Fernanda Bellotti Formiga’s research while affiliated with Irmandade da Santa Casa da Misericórdia de Santos and other places

... Seown-En et al. [34] führten bei 12 TaTME-Patienten mit Karzinomen im unteren Rektumdrittel eine verzögerte handgenähte Anastomose durch und fanden in der gematchten Vergleichsgruppe funktionell (Wexner-und LARS-Score) keinen signifikanten Unterschied zur laparoskopischen und robotischen TME mit primärer koloanaler Stapler-Anastomose. Eine aktuellere Metaanalyse konnte für die verzögerte Anastomose nach onkologischer tiefer anteriorer Resektion auch eine signifikant niedrigere Insuffizienzrate nachweisen (15,4 % vs. 23,5 %; OR 0,55; 95 % KI 0,31-0,97; p = 0,04; [35]). ...

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Intersphinktäre Resektion zum Schließmuskelerhalt beim ultratiefen Rektumkarzinom – Ein UpdateIntersphincteric resection for sphincter preservation in ultra-low rectal cancer—An update

... LPS-induced TLR4 expression reversed depot-specific variation, and increased p65 levels in both explants were associated with the overexpression of IL-1β. Together, the results indicate that adipose tissue in CAC is involved in inflammation and its depot-specific regulation [27]. ...

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Immune System Disorder and Cancer-Associated Cachexia

... Postoperative mortality did not significantly differ among the four periods, consistent with international studies [1,20,30,31,[33][34][35][36][37]. This is also consistent with the research of Vicente et al., who suggests that during this period, surgical intervention for the treatment of colon cancer can be performed without a significant impact on postoperative mortality [38]. Despite this, variations in parameters influencing patient prognosis were identified. ...

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Assessing Changes in Colon Cancer Care during the COVID-19 Pandemic: A Four-Year Analysis at a Romanian University Hospital

... Cancer-associated inflammation includes both local and systemic inflammation, with these two forms interacting in the development and progression of cancer, significantly impacting patient survival outcomes. Local inflammation typically manifests as immune responses within the tumor microenvironment, promoting tumor cell proliferation, migration, and drug resistance, while systemic inflammation exacerbates immune suppression throughout the body by releasing various inflammatory factors, such as TNF-α and IL-6, further promoting tumor metastasis and recurrence [18][19][20]. C-reactive protein (CRP), as a marker of systemic inflammation, holds substantial value in determining the prognosis of cancer patients [21]. Building on this, other important indices based on CRP, such as the Lymphocyte/CRP ratio (LCR), CRP × neutrophil/lymphocyte ratio (IBI), and CRP/albumin ratio (CAR), have demonstrated even greater prognostic value than CRP alone [8,22]. ...

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NCR as a biomarker for nutritional status and inflammation in predicting outcomes in patients with cancer cachexia: a prospective, multicenter study

... 6 Acadêmico de Medicina pela Universidade Federal do Amapá. 7 Cirurgião Coloproctologista pela Real e Benemérita Sociedade Portuguesa de Beneficência do Rio de Janeiro. 8 ...

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TRATAMENTO DE MELANOMA DE CANAL ANAL COM CIRURGIA DE MILES: UM RELATO DE CASO NA AMAZÔNIATREATMENT OF ANAL CANAL MELANOMA WITH MILES SURGERY: A CASE REPORT IN THE AMAZON

... Over 90% of MLGs are located between the labia minora or majoria [2]. Less than 20 cases of anal HP have been reported in the literature [7]. ...

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Hidradeonoma Papilliferum of the Anus: A Case Report About the Relationship Between Neoplasms of the Mammary-Like-Glands and Hormones

... Anorectal surgery requires adequate anesthesia due to its multiple nerve supply [9]. Painful stimuli can be blocked either with regional or general anesthesia (GA), usually with muscle relaxants [8]. Different studies have suggested that switching from GA or regional anesthesia like saddle block and or spinal anesthesia to local infiltration or perianal block (PAB) may prove advantageous for proctologic surgeries [17]. ...

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Pain assessment following open hemorrhoidectomy under local anesthesia versus saddle block: a multicenter randomized controlled trial

... Kim et al. [10] also reported an overall agreement of 63% between the clinical and pathological assessments. Other investigators [15] compared the clinical and pathologic N stages based on the receipt of neoadjuvant therapy. While patients who proceeded directly to surgery had an accuracy of MRI in determining lymph node involvement equal to 82.7%, close to our result, the accuracy was reduced by 21% in patients who received neoadjuvant therapy. ...

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Concordance between clinical and pathologic assessment of T and N stages of rectal adenocarcinoma patients who underwent surgery without neoadjuvant therapy: A National Cancer Database analysis

... The rate of non-closure of the defunctioning stoma in our group was 19.8%, similar to that found by other authors who described a rate of 18% to 36%. 4,7,13,15,[17][18][19][20] The mean time of closure was 8.7 months. This number is above the mean value found in international literature, ranging from 4.1 to 5.9 months 4,7,13 and coincides with the mean time found in national studies, of 12 months. ...

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Predictive factors for temporary defunctioning stoma permanence in the treatment of rectal adenocarcinoma

... PJS is associated with a 15-fold increased relative risk of malignancies compared to the general population [12]. Colonic cancer (57 %), accounts for the majority of neoplasm in patients with PJS, followed by breast (45 %), pancreatic (36 %), stomach (29 %), ovary (21 %), small intestine (13 %), and uterine (10 %) tumors [13]. Some extragastrointestinal epithelial malignancies of the lungs, thyroid, and ovaries are also reported. ...

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Peutz-Jeghers syndrome in women with jejunojejunal intussusception and multiple gastrointestinal polyposis: A case report