Feng Xie's research while affiliated with McMaster University and other places
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Publications (297)
Introduction
The EQ-5D is a widely used health-related quality of life (HRQoL) instrument. The recall period “today” may miss out on recurrent health fluctuations often observed in people with dementia (PlwD). Thus, this study aims to assess the frequency of health fluctuations, affected HRQoL dimensions and the impact of the health fluctuations on...
Background:
TP53 mutations, which are present in 5% to 10% of patients with acute myeloid leukemia (AML), are associated with treatment resistance and poor outcomes. First-line therapies for TP53-mutated (TP53m) AML consist of intensive chemotherapy (IC), hypomethylating agents (HMA), or venetoclax combined with HMA (VEN + HMA).
Methods:
We cond...
Objectives:
To gain insight into formal methods of integrating patient preferences and clinical evidence to inform treatment decisions, we explored patients' experience with a personalised decision analysis intervention, for prophylactic low-molecular-weight heparin (LMWH) in the antenatal period.
Design:
Mixed-methods explanatory sequential pil...
Objective
In Canada, population norms are only available for 2 provinces, Alberta and Quebec. The objective of this study was to derive the population norms for the EQ-5D-5L based on a representative sample of the Canadian general population.
Methods
Data from the Canadian EQ-5D-5L valuation study, a cross-sectional study, were used. A quota sampl...
Background:
Value assessment frameworks (VAFs) are promising tools for measuring the value of health technologies and informing coverage policymaking; however, most published VAFs were developed for high-income countries. This study aimed to identify value attributes as part of the development of a VAF in China.
Methods:
We used the qualitative...
Objective:
Cost effectiveness analysis (CEA) has been increasingly used to inform cancer treatment coverage policy making worldwide. The primary objective of this study was to assess the association between industry sponsorship and CEA results in oncology.
Study design and setting:
All CEAs in oncology used incremental cost per quality-adjusted...
Background
Venous thromboembolism (VTE) in pregnancy is a major cause of maternal morbidity and death. The use of low-molecular-weight heparin (LMWH), despite being the standard of care to prevent VTE, comes with some challenges. Shared decision-making (SDM) interventions are recommended to support patients and clinicians in making preference-sensi...
Objectives
To determine demographic, socioeconomic, and clinical factors associated with being high-cost users (HCUs) in adult patients (≥ 18 years) who received acute care in Canada.Research designWe conducted a retrospective study among adults who had at least one encounter with acute care facilities each year from 2011 to 2014 using national lin...
Background
The global incidence of myelodysplastic syndromes (MDS) has been estimated as 0.06 to 0.26/100,000. Since their introduction, hypomethylating agents have played a central role in the treatment of MDS, with heterogeneous real-world outcomes.
Materials and Methods
We assessed and synthesized clinical outcomes of azacitidine (AZA) monother...
Abstract
Purpose
We sought to compare the cost-effectiveness of probiotics and usual care with usual care without probiotics in mechanically ventilated, intensive care unit patients alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT).
Methods
We conducted a health economic evaluation alongside the PR...
Background
Venous thromboembolism (VTE) in pregnancy is an important cause of maternal morbidity and mortality. Low-molecular-weight heparin (LMWH) is the cornerstone of prophylaxis and treatment of thrombotic events during pregnancy. LMWH has fewer adverse effects than other anticoagulants, does not cross the placenta, and is safe for the fetus. H...
Background:
Assessing health-related quality of life (HRQoL) among persons with dementia poses several challenges due to cognitive decline and limited perception. As a result, proxy ratings by family members or health professionals are used. The EQ-5D is the most commonly used generic and preference-based HRQoL instrument. Methodological drawbacks...
Objective
Excess gestational weight gain (GWG) is associated with adverse long and short-term outcomes for both woman and child, yet evidence demonstrates pregnant women are frequently not engaging in healthy behaviours linked to appropriate weight gain. The purpose of the current study was to explore women’s values and beliefs related to weight, n...
Objectives
This study evaluated the psychometric properties of the Mandarin version of the HeartQoL questionnaire, a core ischemic heart disease (IHD) health-related quality of life (HRQL) instrument, in patients with angina, myocardial infarction (MI), and ischemic heart failure (IHF).
Methods
The English version of HeartQoL was translated into M...
