Farshid Noorbakhsh's research while affiliated with Tehran University of Medical Sciences and other places

Publications (20)

Article
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Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulator...
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Introduction Colorectal cancer (CRC) has become one of the most common cancers in recent years. Given the importance that non-coding RNAs have recently acquired in various diseases including cancers, we decided to design this study to evaluate the expression levels of circ0001955/miR-145-5p/ONECUT2 axis in CRC. Methods After bioinformatics analysi...
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Substance abuse is one of the significant problems in social and public health worldwide. Vast numbers of evidence illustrate that motivational and reinforcing impacts of addictive drugs are primarily attributed to their ability to change dopamine signaling in the reward circuit. However, the roles of classic neurotransmitters, especially dopamine...
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Objective: The phosphoinositide 3-kinase/protein kinase AKT/mammalian target of rapamycin signaling pathway is essential for proper cellular metabolism and cell growth. However, aberrant activation of this pathway has been linked to the progression and metastasis of breast cancer. Recently, the role of long non-coding RNAs in interfering with the...
Article
Many packages serve as an interface between R language and the Application Programming Interface (API) of databases and web services. There is usually a ‘one-package to one-service’ correspondence which poses challenges such as consistency to the users and scalability to the developers. This, among other issues, has motivated us to develop a packag...
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Introduction Autism spectrum disorders (ASDs) are neurodevelopmental diseases characterized by communication inabilities, social interaction impairment, repetitive behavior, as well as learning problems. Although the exact mechanism underlying this disease is still obscure, researchers believe that several factors play a significant role in its dev...
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Introduction Colorectal cancer (CRC) is one of the most frequent neoplasms in the world. Based on the emerging role of noncoding RNAs, particularly circular RNAs in pathogenesis of cancers, we designed this study to inspect the expression levels of a circ0009910-mediated regulatory pathway in colorectal cancer. Methods After bioinformatics analyse...
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Mechanical ventilation (MV) is a relatively common medical intervention in ICU patients. The main side effect of MV is the so-called “ventilator-induced lung injury” (VILI). The pathogenesis of VILI is not completely under- stood; however, it has been reported that MV might be associated with up-regulation of various inflammatory mediators within...
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This study aimed to evaluate the antioxidant capacity of phosphatidylserine liposome (PS) against oxidative stress due to cyclosporine A (CsA) and concurrent administration of PS and CsA on the attenuation of immune response. The effect of oral PS was evaluated on biochemical and oxidative renal markers and histopathology of nephrotic rats receivin...
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Alzheimer's disease (AD) is closely associated with neuroinflammation development in the brain. Co-delivery of metformin (MET) with phosphatidylserine liposomes neuroprotectant may be beneficial in ameliorating AD-related symptoms like memory impairment and inflammation. Therefore, we aimed to prepare metformin containing phosphatidylserine nanolip...
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Background: Inflammatory cytokines have been observed in colorectal cancer (CRC) tissues and can promote the susceptibility to metastasis of CRC cells. Diverse regulatory mechanisms of long ncRNAs (lncRNAs) and microRNAs (miRNAs) involved in the inflammatory responses are associated with tumor progression. The aim of this research was to investiga...
Article
Background: Superantigens can be absorbed trans-mucosal and trans-cutaneous in individuals colonized with superantigen producing Staphylococcus aureus. Ability of superantigens to activate a large numbers of T cells suggests that they may play a role in the course of autoimmune diseases including human multiple sclerosis and experimental autoimmun...
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Lateral flow immunoassay (LFIA) is the most widely used platform of the point-of-care (POC) detection. Since the most important factor in deciding the results of this technique is the visual quality of the test, it should be at its optimum. To address this issue, the present study examines optimising critical parameters to improve the quality of LF...
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The gene Nrf2 (nuclear factor‐erythroid 2‐related factor 2) is the most important regulator of the cellular antioxidant system and its dysregulation has a role in the etiology of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the association between Nrf2 targeted miRNAs (miR‐27a, miR‐142‐5p, miR‐153, and miR‐128)...
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Sulfur mustard (SM)-exposed individuals develop late pulmonary complications, which are associated with chronic inflammation and fibrotic changes in the lung tissue. MicroRNAs are known to act as important regulators of inflammatory responses, including inflammation and fibrosis-related cytokine signaling. In this study, we investigated the express...
Article
T cell exhaustion is an immunosuppressive mechanism which occurs in chronic viral infections, solid tumors and hematologic malignancies. Exhausted T cell has increased the expression of inhibitory receptors, and functional impairment. In this study, we investigated the expression from some of those inhibitory receptors being Programmed death 1 (PD-...
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Full-text available
Autophagy was shown to modulate inflammation in immune cells. This study was designed to evaluate the association between autophagy and inflammation in peripheral blood mononuclear cells (PBMCs) of type 2 diabetic (T2D) and non-diabetic (ND) subjects. The autophagy markers were measured by real-time PCR and western blot. The gene expression of pro-...
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Background: Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency (PID), characterized by heterogeneous clinical manifestations and defects in B- and T- cells. In the present study, we investigated the T helper (Th) cell subsets and regulatory T (Treg) cells, and their related cytokines and transcription f...
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Objective Adult hypothalamic neurogenesis has been considered as a central regulator of energy balance. Resveratrol (RSV), a natural polyphenol, influences the body fat mass and reduces the amount of adipose tissue. The present study was designed to evaluate the effect of RSV on dynamic of hypothalamic neurons in a diet-induced obesity model of mic...

