Federica Cavallo's research while affiliated with Università degli Studi di Siena and other places

... Both the GSH conjugation and its subsequent depletion were believed to induce a free radical accumulation as well as the potentiality of morphine metabolites to induce, directly and indirectly, the cellular toxicity with the enzymatic inactivation, the DNA damage and/or the lipid peroxidation. (21) In respect to the periductal fibrosis and inflammation caused by tramadol administration seen in the present study they may be comparable with the morphine sulphate-induced portal-tract fibrosis, bile ductal dilatation and the proliferation of clusters of inflammatory cells surrounding the portal area. (22) These pathological changes in the liver are reminiscent with similar changes in the present study noted with the parotid gland simulating the periductal collagen fibrosis, venous or lymphatic dilations as well as the proliferation of inflammatory cells replacing the degenerated acini. ...

... For example, Saitoh et al demonstrated that the DOR1 agonist KNT-127 has a lower potency to induce convulsion than SNC80 (Saitoh et al. 2011). The DOR1 agonists TAN-67 and DPDPE did not induce seizures themselves (Tortella et al. 1984;Yajima et al. 2000), whereas the DOR2 agonist deltorphin II does (Capasso and Cavallo 2005;Di Giannuario et al. 2001). DOR1-but not DOR2-selective ligands modulate the ability of the antiepileptic drug zonisamide to alleviate Parkinson's symptoms (Yamamura et al. 2009). ...

... Previously, a higher level of oxidative stress in patients with liver dysfunction has been reported [21][22][23]. Garlic has a positive effect on the antioxidant system via activation of NF-E2-related factor-2 (Nrf-2)/heme oxygenase 1 (HO-1) pathway [24,25]. Activation of the Low risk Some concerns High Risk Fig. 2 Risk of bias assessment antioxidant system prevents hepatocyte cell degradation, and consequently, liver enzymes do not increase in the bloodstream [26]. ...

... A B. suaveolens possui efeitos semelhantes a outras plantas psicotrópicas, e comumente é comparada com os efeitos da Cannabis sativa. Estudos relataram a afinidade com receptores serotoninérgicos (5-HT1A e 5-HT2C) e dopaminérgicos (D1 e D2) e, associando resultados de trabalhos anteriores (Capasso & De Feo, 2002), sugeriram a sua capacidade de atuar como antagonista dopaminérgico (Nencini et al., 2006). As propriedades neurotóxicas da planta já foram descritas e muitos estudos também evidenciam o seu potencial genotóxico e mutagênico (Dickel et al., 2010;Santos et al., 2020). ...

... The loss of cell viability following the use of thymol has been attributed to apoptosis death via the overexpression of p53 and Bax. Interestingly, various types of studies revealed that multiple compounds from natural sources such as quercetin, icariin, berberine, resveratrol, propolis have synergistic effects in combination with TMZ [32][33][34][35]. ...

... Dichloromethane extracts from V. wallichii significantly improve norepinephrine and dopamine amounts with no changes in serotonin amounts [59]. The effects of V. adscendens extracts on the central nervous system have been associated with the interaction with serotoninergic, dopaminergic, and noradrenergic receptors [95]. On the other hand, studies from Lee et al. [39] suggest that the antinociceptive effects of V. fauriei can be related to modulatory effects on the BDNF signaling pathway in the hippocampus and medial prefrontal cortex. ...

... Although planarians are established as an invertebrate model in regeneration, pharmacologists have used the model to study behavioral changes elicited by abused compounds [2] [3] [4] [5] [6]. Raffa and colleagues developed a quantitative method for measuring planarian locomotor activity [7] and applying the metric to phenomena related to drug use/abuse such as the development of physical dependence and withdrawal [8] [9] [10]. Planarian pharmacological behavior model is robust and sensitive, and offers unique advantages compared to rodents. ...

... nevsehirense, A. sivasicum, A. dictyoprosum, A. scrodoprosum subsp. rotundum and A. atroviolaceum) were lower than A. vineale (Tepe et al., 2005;Nencini et al., 2007). ...

... Furthermore, CEF (200 mg/kg/day) administered after daily extinction sessions reduced amphetamine-induced drug-seeking under enriched conditions and standard conditions but not in rats kept under isolated conditions (Garcia et al., 2019). Moreover, CEF attenuated amphetamine-induced hyperactivity and behavioral sensitization as well as the development of physical dependence and abstinence-induced withdrawal from amphetamine and METH using a planarian model (Rawls et al., 2008). In addition to its effect on reducing tissue glutamate and glutamine content, METH induces a significant depletion of dopamine and 5-HT in the NAc and PFC. ...