Aim:
Whether or not use of intravenous alteplase in combination with endovascular thrombectomy (EVT) improves outcomes versus EVT alone, for acute stroke patients with large vessel occlusion presenting directly to a comprehensive stroke center, is uncertain.
Methods:
Six randomized trials exploring this issue were published, and we synthesized t...
Objectives
Health Utilities Preschool (HuPS) was developed to fill the need for a generic preference-based measure (GPM) applicable in early childhood. A GPM has all the properties for higher-order summary measures, such as quality-adjusted life-years, required to inform important policy decisions regarding health and healthcare services.
Methods...
BACKGROUND
Atherosclerotic cardiovascular diseases (CVDs) are leading causes of death despite effective therapies and result in unnecessary morbidity and mortality throughout the world. We aimed to investigate the cost-effectiveness of polygenic risk scores (PRS) to guide statin therapy for Canadians with intermediate CVD risk and model its economi...
Background and objectives:
Existing generic preference-based measures were all developed in Western countries. Evidence shows that the Chinese population may have different perceptions about health and health-related quality of life. This study aimed at developing a descriptive system of a new generic preference-based measure under the initiative...
Mortality is a well-established patient-important outcome in critical care studies. In contrast, morbidity is less uniformly reported (given the myriad of critical care illnesses and complications of each) but may have a common end-impact on a patient’s functional capacity and health-related quality-of-life (HRQoL). Survival with a poor quality-of-...
Background: Venous thromboembolism (VTE) in pregnancy is an important cause of maternal morbidity and mortality. Low-molecular-weight heparin (LMWH) is the cornerstone of prophylaxis and treatment of thrombotic events during pregnancy. LMWH has fewer adverse effects than other anticoagulants, does not cross the placenta, and is safe for the fetus....
Background
Pregnancy induces bone mineral mobilization, which may be further compromised if diet and physical activity are sub-optimal.
Objectives
We aimed to determine the effects of a Nutrition + Exercise intervention during pregnancy on maternal calciotropic and bone biomarker profiles throughout pregnancy and the postpartum.
Design
In the Be...
Objective:
To assess the association between industry sponsorship (drug, medical device, and biotechnology companies) and cost effectiveness results in cost effectiveness analysis (CEA).
Design:
Registry based analysis DATA SOURCE: The Tufts Cost-Effectiveness Analysis Registry was used to identify all CEAs published in Medline between 1976 and...
e19062
Background: AZA is a standard of care for patients who have HR-MDS. Given the limited availability of large datasets describing outcomes in the current treatment paradigm of HR-MDS, this analysis aimed to aggregate clinical outcomes associated with AZA monotherapy for treatment-naïve HR-MDS. Methods: CENTRAL, EMBASE, and MEDLINE were searche...
Objectives
This study aimed to compare the treatment preference among oncologists, patients with lung cancer, and their family members in China.
Methods
A face-to-face discrete choice experiment survey was conducted among oncologists, patients, and their family members. Participants completed 13 choice sets describing 6 key attributes, namely, ove...
e19020
Background: TP53 mutations are present in 10%–15% of patients with acute myeloid leukemia (AML) and are associated with resistance to therapy and poor outcomes. Currently available frontline therapies for TP53-mutated ( TP53m) AML include intensive chemotherapy (IC), hypomethylating agents (HMA), and venetoclax combined with HMA (VEN+HMA). T...
The disruptions to health research during the COVID-19 pandemic are being recognized globally, and there is a growing need for understanding the pandemic’s impact on the health and health preferences of patients, caregivers, and the general public. Ongoing and planned health preference research (HPR) has been affected due to problems associated wit...
Introduction
Glaucoma is a progressive, chronic condition that can have a significant impact on a patient’s health-related quality of life (HRQoL). Validated, disease-specific HRQoL tools such as the Health Utility for Glaucoma (HUG-5) tool and the Glaucoma Quality of Life Questionnaire (GlauQoL-17) can be used to monitor a patient’s quality of lif...
Objective
GRADE practice guideline developers often perform systematic reviews of potential economic evaluations to inform recommendation decision-making. We aimed to identify indirectness characteristics of economic evaluations, related to GRADE evidence-to-decision (EtD) theoretical frameworks, that influence selection of these articles.
Study D...
Background:
Changes over time in health state values from a societal perspective may be an important reason to consider updating societal value sets for preference-based measures of health.