Citations

... The Kaplan-Meier survival curve was used to evaluate the differences in OS between the two groups by the log-rank test. Additionally, the receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC value) was applied to estimate the accuracy of the prognostic signature [30]. To determine whether risk score was an independent prognostic factor, the univariate and multivariate Cox regression analyses were performed. ...
... Beyond COVID-19 treatment, the combination of lidocaine and dexamethasone analyzed in our experiments could be an interesting alternative for other pathological conditions that are driven by an exaggerated inflammatory response, such as ventilator-induced lung injury [55,56]. ...
... Antibody-based techniques for the detection of MRSA are challenging as S. aureus protein A binds to mammalian immunoglobulins. Nevertheless, the use of IgY anti-PBP2a antibodies has been described by Yamada et al. [30], and another study described an optimized LFIA with a detection limit of 10 4 cfu/mL [31]. ...
... In addition, PS could combine with others drugs or function as a drug carrier to improve AD symptoms, for example, PS combines with ferulic acid and curcumin significantly to inhibit Aβ production, phosphorylated tau, and IL1β release, and increase brain-derived neurotrophic factor and acetylcholine (Okuda et al., 2019). PS also serves as drug delivery approach for metformin and nicotinamide to ameliorate the cognitive function and inflammation (Vakilinezhad et al., 2018;Saffari et al., 2020). ...
... A meta-analysis and functional experiments on NKILA found low expression of NKILA in CC and resulted in a poor prognosis, which suggested that NKILA has a protective function in CC cell lines and tissues. This is opposite to our results [33,34]. However, Huang et al. found that NKILA could strengthen the sensitivity of tumor-specific cytotoxic T lymphocytes and TH1s to activation-induced cell death and help in the immune escape of tumor cells, suggesting that it is a risk factor, which is consistent with our results [35]. ...
... Superantigens are known to trigger the cytokine storm that can lead to immune-mediated multiple organ dysfunction syndrome, and this is often followed by immune suppression that can lead to persistent infection [101]. Superantigens such as SEB have been shown to exacerbate autoimmune disorders (i.e., experimental autoimmune encephalomyelitis and experimental multiple sclerosis) in mice models [102]. Recently, Jacobs proposed that long-COVID could be due in part to SARS-CoV-2 superantigen-mediated immune suppression, leading to persistent systemic SARS-CoV-2 infection [98]. ...
... Various noncoding RNAs including microRNAs (miR-NAs) and long noncoding RNAs (lncRNAs) involved in the regulation of Nrf2. Numerous miRNAs are widely recognized negatively regulated Nrf2 levels by targeting the 3′ untranslated region in podocytes, neuroblastoma cells, erythroid cells, and HepG2 cells, including miR-27a, miR-28, miR-34, miR-93, miR-128, miR-142-5p, miR-144, and miR-153 [75]. Increased miRNAs target Nrf2 and accelerate the degradation of Nrf2 mRNA, leading to an impaired antioxidative response [76]. ...
... Interestingly, a big cluster of miRNAs has been demonstrated to accelerate HSC activation, fibrogenesis and cancer by augmenting fibrosis-associated signaling pathways including transforming growth factor-β/Smad (19). It was reported that microRNA (miR/miRNA)-21-5p acts as a key mediator in the TGF-β1 signaling pathway through assisting in the inhibition of Smad7 expression (20,21). However, the role of the TGF-β1/miR-21-5p pathway in HSC activation and liver fibrosis remains to be elucidated. ...
... The function of immune cells in the microenvironment of the tumor significantly influences tumor outcome. There is evidence that CD244 is primarily expressed by NK cells, T cells, MDSCs, and DCs in the tumor microenvironment and that it functions in the regulation of these cells (48,(91)(92)(93). By recognizing MHC-I on the surfaces of normal cells, mature NK cells can kill tumor cells without damaging normal cells, whose function is regulated by multiple inhibitory and stimulatory signals (94). ...
... Previous studies demonstrated that PBMCs are good candidates for investigating proteins involved in autophagy. 28,29 Separation of PBMCs from whole blood was performed using the BD Vacutainer ® CPTÔ Cell Preparation Tube (Health Care Equipment and Supplies Ltd, Stains, UK). ...