Fiqi Diyona’s scientific contributions

Telah dilakukan optimalisasi priority pada Organ At Risk (OAR) kanker nasofaring menggunakan teknik Intensity Modulated Radiation Therapy (IMRT). Penelitian dilakukan mengggunakan 5 citra pasien kanker nasofaring yang diolah menggunakan software Treatment Planning System (TPS) Eclipse di Rumah Sakit Universitas Andalas. Tujuan penelitian ini adalah untuk mengetahui nilai priority pada Planning Target Volume (PTV) dan OAR dengan menganalisis nilai Conformity Index (CI), Homogeneity Index (HI) dan dosis radiasi OAR pada kurva Dose Volume Histigram (DVH) berdasarkan 6 variasi perencanaan. Variasi perencanaan yang digunakan yaitu nilai priority pada PTV 100,110,120,130,140 dan 150. Variasi nilai priority pada OAR 40,50,60,70,80 dan 90. Hasil penelitian diapatkan nilai priority optimal masing-masing inisial pasien kanker nasofaring adalah S, J, SS, ED dan B untuk PTV yaitu 120. Pada OAR batang otak adalah 103,85,90,103, dan 85. OAR sumsum tulang belakang 82,88,85,85, dan 85. OAR lensa mata adalah 58,100,90,85 dan 90. OAR mata adalah 65,90,70,0 dan 80. OAR mandibula adalah 72,100,90,99 dan 80. Analisis nilai CI dan HI berdasarkan International Commission on Radiation Units and Measures (ICRU) Report 62 dan 83. Dosis radiasi pada OAR diverifikasi berdasarkan standar Quantitative Analysis of Normal Tissue Effect in the Clinic (QUANTEC). Nilai priority yang didapatkan pada penelitian ini akan menjadi acuan fisikawan medis dalam membuat perencanaan radioterapi.

The negative effects of increased radiation dose can impact healthy tissue surrounding the target area, necessitating careful management to minimize side effects and meticulous planning in radiation therapy. This study aims to determine the peripheral dose of a 6 MV photon beam and compare the measured values with the estimates from the Treatment Planning System (TPS). Dose calculations were performed using the Analytical Anisotropic Algorithm (AAA) in the ECLIPSETM TPS on a virtual water phantom with a 6 MV photon beam, delivered by a Clinac CX linear accelerator (LINAC) at Unand Hospital. Photons were used with variations in target depth of 1.5, 5, and 10 cm, as well as variations in measuring distances of 3, 5, 7, 10, and 15 cm outside the irradiation field. The area of irradiation used varied of 5×5 and 10×10 cm2. The measurement results based on the distance of the field edge showed that the dose percentage decreased below 10% when passing a distance of 5 cm for a field area of 5×5 cm2, and for a field area of 10×10 cm2, the dose percentage decreased below 10% after passing a distance of 7 cm from the edge of the irradiation field. The peripheral dose intensity in the area outside the target will decrease along with the increasing measurement distance from the edge of the field and the depth due to the interaction of radiation with the medium, which causes the spread and absorption of photons in the medium.

A dosimetric analysis of a 6 MV photon energy radiation beam on flatness and symmetry in LINAC radiotherapy at UNAND Hospital has been conducted. The aim was to measure the quality of the photon beam using an ion chamber cc 13 detector by observing the beam profile and analyzing the effect of field size and irradiation depth. This study used a blue phantom as the object of irradiation with 6 MV photon energy and variations in irradiation field size. The results showed that the PDD curve at 6 MV energy was by the international standard recommended by BJR-25. Then, the average values of flatness and symmetry in the field area of 10×10 cm2 and 15×15 cm2 are 1.6% and 2.4% for flatness and 2.3% and 1.9% for symmetry. Thus, the dose distribution is more uniform, and both the left and right sides of the profile on the center axis appear balanced, which will help deliver the dose to the patient better. Thus, these values are suitable for clinical use. This study found that the beam profile was larger on the left side of the main axis. This must be considered to ensure the dose distribution complies with the established safety standards. The results also show that variations in the field area and irradiation depth can affect the beam profile, and the resulting flatness and symmetry values are in accordance with the IAEA TRUS-381 and AAPM TG-142 recommendation standards, which are ±2% flatness and ±3% symmetry.

Telah dilakukan verifikasi dosis permukaan metode dosimetri in vivo pada kasus kanker payudara menggunakan TLD-100 di instalasi Onkologi Radiasi Rumah Sakit Universitas Andalas. Penelitian ini bertujuan untuk mengukur dosis permukaan pasien kanker payudara menggunakan TLD-100 pada fantom homogen (slab phantom). Penelitian diawali dengan annealing TLD-100 di Pusat Riset Teknologi Keselamatan Metrologi dan Mutu Nuklir Badan Riset Inovasi Nasional (PRTKMMR-BRIN). Penelitian diawali dengan scan TLD-100 pada permukaan slab fantom menggunakan CT-Simulator, selanjutnya pengukuran dosis radiasi permukaan dengan variasi dosis radiasi. Perhitungan dosis radiasi permukaan pada TPS dilakukan melalui verifikasi Patient Spesific Quality Assurance (PSQA) dengan konversi dosis teknik 3D-CRT pasien kanker payudara menggunakan slab phantom. Verifikasi dosis radiasi permukaan dilakukan dengan menghitung diskrepansi dosis radiasi yang dihitung oleh TPS dengan dosis yang diukur oleh TLD-100. Hasil pengukuran dosis radiasi permukaan yang diterima oleh pasien kanker payudara minimal pada dosis 115,07 cGy hingga 130,81 cGy. Diskrepansi dosis radiasi berkisar antara 0,21% sampai 8,13% dengan demikian dosis radiasi yang diterima oleh pasien berada dalam batas toleransi yang ditetapkan oleh AAPM TG No. 219 sebesar 20%.

