Francesca Cammarota's research while affiliated with University of Naples Federico II and other places

Publications (9)

Article
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Among matrix metalloproteinases (MMPs), MMP-9/2 are key enzymes involved in the proteolysis of extracellular matrices in the inflammatory process and in cancer. Since MMP-9/2 expression levels, activity, and secretion is up-regulated during inflammation in response to pro-inflammatory cytokines, such as interleukin-6 (IL-6), many efforts have been...
Article
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Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that phosphorylates various transcriptional and chromatin regulators, thus modulating numerous important cellular processes, such as proliferation, apoptosis, DNA damage response, and oxidative stress. The role of HIPK2 in the pathogenesis of cancer and fibrosis is well e...
Article
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Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by germline mutations in specific genes. Several factors, such as growth factors, cytokines, and genetic o...
Article
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Peutz–Jeghers Syndrome (PJS) is an autosomal dominant pre-cancerous disorder caused in 80–90% of cases by germline mutations in the tumor suppressor gene STK11. We performed a genetic test of the STK11 gene in two Italian young sisters suspected of PJS, since they showed pathognomonic café au lait spots in absence of other symptoms and familiarity....
Article
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Balneotherapy and spa therapy have been used in the treatment of ailments since time immemorial. Moreover, there is evidence to suggest that the beneficial effects of thermal water continue for months following the completion of treatment. The mechanisms through which thermal water exerts its healing effects remain unknown. Both balneological and h...
Article
Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary precancerous condition caused by germline pathogenetic variants in the tumor suppressor adenomatous polyposis coli (APC) gene. Patients with FAP develop multiple gastrointestinal adenomatous polyps usually at the age of ~20 years, which, if untreated, become cancerous in 100%...
Article
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Colorectal cancer (CRC) is the third most prevalent type of cancer worldwide. It is also the second most common cause of cancer‑associated mortality; it accounted for about 9.2% of all cancer deaths in 2018, most of which were due to resistance to therapy. The main treatment for CRC is surgery, generally associated with chemotherapy, radiation ther...
Article
Full-text available
Colorectal cancer (CRC) has been ranked as the third most prevalent cancer worldwide. Indeed, it represents 10.2% of all cancer cases. It is also the second most common cause of cancer mortality, and accounted for about 9.2% of all cancer deaths in 2018. Early detection together with a correct diagnosis and staging remains the most effective clinic...
Article
Full-text available
The serine–threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) modulates important cellular functions during development, acting as a signal integrator of a wide variety of stress signals, and as a regulator of transcription factors and cofactors. We have previously demonstrated that HIPK2 binds and phosphorylates High-Mobility Group...

Citations

... Our results corroborate studies that show an increase in gelatinolytic activity in the aortas of atherosclerotic animals and humans [42,43,[45][46][47]. Classically, the activity of MMPs can also be evaluated by the gel zymography technique described in 1980 [48], which is still widely used [49][50][51][52][53][54][55]. The increase in MMP-2 activity by gel zymography is shown in different models of atherosclerosis, which demonstrates that the rise in the activity of this gelatinase results in the progression of atherosclerotic lesions [23,55,56]. ...
... Homeodomain-Interacting Protein Kinase 2 (HIPK2) is a protein kinase involved in important cellular processes including cell proliferation, apoptosis, and mitochondrial function. 7 Recently, its roles in cardiovascular function have been explored in various models including HIPK2 loss-of-function and transaortic constriction-induced heart failure mouse models. 7,8 In this issue of EBiomedicine, Zhou and colleagues 9 further demonstrate the important association between HIPK2 and exercise, and the underlying mechanisms responsible for cardioprotection. ...
... Another drug that inhibits the activity of the Met receptor by inducing the degradation of β-catenin is celecoxib [116]. However, recent evidence indicates that the combined treatment of celecoxib with the usual chemotherapy did not improve overall survival or progression-free time in patients with CRC [131]. ...
... Cerasuolo and co-workers used a combined molecular and bioinformatics approach to investigate the molecular basis of the genotype-phenotype correlation of Peutz-Jeghers syndrome, a disorder characterized by the development of noncancerous hamartomatous polyps in the gastrointestinal tract [13]. In the majority of cases, the disorder is caused by mutations in the tumour suppressor gene STK11. ...
... To set up the optimal conditions and discriminate apoptotic cells from live cells, we used RKO and HEK 293T untreated cells as internal controls in these experiments. When these cells were induced to undergo apoptosis by a 24 h treatment with 60 mM LiCl, a GSK3β inhibitor known to induce apoptosis in several human cell lines [35][36][37], they exhibited a high percentage of subdiploid cells ( Figure 3A). In contrast, when Dox-treated RKO and HEK 293T cells were analyzed for their DNA content, they presented only a negligible percentage of the subdiploid peak ( Figure 3A), indicating that they are not subjected to apoptosis. ...
... CRC tumors are highly heterogeneous in their intratumor and intertumor characteristics because of microsatellite instability (MSI), chromosomal instability (CIN), DNA repair defects, aberrant DNA methylation, and other factors. These factors determine how colorectal cancer patients (CRCpts) respond to specific therapy (2). In the era of precision oncology, implicit molecular characterization of the tumor is essential in defining the best therapeutic plan. ...
... On the other hand, HIPK2 expression strongly increases after skeletal muscle contusion in neutrophils, macrophages, and myofibroblasts [24]. Finally, we recently reported that the double KO of HIPK2 and high-mobility group A1 (HMGA1), a chromatin non-histone protein previously identified as HIPK2 interactor and substrate, causes perinatal death due to respiratory failure, associated with impaired lung development and reduction in surfactant proteins, as well as reduced expression of thyroid differentiation markers [25]. ...