Non-ST- Elevation Myocardial Infarction in the Emergency Department

... As CVDs are one of the leading causes of disability and mortality in the elderly, it is essential that such conditions must be prevented. Although aspirin was originally commercialized in 1899, it is a vital part of antiplatelet therapy for patients with acute coronary syndromes [6][7][8][9]. However, the role of low-dose aspirin in primary prevention is still debatable [10], with organizations in Europe [11] as well as North America [12] giving conflicting treatment recommendations. ...

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Effect of Low-Dose Aspirin on the Elderly

... Intervention difficulties in a tortuous artery can be overcome by applying a catheter that provides sufficient support; however, such catheters are also associated with a greater risk for iatrogenic vascular complications [4], which, as presented in this case, can be fatal. Nonetheless, urgent revascularization in STEMI is crucial [5], therefore such a risk is acceptable. ...

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Three fatal consequences of one guiding catheter maneuver during primary percutaneous angioplasty in ST elevation myocardial infarction

... The combination of aspirin and thienopyridine derivatives is essential for minimizing the risk of ST, in particular, prolonged DAPT is necessary for patients who are treated with a DES. Although Kotani et al. reported that DAPT performed beyond 12 months was associated with an increased risk of bleeding and that it was not possible to prevent the incidence of major adverse cardiac events (MACE) in patients with sirolimus eluting stents (SES) (20), the Japanese Circulation Society guidelines for the management of patients with ST elevated myocardial infarction (STEMI) recommend at least 1 month of DAPT for BMS patients and 12 months for DES patients (21). However, this recommendation could possibly have been greatly disadvantageous in the case of the AMI patient with concomitant ITP. ...

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Primary Percutaneous Coronary Intervention by a Stentless Technique for Acute Myocardial Infarction with Idiopathic Thrombocytopenic Purpura: A Case Report and Review of the Literature

... The results of this study showed that the D-to-B time of the new mode group, the length of hospital stay and hospital charges were significantly lower than the GC mode group. By using WCACG mode, the STEMI patient's treatment process was simplified and consequently, the average D-to-B time was reduced from 100 min (GC group) to 80 min thereby reaching the 2013 American College of Cardiology Foundation (ACCF) / American Heart Association (AHA) STEMI patient's management requirements [34]. ...

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Applying WCACG modified process is beneficial on reduced door-to-balloon time of acute STEMI patients

... 2. The therapeutic management of acute coronary syndrome includes oxigenotherapy, vasodilators, aspirin, clopidogrel, nitroglycerin, beta-blockers, and calcium channel antagonists [39]. ...

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Kounis Syndrome - a Natural Paradigm

... ST-segment elevation myocardial infarction (STEMI) is a clinical syndrome resulting from myocardial ischemia in association with electrocardiographic (ECG) ST-segment changes (usually elevation) indicative of the occlusion of a major epicardial coronary artery. 1 STEMI remains a significant health problem that contributes to morbidity and mortality worldwide. 2 Mechanical reperfusion by primary percutaneous coronary intervention (primary PCI) is recommended by various guidelines as the preferred reperfusion strategy for STEMI patients who presents to PCI-capable hospitals or non-PCI hospitals with transfer time to PCI within 120 minutes. ...

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Using real world evidence to generate cost- effectiveness analysis of fibrinolytic therapy in patients with ST-segment elevation myocardial infarction in Thailand

... Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, with significant variations in its presentation and outcomes based on demographic factors such as age, sex, and ethnicity (1). Current treatment options for CAD include medical therapy, percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG), tailored according to the severity of the disease and patient-specific factors (2). Despite advancements in diagnostic and therapeutic techniques, disparities in CAD outcomes persist, particularly among different genders (3). ...

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GENDER DIFFERENCES IN CORONARY ARTERY DISEASE PRESENTATION AND OUTCOMES IN PAKISTAN: FOCUS ON LAD, LCX, AND LMS