Fernando Fernández-Aranda’s research while affiliated with University of Barcelona and other places

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Publications (596)


The current clinical approach to feeding and eating disorders aimed to increase personalization of management
  • Article

January 2025

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71 Reads

World psychiatry: official journal of the World Psychiatric Association (WPA)

Ulrike H. Schmidt

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Fernando Fernández‐Aranda

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[...]

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Feeding and eating disorders (FEDs) are a heterogeneous grouping of disorders at the mind‐body interface, with typical onset from childhood into emerging adulthood. They occur along a spectrum of disordered eating and compensatory weight management behaviors, and from low to high body weight. Psychiatric comorbidities are the norm. In contrast to other major psychiatric disorders, first‐line treatments for FEDs are mainly psychological and/or nutrition‐focused, with medications playing a minor adjunctive role. Patients, carers and clinicians all have identified personalization of treatment as a priority. Yet, for all FEDs, the evidence base supporting this personalization is limited. Importantly, disordered eating and related behaviors can have serious physical consequences and may put the patient's life at risk. In these cases, immediate safety and risk management considerations may at least for a period need to be prioritized over other efforts at personalization of care. This paper systematically reviews several key domains that may be relevant to the characterization of the individual patient with a FED aimed at personalization of management. These domains include symptom profile, clinical subtypes, severity, clinical staging, physical complications and consequences, antecedent and concomitant psychiatric conditions, social functioning and quality of life, neurocognition, social cognition and emotion, dysfunctional cognitive schemata, personality traits, family history, early environmental exposures, recent environmental exposures, stigma, and protective factors. Where possible, validated assessment measures for use in clinical practice are identified. The limitations of the current evidence are pointed out, and possible directions for future research are highlighted. These also include novel and emerging approaches aimed at providing more fine‐grained and sophisticated ways to personalize treatment of FEDs, such as those that utilize neurobiological markers. We additionally outline remote measurement technologies designed to delineate patients’ illness and recovery trajectories and facilitate development of novel intervention approaches.


Fig. 3. Cumulative survival functions for the rate of relapses and dropout
Logistic regression with the final discriminative modelsFig. 2. Treatment outcomes: risk of dropout and relapses during therapy
Poisson regression with the final discriminative models
Features related to the presence of internet gaming disorder and their impact on the treatment outcomes
  • Article
  • Full-text available

January 2025

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9 Reads

Journal of Behavioral Addictions

Background and aims Internet gaming disorder (IGD) is a highly engrossing activity with the individual spending up to 10 h per day gaming, this causes issues in accomplishing their tasks and personal goals. Also, to generate in them increased anxiety, impulsivity and lack of social skills, this impacts the good personal development and individual's quality of life. Therefore, it is vital to better understand, in terms of treatment, which factors are associated with therapeutic outcomes (largely to achieve control over the use of video games and the lack of relapses) following a standardized Cognitive Behavioral Therapy (CBT) protocol. This study aimed to explore sociodemographic and personality variables and their relation to treatment outcome in patients with IGD. Method The sample included n = 105 patients with IGD, considered between January 2005 and December 2022 and recruited from the Behavioral Addictions Unit at the University Hospital of Bellvitge. Data at baseline was registered (sociodemographic and clinical measures), as well as the therapy outcomes (compliance with the guidelines, presence of relapses and dropouts). Results Patients were mainly males ( n = 95) with a mean age of 24.97 (SD = 12.03). All patients included in this sample had individual CBT treatment in relation to their problematic gaming behavior. In terms of patients who relapsed, they had higher interpersonal sensitivity, hostility and persistence with lower self-directedness. Patients who dropped out were males with an older age of IGD onset. When looking at treatment noncompliance, it was related to higher psychoticism and reward dependence, and lower cooperation. Patients with IGD show higher levels of treatment noncompliance. Conclusion These findings evidence a positive and promising effect of CBT on IGT. The factors identified as predictors of good and poor treatment outcomes should be considered for developing new evidence-based interventions focused on learning healthier key coping strategies to manage both cravings and triggers.

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Gaming Convergences with Other Digital Technologies: Gambling, Pornography, Social Media, and Streaming

December 2024

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75 Reads

This chapter explores the convergence of various digital technologies and their potential impacts on problematic online behaviors. Incorporation of gaming elements into many online activities (e.g., gambling, on-demand video streaming, social media, and pornography) has created concerns about problematic use, particularly among youth). We review the current state of knowledge, which suggests that problematic engagement in different activities represents distinct conditions. Nonetheless, despite their apparent distinctiveness, online addictive activities have shared risk factors, including personality factors, comorbid psychopathological symptoms, cognitive processes, and neurobiology. A common approach to prevention is therefore sensible, even if treatment of problematic cases should follow individualized approaches. Approaches actively involving parents are encouraged. We call for expanded research on the impact of specific design features of online activities on problematic behavior and risk, particularly relating to gamified activities. Longitudinal research is needed to better understand the use and impacts of online activities across developmental stages. Given the limited understanding of long-term impacts and the dynamic nature of related technologies, greater evidence is needed to inform policy and regulation relating to exposure of children and adolescents to content and activities that might in some cases promote problematic behaviors.


