Flavio Tangianu's research while affiliated with Ospedale di Circolo e Fondazione Macchi Varese and other places

Publications (20)

Article
Some patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience acute hypoxemic respiratory failure progressing toward atypical acute respiratory distress syndrome (ARDS). The aim of the study is to evaluate whether a correlation between ratio of peripheral saturation of oxygen (SpO2) and fraction of inspired oxyge...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is capable of inducing the activation of NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome, a macromolecular structure sensing the danger and amplifying the inflammatory response. The main product processed by NLRP3 inflammasome is interleukin (IL)-1β,...
Article
Full-text available
Background Venous thromboembolism is a frequent complication of COVID-19 infection. Less than 50% of pulmonary embolism (PE) is associated with the evidence of deep venous thrombosis (DVT) of the lower extremities. DVT may also occur in the venous system of the upper limbs especially if provoking conditions are present such as continuous positive a...
Article
Background: In COVID-19 patients the progressive clinical deterioration seems secondary to the activation of a cytokine storm. Ferritin is considered a direct mediator of the immune system and some evidences suggested a shared physio-pathogenic basis between COVID-19 and "Hyperferritinemic Syndromes". The aim of our study was to evaluate the progn...
Chapter
COVID-19 represents a major challenge for researchers worldwide. Although the fine mechanisms that lead to the cell and tissue damage in patient infected by SARS-CoV-2 and that develop the disease are still unknown, the global effort to find a cure brought scientists worldwide to produce a considerable number of publications that are slowly disclos...
Article
Full-text available
Low-dose dexamethasone reduces mortality in patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). We retrospectively analyzed the efficacy of high-dose dexamethasone in patients with COVID-19-related ARDS and evaluated factors affecting the composite outcome (death or invasive mechanical ventilation)....
Book
This book assesses the main features of COVID-19 from a clinical point of view, based on observations made during the disease epidemic in Northern Italy, one of the most affected areas in the world (the region has been the epicenter of the global pandemic for more than a month), and the first region outside China facing overwhelming numbers of case...
Article
As the main title ‘COVID-19 revolution: a new challenge for the internist’ states, the global coronavirus infection disease 2019 (COVID-19) pandemic represented a new challenge for the internists. This paper is part of a series of articles written during the difficult period of the ongoing global pandemic and published all together in this fourth i...
Article
Full-text available
Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for e...
Preprint
Full-text available
As the tide of Covid-19 flood the world, health authorities are implementing a number of measures that have deeply changed the way people live. However, there is no shared consensus on how to communicate to the public what is happening, and why these extreme interventions are needed. Instead, people received in the latest weeks contrasting messages...
Article
Full-text available
In year 2000 the Nobel Laureate Joshua Lederberg wrote in a famous statement: “It’s our wits versus their genes” [1]. The imbalance of powers in the fight against microbes is coming to light, as the Covid-19 infection is striking the world. Not by chance, Lederberg’s lament concluded a recent paper with the evocative title of “Escaping Pandora’s bo...
Article
Lo studio dei pattern di co-morbilità può essere utile per migliorare la gestione clinica di ciascun sottogruppo specifico di pazienti con una de-terminata patologia indice, per il miglior risultato di cura. La valutazione dei pazienti complessi non può basarsi solamente su pochi elementi di giudizio. Essa dovrebbe richiedere una valutazione multi-...
Article
Direct oral anticoagulants (DOACs) include dabigatran, which inhibits thrombin, and apixaban, edoxaban, and rivaroxaban, which inhibit factor Xa. They have been extensively studied in large trials involving patients affected by the most common cardiovascular diseases. As the presence of diabetes leads to peculiar changes in primary and secondary he...
Article
Full-text available
Internal medicine patients are mostly elderly with multiple comorbidities, usually chronic. The high prevalence of comorbidity and multimorbidity has a significant impact on both positive responses to treatment and the occurrence of adverse events. Clustering is the process of nosography grouping into meaningful associations with some index disease...
Article
Full-text available
There are many feasible tools for the assessment of clinical practice, but there is a wide consensus on the fact that the simultaneous use of several different methods could be strategic for a comprehensive overall judgment of clinical competence. Multiple-choice questions (MCQs) are a well-established reliable method of assessing knowledge. Constr...
Article
Full-text available
The aim of this study was to evaluate the management practices of internal medicine clinicians for patients with cardiovascular risk factors, with particular respect to treatment thresholds, medication choices and target goals. A sample of internists - representatives of Internal Medicine Units (IMUs) from all the regions in Italy - were identified...