Objective:
The aim was to examine whether stated health preferences are different between 2002 and 2017, controlling for demographic changes in the United St...
Background
To investigate the mortality and health care resource use among patients with severe or critical coronavirus disease of 2019 (COVID-19) in the first wave of pandemic in China.
Methods
We performed a systematic review and meta-analysis to investigate the mortality, discharge rate, length of hospital stay, and use of invasive ventilation...
Background
We examined the characteristics and outcomes in a contemporary ambulatory population of patients with atrial fibrillation (AF) comparing rate and rhythm control.
Methods
This is a post-hoc analysis of a cluster randomized trial (IMPACT-AF) in ambulatory AF patients from 2016-18, which compared a clinical decision support tool for genera...
Introduction
The Grading of Recommendations Assessment, Development and Evaluation (GRADE) and similar Evidence to Decision (EtD) frameworks require its users to judge how substantial the effects of interventions are on desirable and undesirable people-important health outcomes. However, decision thresholds (DTs) that could help understand the magn...
A randomized two-arm prospective superiority trial tested the efficacy of a novel structured and monitored nutrition (bi-weekly counselling for individualized energy and high dairy protein diet) and exercise program (walking goal of 10,000 steps/day) (intervention) compared to usual care (control) in pregnant women to achieve gestational weight gai...
Background:
Retrospective data demonstrates that robotic-assisted thoracoscopic surgery provides many benefits, such as decreased postoperative pain, lower mortality, shorter length of stay, shorter chest tube duration, and reductions in the incidence of common postoperative pulmonary complications, when compared to video-assisted thoracoscopic su...
Objectives:
To derive the population norms for EQ-5D-5L and SF-6Dv2 among the Chinese general population.
Methods:
Data collected alongside the Chinese SF-6Dv2 valuation study conducted between June and September 2019 were used. SF-6Dv2 and EQ-5D-5L, as well as social-demographic characteristics and self-reported chronic conditions, were collect...
Background:
Health utility values (HUVs) are important inputs to the cost-utility analysis of breast cancer interventions.
Purpose:
Provide a catalog of breast cancer-related published HUVs across different stages of breast cancer and treatment interventions.
Data sources:
Systematic searches of MEDLINE, MEDLINE In-Process, EMBASE, Web of Scie...
Background: Assessing health-related quality of life (HRQoL) among persons with dementia poses several challenges due to cognitive decline and limited perception. As a result, proxy ratings by family members or health professionals are used. The EQ-5D is the most commonly used generic and preference-based HRQoL instrument. Methodological drawbacks...
Background: Triple normal lymph nodes (LNs), appearing
benign on computed tomography, positron emission tomography and endobronchial ultrasonography (EBUS), have a less
than 6% probability of malignancy. We hypothesized that targeted sampling (TS), which omits biopsy of triple normal LNs
during EBUS, is not an inferior staging strategy to systemati...
OBJECTIVE)
Triple Normal lymph nodes, appearing benign on CT, PET, and endobronchial ultrasound, have <6% probability of malignancy. We hypothesized that Targeted Sampling (TS), which omits biopsy of Triple Normal lymph nodes during endobronchial ultrasound, is not an inferior staging strategy to Systematic Sampling (SS) of all lymph nodes.
METHO...
Eltrombopag has been shown to be non-inferior to intravenous immunoglobulin (IVIG) for improving perioperative platelet counts in patients with immune thrombocytopenia (ITP) in a randomized trial; thus, cost is an important factor for treatment and policy decisions. We used patient-level data from the trial to conduct a cost-effectiveness analysis...
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with...
Objective
This study aims to determine how population-based health-utility score (HUS) differences reflect individuals’ health preferences using responses from the Canadian EQ-5D-5L Valuation Study, including time trade-off (TTO) and discrete-choice experiment (DCE) tasks (n=1073).
Study Design and Setting
Cardinal TTO responses were transformed i...
Background
Patient reported outcomes (PROs) are important measures of health, particularly in symptomatic conditions such as heart failure (HF), and regulatory agencies have encouraged their collection in randomized controlled trials (RCTs).
Purpose
To assess temporal trends in the inclusion of patient-reported outcomes (PROs) in heart failure (HF...
Objective:
To explore and characterize published evidence on the ways decision analysis has been used to inform shared decision-making.
Study design and setting:
For this scoping review, we searched five bibliographic databases (from inception until February 2021), reference lists of included studies, trial registries, a thesis database and webs...
