Francesco Visioli’s research while affiliated with University of Padova and other places

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Publications (278)


Retraction notice to “Fructooligosaccharides: From Breast Milk Components to Potential Supplements. A Systematic Review” [Adv Nutr 13 (2022) 318–327]
  • Article

November 2024

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6 Reads

Advances in Nutrition

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Francesco Visioli

Ultra-processed foods and health: are we correctly interpreting the available evidence?

September 2024

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126 Reads

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1 Citation

European Journal of Clinical Nutrition

Francesco Visioli

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Vincenzo Fogliano

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Several studies have linked adverse health effects to the consumption of ultra-processed foods (UPF) according to the NOVA classification. However, whether the consumption of UPF is the actual causal factor for such health outcomes is still unknown. Indeed, different groups of UPF examined in the same epidemiologic study often show markedly different associations with the occurrence of the health endpoints. In this Comment, we discuss some such studies and point out that the available evidence on how different UPFs have been associated with health, as well as the results of studies examining specific food additives, call into question the possibility that ultra-processing per se is the real culprit. It is possible that other unaccounted for confounding factors play an important role. Future, urgently needed studies will clarify this issue.


Figure 6. Volcanoes of the comparisons of proteins detected between the different groups of patients and between different times (p-value ≤ 0.05; fold change ≥ 1). The points in the center of these volcanoes correspond to those proteins that do not vary in the two situations foreseen in our experimental design. The proteins with statistically significant differences are presented at the right (overexpressed or upregulated) and left (less expressed or downregulated) of the graph.
Outcomes of the bioinformatics analyses performed using the KEGG, STRING, and Top Gene platforms.
Proteins differentially expressed in the comparisons between Placebo.T60 vs. Placebo.T0 and Mygrium ® .T60 vs. Mygrium ® .T0.
Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life
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  • Full-text available

September 2024

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27 Reads

International Journal of Molecular Sciences

Fibromyalgia (FM) is a chronic syndrome of unknown etiology, although many studies point to inflammation, oxidative stress, and altered mitochondrial metabolism as some of the cornerstones of this disease. Despite its socioeconomic importance and due to the difficulties in diagnosis, there are no effective treatments. However, the use of non-drug treatments is increasingly becoming a recommended strategy. In this context, the effects of supplementation of FM patients with an olive (poly)phenol, vitamin C, and vitamin B preparation were investigated in this work, analyzing complete blood count, biochemical, lipid, and coagulation profiles, and inflammation and oxidation status in blood samples. To gain a better understanding of the molecular mechanisms and pathways involved in the etiology of FM, a proteomic study was also performed to investigate the mechanisms of action of the supplement. Our results show that the nutraceutical lowers the lipid profile, namely cholesterol, and improves the oxidative status of patients as well as their quality of life, suggesting that this product could be beneficial in the co-treatment of FM. ClinicalTrials.gov (ID: NCT06348537).

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Natural products: Call for hard evidence

May 2024

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4 Reads

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1 Citation


Natural products: call for hard evidence

May 2024

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1 Read

Given the potential of natural products (NPs) for various aspects of human well-being, it is important to involve a variety of stakeholders and disciplines in the investigation of their health-related properties. For this reason, IUPHAR has initiated a project aimed at establishing a science-based registry of NPs and their pharmacological activities, with a view to providing a better understanding of their potential influences on human health. From a pharmacological perspective, it is important to evaluate the effects of selected NPs on important determinants of health such as, e.g. immune response and inflammation (among others). IUPHAR calls for a concerted effort and asks stakeholders to contribute to this project.




Citations (70)


... Therefore, the food matrix exerts a significant role in promoting the micellarization of specific lipids. This effect presents important implications for the design of functional foods, as incorporating BM-MFGM into food matrices that favor the micellarization of polar lipids could enhance the delivery of these bioactive components to the intestinal epithelium, maximizing their health benefits [27][28][29][30]. As an example of how components of food matrices can enhance the bioavailability of beneficial compounds for the human health, McClements and Xiao [31] described that lipophilic nutraceuticals, such as carotenoids or phytosterols from vegetables sources, present in dressing or sauces are formulated with vegetable oils, which helps to extract the hydrophobic biomolecules from the plant tissue, increasing their absorbance across the gastrointestinal tract. ...

Reference:

The Role of Food Matrices Supplemented with Milk Fat Globule Membrane in the Bioaccessibility of Lipid Components and Adaptation of Cellular Lipid Metabolism of Caco-2 Cells
Milk fat globule membrane and its polar lipids: reviewing preclinical and clinical trials on cognition

Food & Function

... The preparation and sharing of food within a family setting enhances the efficiency of food management, as family members are more likely to share meals and collaborate in meal planning and preparation. This collective approach not only reduces food waste but also promotes healthier eating habits and strengthens family bonds [29]. ...