Online Gambling in Youth

December 2024

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299 Reads

This chapter summarizes the current literature on gambling and gambling disorders among youth. The emergence of online gambling, together with the legalization, social acceptance, and appearance of new forms of gambling or gambling-related factors, such as internet gambling, daily fantasy sports, and sports betting or loot boxes, may raise particular concerns for vulnerable populations. Adolescents are at a developmental stage characterized by increased autonomy, identity formation, social exploration, and brain development and often have high levels of sensation-seeking and impulsivity. As such, addictive or problematic engagement in gambling may have significant impacts on developmental trajectories in youth. This manuscript summarizes current knowledge, includes considerations for future research to help address current limitations in knowledge, and provides recommendations focused on the prevention of youth gambling behaviors and gambling problems in the current and evolving digital environment.


Comorbidity of Food Addiction and Behavioral Addictions

November 2024

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10 Reads

Since the last edition of the Handbook of Food and Addiction, published in 2012, research on this topic has progressed in many ways. Evidence is growing that certain foods, particularly highly processed foods with high levels of refined carbohydrates and/or added fats, can trigger addictive processes. Ultra-processed versions of these products may be even more addictive given the addition of flavor enhancers and additives that can make them intensely palatable, and are inexpensive, accessible, and highly convenient. In this edition, top researchers discuss groundbreaking science across biological, psychological, social, and policy domains that probe the role of addictive mechanisms in food intake and health. Future research questions are highlighted, including the impact of addictive foods on children, the role of the gut microbiome, the contribution of food insecurity, and the development of novel interventions to address the addictive impact of food. Potential policy and legal approaches are considered based on available science.


Food Addiction and Obesity Treatment Outcomes

November 2024

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8 Reads

Since the last edition of the Handbook of Food and Addiction, published in 2012, research on this topic has progressed in many ways. Evidence is growing that certain foods, particularly highly processed foods with high levels of refined carbohydrates and/or added fats, can trigger addictive processes. Ultra-processed versions of these products may be even more addictive given the addition of flavor enhancers and additives that can make them intensely palatable, and are inexpensive, accessible, and highly convenient. In this edition, top researchers discuss groundbreaking science across biological, psychological, social, and policy domains that probe the role of addictive mechanisms in food intake and health. Future research questions are highlighted, including the impact of addictive foods on children, the role of the gut microbiome, the contribution of food insecurity, and the development of novel interventions to address the addictive impact of food. Potential policy and legal approaches are considered based on available science.


Food Addiction and Treatment of Eating Disorders

November 2024

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2 Reads

Since the last edition of the Handbook of Food and Addiction, published in 2012, research on this topic has progressed in many ways. Evidence is growing that certain foods, particularly highly processed foods with high levels of refined carbohydrates and/or added fats, can trigger addictive processes. Ultra-processed versions of these products may be even more addictive given the addition of flavor enhancers and additives that can make them intensely palatable, and are inexpensive, accessible, and highly convenient. In this edition, top researchers discuss groundbreaking science across biological, psychological, social, and policy domains that probe the role of addictive mechanisms in food intake and health. Future research questions are highlighted, including the impact of addictive foods on children, the role of the gut microbiome, the contribution of food insecurity, and the development of novel interventions to address the addictive impact of food. Potential policy and legal approaches are considered based on available science.


Citations (43)


... Understanding the neurocognitive profiles in individuals with AN, BN, BED, OSFED, and HW is crucial for developing effective treatment interventions. In a very recent Delphi consensus paper [149], improving cognitive flexibility and impulse control were identified by researchers, clinicians, careers, and those with lived experience as key targets for ED treatments. In AN, potential deficits in cognitive flexibility, attentional biases, and emotional processing difficulties reveal specific targets for therapy. ...

Reference:

A Narrative Review on the Neurocognitive Profiles in Eating Disorders and Higher Weight Individuals: Insights for Targeted Interventions
Treatment Targets and Strategies for Eating Disorders Recovery: A Delphi Consensus With Lived Experience, Carers, Researchers, and Clinicians
  • Citing Article
  • October 2024

International Journal of Eating Disorders

... The analysis by Mestre-Bach et al. (2024) 6 suggests a link between gambling addiction and other compulsive behaviors, such as problematic pornography use, with impulsivity playing a central role. ...

Statistical predictors of the co-occurrence between gambling disorder and problematic pornography use
  • Citing Article
  • July 2024

Journal of Psychiatric Research

... These factors have been shown to delay cognitive decline, MCI, and dementia or provide protection against the occurrence of chronic diseases such as AD. Numerous studies have evaluated the associations between the Mediterranean [6,26,27,[36][37][38][39][40][41]44,[46][47][48][49][50]54,56,57,[59][60][61][62][63][65][66][67][68][69][70][72][73][74][75][76][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][97][98][99][100][102][103][104][105][107][108][109][110][111][112][113][114][115], Nordic [29,31,116,117], and Western diets [52,79,[118][119][120] and diseases. There is a consensus on how dietary intake and patterns can explain the etiology of common diseases such as cardiovascular, metabolic, and neurodegenerative diseases. ...

Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention

Nutrition Journal

... They were able to show two distinct clusters, in which the genetics of IRrelated conditions may exert divergent pleiotropic effects: one including OCD as well as anorexia nervosa and schizophrenia, which showed negative genetic overlap with somatic IRrelated conditions, and the other one including ADHD and major depressive disorder showing positive genetic overlap with IR-related conditions [34]. In addition, a recent family-based study was able to show that relatives of individuals with a psychiatric disorder had an increased risk for T2D and, within a subpart of their study, they were able to show that genetic risk for T2D was associated with an increased risk for several psychiatric disorders, including ASD and ADHD [35]. These studies highlight the evidence for multiple genetic links between IR-related somatic diseases and ADHD, ASD, and OCD. ...

Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study

Psychological Medicine

... On this basis, I urge the FREED approach (not necessarily a formal intervention because it should become normal practice, in line with the NPT) to be served equally to ED sufferers of all ages and DOIs. This would be more cost-effective in the long term because rapid/ early interventions reduce the likelihood of patients needing longer and repeated interventions [23]. Importantly, this is true for patients of all ages/DOIs-ED sufferers do not suddenly become 'treatment-resistant' to rapid/early interventions (and other treatments) on their 25th birthdays, in the same way that they do not suddenly become 'terminal' on their 30th birthdays (a possibility suggested by the proposed criteria for 'terminal anorexia nervosa') [7]. ...

Quantifying the economic value of earlier and enhanced management of Anorexia Nervosa for adults in England, Germany and Spain: improving the care pathway

European Psychiatry

... The first assessed the social and financial aspects of gambling rather than addiction as a pathological construct [53]. The second one used a sample of help-seekers, which makes it difficult to draw conclusions about the general population [54]. Another study on gambling disorder and sexual addiction provided valuable information on the distinctiveness of both constructs and on the differences in the complexity of symptom networks according to gender [55]. ...

Network analysis of DSM-5 criteria for gambling disorder: considering sex differences in a large clinical sample

European Psychiatry

... In recent years, innovative therapies, such as Avatar therapy, have emerged to tackle the challenges posed by the self-critic and EDV [21]. Despite cumulative research and numerous therapeutic strategies, the efficacy and remission rates of current psychological, neurobiological, and pharmacological therapeutic approaches remain dissatisfactory [22,23]. Consequently, a universally endorsed treatment paradigm for EDs is currently lacking, even within the official practice guidelines of the American Psychiatric Association [24] and the British Psychological Society [25], given the variability in therapeutic interventions and distinct types of EDs. ...

Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives
  • Citing Article
  • March 2024

Trends in Molecular Medicine

... A unique feature of our approach is that we start in an unbiased manner, from the (gen)omics perspective. Indeed, our current disease-level 'hypothesis' is that there is some genetic and molecular overlap between AD and the above-mentioned SID, which is in part based on our own findings that there are local [24] rather than global [23] genetic correlations between AD and SID. To this end, we integrated the latest available genomewide association studies (GWASs) of AD as well as D2M, MES and OBS, and compiled a list of genes relevant for both AD and SID, based on gene-based analyses, functional annotation and expression quantitative trait loci (eQTL) mapping. ...

Local patterns of genetic sharing challenge the boundaries between neuropsychiatric and insulin resistance-related conditions

... For one, obesity-related insulin resistance impacts several brain regions, including the hippocampus and prefrontal cortex, which are important for memory function [6,9]. Further, proposed IR-related pathways that affect memory function are vascular brain injury, impaired brain glucose metabolism, inflammation, oxidative stress, and higher tau biomarkers [6,7,10]. Despite the established link between IR and cognitive function, specific mechanisms remain unclear. ...

The association of glucose metabolism measures and diabetes status with Alzheimer’s disease biomarkers of amyloid and tau: A systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews

... In recent years, neuromodulation techniques such as transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (Gallop et al. 2022), innovative psychotropic drugs such as metreleptin (Hebebrand et al. 2024), ketamine, psilocybin , the glucagon-like-peptide-1 (GLP-1) receptor agonists (Himmerich and McElroy 2024), the combination of pharmacological treatment with specific dietary strategies, for example ketamine plus ketogenic diet (Calabrese et al. 2022;Scolnick and Beckwith 2023), and microbiome-based treatments with pre-and probiotics (Baenas et al. 2024;Nicol et al. 2024;Gröbner et al. 2022;Keller et al. 2022) have raised our hopes of therapeutic improvements for the people with EDs ). The collection "Biological Therapies and EDs" provides an insight into some of these novel and promising treatment strategies. ...

Probiotic and prebiotic interventions in eating disorders: A narrative review
  • Citing Article
  • January 2024

European Eating Disorders Review