Fleur Lerebours's research while affiliated with University of Toulouse and other places

Publications (12)

Article
Full-text available
Introduction Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functions...
Preprint
Full-text available
Introduction : Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functio...
Article
Full-text available
Background It is currently unknown whether early B cell reconstitution (EBR) in MS patients under rituximab is associated with a risk of relapse or progression. Objectives Analyzing EBR in rituximab-treated patients and its putative association with clinical findings. Methods Prospective lymphocytes immunophenotyping was performed in a monocentri...
Article
Full-text available
Introduction: Migraine with aura (MWA) has been associated with cryptogenic ischemic stroke (CIS) after adjustment for the presence of a patent foramen ovale (PFO) assessed by a transcranial Doppler. This study aimed at evaluating the association of MWA with causal PFO assessed by Transesophageal echocardiography (TEE) in CIS. Methods: Patients ag...
Article
Introduction: Migraine is a risk factor for ischemic stroke, but the mechanisms of stroke associated with migraine are debated. The aim of this study was to investigate the association between migraine and large artery atherosclerosis (LAA) in young adults with ischemic stroke. Methods: Patients aged between 18 and 54 years consecutively treated...
Article
Background Leptomeningeal enhancement (LME) is a key feature of Susac syndrome (SuS) but is only occasionally depicted on post-contrast T1-weighted images (T1-WI). Objective As post-contrast fluid-attenuated inversion recovery (FLAIR) may be more sensitive, our aim was to assess LME in SuS on this sequence. Methods From 2010 to 2020, 20 patients...
Article
Full-text available
Background Multiple sclerosis (MS) patients represent a population potentially affected by the intracerebral accumulation of gadolinium-based contrast agents (GBCA) due to repeated magnetic resonance imaging (MRI) performed during their lifetime; however, MRI is still the best tool to monitor MS inflammatory activity. Objective This study aimed to...
Article
Full-text available
A patient with severe idiopathic lymphopenia and progressive multifocal leukoencephalopathy had T-cell exhaustion and high expression of immune checkpoint markers. Treatment with the PD-1 blocker nivolumab led to a reduced CSF JC viral load, stable clinical features, and an immune reconstitution inflammatory response on MRI.
Article
Objective: To investigate the functional connectivity of the hypothalamus in chronic migraine compared to interictal episodic migraine in order to improve our understanding of migraine chronification. Methods: Using task-free fMRI and ROI-to-ROI analysis, we compared anterior hypothalamus intrinsic connectivity with the spinal trigeminal nucleus...
Article
Late-onset neutropenia after rituximab therapy (LONART) is defined as a fall in the absolute neutrophil count below 500/mm³ at least 3 weeks after rituximab infusion, in the absence of any other explanation. LONART is rare during dysimmune conditions but can be life-threatening. We report on two patients with LONART and associated neurological rela...
Article
Objectif Évaluer l’intérêt de l’injection de gadolinium dans le suivi IRM des patients SEP sous Tysabri. Matériel et méthode Étude rétrospective monocentrique des IRM cérébrales de suivi des patients consécutifs traités par Tysabri entre janvier 2014 et janvier 2017. Les prises de contraste en T1 après Gadolinium et les nouveaux hypersignaux T2/FL...

Citations

... Totally, 16 FC studies were included in this study. Among them, the seed-points were distributed the middle frontal gyrus (31), precuneus (32), PAG (33,36,44), insulas (35,37,45), thalamus (38,43,46), pons (26,39), lateral geniculate nucleus (40), amygdala (41), and lingual gyrus (42). ...
... The wide range of imaging techniques currently available, such as brain MRI, fluorescein angiography (FA), optical coherence tomography (OCT), and OCT angiography (OCTA), allow the recognition of anatomical and physiological correlations underlying the pathology of SS [2,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. MRI and FA both enable the imaging of pathognomonic changes for SS [2]. ...
... In conclusion, MK offered good discriminative value between different MS lesion types. Most importantly, MK differed significantly between enhancing and non-enhancing MS lesions, supporting its usefulness as a potentially image marker to assess lesion acuity without the use of gadolinium, which is in general a point of critical debate [56,57]. With the fast acquired and easy to post-process DKI sequence used in this study, it can be easily implemented into research protocols and most importantly, clinical routine. ...
... Frontiers in Systems Biology | www.frontiersin.org been applied in several PML patients with some, albeit not all, patients showing promising responses leading to JC virus clearence (Tan et al., 2012;Berger, 2019;Cortese et al., 2019;Rauer et al., 2019;Walter et al., 2019). Whether elevated PD-1 in STAT1 GOF will be more widely described and building on this whether PD-1 blockade might provide an adjunctive therapy for STAT1 GOF patients will remain to be seen in the future but provides an interesting example of an alternative therapeutic option. ...
... Previous functional MRI (fMRI) studies on amplitude of low-frequency fluctuations, regional homogeneity, and functional connectivity density (FCD) have discovered abnormalities in the CN of migraine and MOH populations compared with those in the control population [20][21][22]. Enhanced FC between the hypothalamus and the CN has also been reported in individuals with CM [23]. One study compared the bilateral temporal pole, ipsilateral insula, ipsilateral middle frontal gyrus, and contralateral parahippocampus of migraine patients and reported a significantly lower FC of the CN in patients whose migraine episodes progressed than in patients whose migraine episodes did not progress [24]. ...
... From 2016 to 2020, 16 articles documented the treatment response to rituximab in patients with MOG-AD. One was a prospective study [18], seven were retrospective studies [5, 9-11, 17, 27, 35], and eight were case series [14,15,21,24,28,31,32,34] that included 253 patients, overall. The treatment regimens of rituximab varied widely across these articles. ...