Citations

... Recent study suggests that activation of the pyrin domain-containing protein 3 (NLRP3) inflammasome is associated with SARS-CoV-2 infection [3], with subsequent activation of interleukin (IL)-1, responsible for the downstream production of IL-6 [4]. Colchicine is known to block (NLRP3) inflammasome [5]. ...
... unvaccinated patients. In previous studies, an increase in CRP, ferritin, and D-dimer was reported in COVID-19 patients.[28][29][30] Although prognostic factors, such as CRP, D-dimer, and ferritin were found to be higher in unvaccinated and partially vaccinated patients compared to fully vaccinated patients, the differences were not statistically significant (p > 0.05). ...
... 11 Numerous studies have investigated differing methodologies for the administration of dexamethasone with the aim of enhancing its efficacy in COVID-19 hospitalised patients. [12][13][14][15][16][17] One study found that oral or intravenous (IV) high-dose dexamethasone, 10mg 1x/day for six days or 20mg 1x/day for five days, followed by 10mg 1x/day for five days, at a cumulative dose of either 60 or 150mg, decreased the mortality rate for COVID-19 patients requiring respiratory support (mechanical ventilation or supplemental oxygen). 12 The patients in this study who required respiratory support (n=1,192) were over the age of 51 (79.1%), non-obese (71%), non-smokers (84.8%), and had an underlying medical condition (66.5%). ...
... This may have been caused by a lack of seroconversion in some patients, as plasma was collected within the first week after hospital admission. According to the literature, at least 11-14 days after the onset of the disease is reported to be necessary to observe an average seroconversion rate of approximately 90%-100% for antibodies (IgM or IgG) against the SARS-CoV-2 S and N proteins (31,(60)(61)(62)(63)(64)(65)(66)(67)(68)(69). Future investigations of the antibody dynamics, including in the early (acute) and late (convalescent) phases of COVID-19 infection, may provide more insight into this issue. ...
... Cycle threshold (Ct) values range in saliva around 24-40 (Azzi et al., 2020a(Azzi et al., , 2020bBarra et al., 2021), with 28.5-35 for the ORF1ab gene and 28.4-33.7 for the N gene as observed by Pasomub and colleagues (Pasomsub et al., 2021). Early morning samples had the highest viral load in hospitalized patients . ...
... In conclusion, as pasta is one of most common food in all the world, we focus on it for its clinical relevance in determining GI but also for the close relationship between food, immune response and individual antiviral defence [41] which needs to be better investigate. Probably the characteristics of the final mixture (starch and protein component) and in particular its rheological characteristics (viscosity, elasticity, toughness, etc.) can influence GI. ...
... The analysis of multimorbidity patterns may be an appropriate tool to model the complexity of patients in terms of the diversity in and statistical co-occurrences of various health conditions [21][22][23][24][25]. This type of modeling is usually applied to populations of complex and chronic patients with high multimorbidity however many opportunities to extend this analysis to broader factors like disease pathways in patients are still possible [26,27]. ...
... Su uso facilita la evaluación de gran cantidad de estudiantes en poco tiempo, brindando estandarización, objetividad y efectividad 5,9,10 . Las POM de calidad se basan en viñetas con situaciones clínicas realistas, que contribuyen a evaluar la aplicación del conocimiento y el uso de procesos cognitivos superiores, en lugar de la simple memorización de hechos 23 . Sin embargo, su uso sin aseguramiento de criterios de calidad puede generar consecuencias no deseadas en términos de las inferencias de validez de las evaluaciones y el aseguramiento de la adquisición de competencias de los estudiantes. ...