Background:
Since the outbreak of coronavirus disease 2019 (COVID-19), human mobility restriction measures have raised controversies, partly because of the inconsistent findings. An empirical study is promptly needed to reliably assess the causal effects of the mobility restriction. The purpose of this study was to quantify the causal effects of h...
Importance
Data on the long-term health care expenditures associated with bariatric surgery consisting of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy are lacking.
Objective
To compare 4-year health care expenditures after RYGB vs sleeve gastrectomy, identify factors independently associated with 4-year health care expenditures, and comp...
Objectives
This study aimed to investigate how value is defined and measured in existing value assessment frameworks (VAFs) in healthcare.
Methods
We searched PubMed, Embase, the Cochrane Library, and Centre for Reviews and Dissemination from 2008 to 2019. We also performed backward citation chaining of included studies and previously published sy...
Background
Integrated Management Program Advancing Community Treatment of Atrial Fibrillation (IMPACT-AF) was a pragmatic, cluster randomized trial assessing the effectiveness of a clinical decision support (CDS) tool in primary care, Nova Scotia, Canada. We evaluated if CDS software versus Usual Care could help primary care providers (PCPs) delive...
Background
The IMPACT‐AF (Integrated Management Program Advancing Community Treatment of Atrial Fibrillation) trial is a prospective, randomized, cluster design trial comparing atrial fibrillation management with a computerized clinical decision support system with usual care (control) in the primary care setting of Nova Scotia, Canada. The objecti...
Aims
We assessed the effect of transitional care on patient reported outcomes (PROs) in women and men hospitalized for heart failure (HF).
Methods
In this sex-specific analysis of a cluster randomized trial in Canada, the effect of a patient-centered transitional care model was tested on prespecified PROs of discharge preparedness (B-PREPARED scor...
Background:
Assessing health-related quality of life in dementia poses challenges due to patients' cognitive impairment. It is unknown if the newly introduced EQ-5D five-level version (EQ-5D-5L) is superior to the 3-level version (EQ-5D-3L) in this cognitively impaired population group.
Objective:
To assess the psychometric properties of the EQ-...
Background
Published health utility studies are increasingly cited in cost–utility analyses to inform reimbursement decision-making. However, there is limited guidance for investigators looking to systematically evaluate the methodological quality of health utility studies or their applicability to decision contexts.Objective
To describe how health...
Objective: The goal of this study was to develop an approach that can be used where baseline risk estimates that are directly applicable to prioritized patient-important outcomes are not available from published studies.
Study design: The McMaster University GRADE Centre and the ASH guideline panel for the prevention of VTE in surgical patients dev...
Background
Evaluating the relevance of published health utilities to the context of a cost-utility analysis (CUA) remains an essential, yet often overlooked, task.Objective
The objective of this study was to provide guidance on this process through the development of the Health utility Application Tool (HAT).Methods
We conducted semi-structured tel...
e18621
Background: Understanding the health-related quality of life (HRQOL) of breast cancer during treatment and survivorship is important; however, little data are available - particularly for long-term ( > 5 year) survivors. Health utility scores anchored between 0 (death) and 1 (perfect/best possible health) have been shown to be a good proxy i...
Objective: Little is known about how developers and panel members report cost and cost effectiveness considerations in GRADE guideline Evidence-to-Decision (EtD) frameworks. A systematic survey was conducted to explore approaches and factors contributing to variability in economic information reporting.
Study Design and Setting: Guideline organizat...
Background
Patient‐reported outcomes (PROs) are important measures of treatment response in heart failure. We assessed temporal trends in and factors associated with inclusion of PROs in heart failure randomized controlled trials (RCTs).
Methods and Results
We searched MEDLINE, Embase, and CINAHL for studies published between January 2000 and July...
Background:
Colorectal cancer (CRC) screening is cost-effective in many Western countries, and many have successfully implemented CRC screening programs. For countries with a lower CRC incidence, like Saudi Arabia, the value of CRC screening is less evident and requires careful weighing of harms, benefits, and costs.
Methods:
We used the MISCAN-...
Background
Health utilities are commonly used as quality weights to calculate quality-adjusted life years in cost-utility analysis (CUA). However, if published health utilities are not properly used, the credibility of CUA could be affected.
Objectives
To identify discrepancies in using published health utilities in CUAs for cardiovascular disease...