Fostering wellbeing and healthy lifestyles through conviviality and commensality: Underappreciated benefits of the Mediterranean Diet
  • Citing Article
  • March 2024

Nutrition Research

... On the basis of the "oxidative stress theory", in the last years researchers started to focus their attention on natural antioxidants as a means to slow down the aging process and prevent the main age-related diseases. Natural antioxidants, such as vitamins and polyphenols, are indeed natural substances present in plant-based foods that exert several beneficial effects on human health, contributing to maintain a good well-being and preventing many human chronic diseases, thanks to their ability in scavenging free radicals and decreasing oxidative stress [15][16][17][18][19][20][21][22][23][24][25]. ...

Differences in carotid to femoral pulse wave velocity and carotid intima media thickness between vegetarian and omnivorous diets in healthy subjects: a systematic review and meta-analysis
  • Citing Article
  • January 2024

Food & Function

... Buttermilk (BM), a traditional food-grade by-product from the dairy industry, has been employed as a source of MFGM due to its high concentration of polar lipids [14][15][16]. A concentrate of MFGM from BM (BM-MFGM) was prepared to study the possibilities of its use as a future food supplement to slow progression of age-related cognitive decline [17], although the use of in vitro models comes first to study the molecular mechanisms and their effect on the intestinal cell lipid metabolism after an in vitro digestion protocol. ...

Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
  • Citing Article
  • December 2023

Journal of Functional Foods

... Epidemiological studies have investigated the beneficial health effects of olive biophenols and their pharma-nutritional properties [30,57]. Some studies report that these compounds have cardioprotective activities [31] and also improve the lipidic profile [58,59], but there is no consensus on this issue [31,60,61]. Our data show that the administration of an olive (poly)phenol to patients suffering from FM augments their lipid profiles, thereby decreasing their cardiovascular disease risk and adding to the debate. ...

The Question of Cholesterol: Will Olive Oil Answer?
  • Citing Article
  • November 2023

Journal of Nutrition

... These five differentially expressed proteins might be related to exosomes, extracellular vesicles secreted by different cells that transport various substances [91]. Of note, these particles have been linked to different pain-related pathologies [92]. ...

Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous miRNAs
  • Citing Article
  • November 2023

Pharmacological Research

... Similar antioxidant effects are observed with tocopherols (vitamin E) and ascorbic acid (vitamin C), both of which contribute to the overall protective properties of olive oil. However, recent findings from animal model studies have reported that hydroxytyrosol supplementation was associated with increased weight gain, warranting further investigation into the metabolic effects of this polyphenol [48]. High consumption of fruits and vegetables contribute to significant amount of minerals that play an crucial role of cofactor for superoxide dismutase and glutathione peroxidase, antioxidant systems that maintain balanced redox status [49]. ...

Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model
  • Citing Article
  • November 2023

Molecular Nutrition & Food Research

... Furthermore, pretreatment of neutrophils with BARI-L-EVs and ITA-L-EVs resulted in reduced ROS production, consistent with increased oleate, linoleate (C18:2), and linolenate (C18:3) content within the vesicles. These findings support previous research on the antioxidant properties of polyunsaturated FAs [72][73][74][75][76]. For instance, Richard et al. demonstrated that different FAs could modulate ROS production by human aortic epithelial cells. ...

Quenching of Intracellular ROS Generation as a Mechanism for Oleate-Induced Reduction of Endothelial Activation and Early Atherogenesis
  • Citing Article
  • September 2023

... Because of the inconsistency in predictors of suicidal ideation among college students, few systematic investigations have been conducted on the impact of mental illness on suicidal behavior among college students. Literature [22] investigated the main problems of mental health among college students, indicating that the psychological condition of young people in academia is much worse than that of other people of the same age. The study concluded that the mental health problems of college students have become serious enough to be a cause for concern. ...

Frequency and machine learning predictors of severe depressive symptoms and suicidal ideation among university students

Epidemiology and Psychiatric Sciences

... Previous research has shown a potential positive correlation between SFA and hs-CRP [65]. Ultimately, another potential mechanism that may contribute to the positive effects of a plantbased diet is related to reducing complications of cirrhosis, such as hepatic encephalopathy [66], hypertension [67], and glucose intolerance [68,69], all of which are related to the worsening prognosis for survival [70][71][72]. ...

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Current Hypertension Reports