Kanker payudara menempati urutan pertama di Indonesia dan menjadi salah satu penyumbang kematian utama akibat kanker. Penanganan Kanker payudara dapat dilakukan menggunakan terapi radiasi atau biasa disebut radioterapi. Salah satu modalitas yang sering digunakan dalam radioterapi adalah Linear Accelerator (Linac). Agar terapi radiasi dapat mengenai target kanker dan aman Organ-At-Risk (OAR) perlu dilakukan evaluasi perencanaan terapi radiasi. Evaluasi dilakukan terhadap dua teknik perencanaan terapi radiasi yaitu teknik Three Dimensional Conformal Radiotherapy (3D-CRT) dan Intensity Modulated Radiation Therapy (IMRT). Uji terapi radiasi dilakukan terhadap 3 orang pasien kanker payudara kiri. Hasil analisis dosis pada OAR menggunakan teknik 3D-CRT diperoleh sebaran dosis target dan perlindungan terhadap OAR lebih baik dibandingkan dengan teknik perencanaan 2D. Perencanaan terapi radiasi terbaik diperoleh pada teknik IMRT. Pada teknik perencanaan tersebut diperoleh sebaran dosis lebih homogen pada target maupun capaian dosis pada OAR sekitar target kanker.

Telah dilakukan perbandingan dosimetri perencanaan Intensity Modulated Radiotherapy (IMRT) menggunakan fasilitas beam angle optimization dan teknik manual pada kasus kanker nasofaring (KNF) stadium III. Penelitian bertujuan untuk menganalisis nilai Conformity Index (CI), Homogeneity Index (HI), dan dosis pada Organ at Risk (OAR) pada kurva Dose Volume Histogram (DVH), serta jumlah Monitor Unit (MU). Terdapat empat variasi perencanaan yang diuji, yaitu IMRT 5 lapangan manual (M5), IMRT 5 lapangan dengan beam angle optimization (O5), IMRT 7 lapangan manual (M7), dan IMRT 7 lapangan dengan beam angle optimization (O7). Secara statistik, hasil penelitian menunjukkan semua perencanaan pada PTV54, PTV60, dan PTV70 memiliki hasil yang hampir identik pada keempat variasi perencanaan tersebut. Namun, perencanaan O5 didapatkan lebih unggul karena memiliki rata-rata nilai CI dan HI yang paling sesuai dengan pedoman International Commision on Radiation Units and Measurements (ICRU) Report 62, yaitu CI pada PTV54 (0,969±0,03), CI pada PTV60 (0,949±0,04), dan CI pada PTV70 (0,954±0,04), serta HI pada PTV54 (0,223±0,13), HI pada PTV60 (0,250±0,10), dan HI pada PTV70 (0,126±0,07). Perencanaan O5 juga memenuhi batas yang ditetapkan oleh Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) untuk OAR. Oleh karena itu, perencanaan O5 dianggap sebagai metode utama yang paling optimal untuk kasus KNF stadium III, sementara M5 dapat dijadikan sebagai alternatif karena menggunakan Monitor Unit (MU) yang lebih sedikit

Radiotherapy is a non-surgery therapy that employs ionizing radiation like X-ray or even radiation to cure cancer as a curative activity. Radiation dose rate analysis is required for the person who worked on radiotherapy to strengthen safety precautions for radiation protection, notably in oncology radiation. The research attempted to disclose time trends and radiation dose rate exposure variations among personnel in radiotherapy installation. Radiation dose examination utilizing four-elements TLD received from 16 respondents grouped into six groups (radiation oncologist, medical physicist, radiotherapist, electromedicine, nurse, and sculptor). The number of occupancy exposures rose 55.5% from 2018 to 2022. The most significant annual radiation dose rate for 900 patient workloads attained by medical physicists was 0.996 mSv. In addition, electronics receive the lowest annual radiation dose at Unand Hospital. Annual effective dose exposure by radiation is still safe, below national or international regulations. However, a protective improvement process is vital to limit radiation interaction, particularly for medical physicists, who are the most vulnerable to radiation exposure.

The Radiotherapy Unit at Andalas University Hospital (Unand Hospital), Padang City, has a brachytherapy facility with multichannel indexer technology of High Dose Rate on the Remote after Loading System type MicroSelectron HDR and has 6 channels. The radioactive source used is Iridium-192 or Ir-192, with an initial activity of about 12 Ci. This study uses a well-type chamber ionization detector to verify the brachytherapy source against HDR Ir-192. The well-type chamber detector measures the radiation dose given to the patient during the brachytherapy procedure. This study uses detectors to measure radiation dose at several points around the source. The study was conducted by verifying the activity of the radiation source in Ir-192 brachytherapy using a voltage of 200 V and 400 V. It was regulated using an electrometer connected to a detector. The results show that the well-type chamber detector could accurately verify the source of brachytherapy. In addition, the measured activity values are in accordance with those permitted in standardization in brachytherapy, which is around 10 to 12 GBq. Therefore, well-type chamber ionization detectors can effectively verify brachytherapy sources. Thus, proper radiation source verification is paramount to ensure patient safety and treatment effectiveness