Background:
Cancer treatment decision-making often needs to balance benefits, harms, and costs. This study sought to identify the differences in cancer treatment preference among oncologists, patients and their family members in China.
Methods:
A semi-structured face-to-face qualitative interview was conducted among oncologists, patients and the...
Background:
The COVID-19 pandemic has resulted in negative impacts on the economy, population health, and health-related quality-of-life (HRQoL).
Objective:
To assess the impact of COVID-19 on US population HRQoL using the EQ-5D-5L.
Design:
We surveyed respondents on physical and mental health, demographics, socioeconomics, brief medical histo...
Introduction
Decision analysis is a quantitative approach to decision making that could bridge the gap between decisions based solely on evidence and the unique values and preferences of individual patients, a feature especially important when existing evidence cannot support clear recommendations and there is a close balance between harms and bene...
Importance:
Mobile integrated health care (MIH) is a new model of community-based health care to provide on-site urgent or nonurgent care. Niagara emergency medical services (NEMS) started MIH in 2018 to serve the Niagara region of Ontario, Canada. However, its economic impact is unknown.
Objective:
To compare time on task and cost between MIH a...
Objectives:
Cost utility analyses compare the costs and health outcome of interventions, with a denominator of quality-adjusted life year, a generic health utility measure combining both quality and quantity of life. Cost utility analyses are difficult to compare when methods are not standardized. It is unclear how cost utility analyses are measur...
Background
Generic preference-based measures (PBM), though commonly used, may not be optimal for use in economic evaluations of breast cancer interventions. No breast cancer-specific PBM currently exists, and the generic PBMs fail to capture the unique concerns of women with breast cancer (e.g., body image, appearance, treatment-specific adverse ef...
PurposeThe EQ-5D-5L is a commonly used instrument for assessing the utility of different health states. Health state utility values are a key component of health technology evaluations. Such evaluations are used to support evidence-based decisions surrounding health resource allocations and therefore rely on the accuracy of the valuation set used....
Introduction
High-cost users (HCUs) account for a small proportion of the population but use a disproportionately large share of healthcare resources. Although HCUs exist in all healthcare types, acute care is the most expensive type of service and the most significant contributor to expenditures among HCUs. This study aims to determine demographic...
Background: In addition to health and economic consequences, the COVID-19 pandemic has likely affected population health-related quality of life (HRQoL).
Objective: To assess the impact of COVID-19 on US population health using the EQ-5D-5L.
Design: We surveyed respondents on health status, employment, and anxiety/depression. We collected informati...
Background: The COVID-19 pandemic has resulted in negative impacts on the economy, population health, and health-related quality-of-life (HRQoL).
Objective: To assess the impact of COVID-19 on US population HRQoL using the EQ-5D-5L.
Design: We surveyed respondents on physical and mental health, demographics, socioeconomics, brief medical history, c...
Importance
Results of previous studies are mixed regarding the economic implications of a Roux-en-Y gastric bypass (RYGB).
Objective
To assess the 5-year incremental health care use and expenditures after RYGB.
Design, Setting, and Participants
This population-based cohort study conducted in Ontario, Canada, used a difference-in-differences appro...
Objective Since the outbreak of novel coronavirus pneumonia (COVID-19), human mobility restriction measures have raised controversies, partly due to inconsistent findings. Empirical study is urgently needed to reliably assess the causal effects of mobility restriction.
Methods Our study applied the difference-in-difference (DID) model to assess dec...
Outcomes in economic evaluations, such as health utilities and costs, are products of multiple variables, often requiring complete item responses to questionnaires. Therefore, missing data are very common in cost-effectiveness analyses. Multiple imputations (MI) are predominately recommended and could be made either for individual items or at the a...
Excess gestational weight gain is associated with short‐ and long‐term pregnancy complications. Although a healthy diet and physical activity during pregnancy are recommended and shown to reduce the risk of complications and improve outcomes, adherence to these recommendations is low. The aims of this study were to explore women's view of nutrition...
Introduction Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and Clostridioides difficile–associated diarr...
Introduction. The EQ-5D-5L valuation protocol contains both time tradeoff (TTO) tasks and discrete choice experiments (DCE), raising the question of how to best use these in creating a value set. The hybrid model, which combines TTO and DCE data, has emerged as a commonly used approach. However, this model assumes independence among respon