Fang-Di Hu's research while affiliated with Lanzhou University and other places

Publications (19)

Article
One new tirucallane-type triterpenoid, codopitirol A (1), has been isolated from the roots of Codonopsis pilosula var. modesta (Nannf.) L. D. Shen, together with fourteen known compounds, including four triterpenoids (2–5), five steroids (6–10), one eudesmane-type sesquiterpenoid (11), one phenylpropanoid (12), one coumarin (13), and two other comp...
Article
The present study investigated the influence of heating and honey addition on the appearance, chemical component content, and pharmacological activity of Codonopsis Radix decoction pieces in the honey-frying process, and explored the processing mechanism of honey-fried Codonopsis Radix. The color, sweetness, and content of macromolecular components...
Article
Codonopsis Radix, a popular food homology medicine, is widely used in clinical traditional Chinese medicine and food supplement, raw products and three types of processed products are the main form of decoction pieces in China. However, there is no scientific basis for comprehensive chemical characterization of raw and three types of processed prod...
Article
The ethanol extract of the roots of Codonopsis pilosula was subjected to chromatographic fractionation, which result in the isolation and characterization of two new aromatic derivatives 2,3-dihydroxypropyl 2,4-dihydroxy-3,6-dimethylbenzoate (1) and 2-oxopropyl 3-hydroxy-4-methoxybenzoate (2), along with three known compounds pilosulinene A (3), po...
Article
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A new taraxerane-type triterpenoid, codopimodol A (1), together with two known triterpenoids (2 and 3), were isolated from the EtOH extract of the roots of Codonopsis pilosula var. modesta (Campanulaceae). The structure of the new compound was identified by high-resolution electrospray ionization mass spectrometry and extensive spectroscopic analys...
Article
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Objective “Same treatment for different diseases” is a unique treatment strategy under the guidance of traditional Chinese medicine (TCM) theory. Codonopsis Radix (Codonopsis pilosula, Dangshen in Chinese) with spleen-fortifying effect was employed to understand the strategy of “Same treatment for different diseases”, based on its common mechanism...
Article
In this study, the porous graphene (PG) with excellent structure was successfully prepared by a simple pyrolysis process, and applied to construct electrochemical sensor ([email protected]) for detection of calycosin (CYS). PG was characterized by Raman spectroscopy, Fourier transform infrared spectroscopy and scanning electron microscopy. Also, th...
Article
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Background: The Qing'e formula (QEF) is a well-known traditional Chinese prescription that has been clinically employed for treatment of bone disease for hundreds of years. Objective: The present study aims to observe the effects of different compatibilities of QEF on the scopolamine-induced learning and memory impairment in the mouse, and further...
Article
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Background: The dried roots of Inula helenium L. (IH) and Inula racemosa Hook f. (IR) are used commonly as folk medicine under the name of ?tumuxiang (TMX)?. Phenolic acid compounds and their derivatives, as main active constituents in IH and IR, exhibit prominent anti-inflammation effect.
Article
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An electrochemical method based on a directly electrochemically reduced graphene oxide (ERGO) film coated on a glassy carbon electrode (GCE) was developed for the rapid and convenient determination of rutin in plasma. ERGO was modified on the surface of GCE by one-step electro-deposition method. Electrochemical behavior of rutin on ERGO/GCE indicat...
Article
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The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quanti...
Article
The electrochemical behaviors of shikonin at a poly(diallyldimethylammonium chloride) functionalized graphene sheets modified glass carbon electrode(PDDA-GS/GCE) have been investigated. Shikonin could exhibit a pair of well-defined redox peaks at the PDDA-GS/GCE located at 0.681 V(E pa) and 0.662 V(E pc)[vs. saturated calomel electrode(SCE)] in 0.1...
Article
Full-text available
Graphene (G) was dispersed into 0.5% chitosan (Chit) solution, then the composite films were coated on glassy carbon electrode (GCE), the electrochemical behavior of rutin on a Chit/G modified GCE was investigated and the electrochemical parameters of rutin were calculated. Rutin effectively accumulated on the Chit/G/GCE and caused a pair of redox...
Article
Full-text available
An approach was proposed to evaluate preparation technology by means of fingerprint-peak matching technology of high Performance liquid chromatography with diode array detector (HPLC-DAD). Similarity and hierarchical clustering analysis (HCA) were applied to identify the 15 batches of Xiaochaihu granules from different manufacturers and our laborat...
Article
Full-text available
A simple and accurate high-performance liquid chromatography (HPLC) coupled with diode array detector (DAD) and evaporative light scattering detector (ELSD) was established for the determination of six bioactive compounds in Zhenqi Fuzheng preparation (ZFP). The monitoring wavelengths were 254, 275 and 328 nm. Under the optimum conditions, good sep...
Article
An accurate and sensitive high-performance liquid chromatography method is developed and applied to the determination of seven compounds in a kind of traditional Chinese medicinal preparation of Tang Maikang Granule. The method is performed on Hypersil C(18) column (250- x 4.6-mm i.d., 5 microm), and different mobile phases and detectors are select...

Citations

... In the middle processing stage, the glycosidic bonds in saponins, flavonoid glycosides, oligosaccharides, and polysaccharides could be hydrolyzed under acidic and thermal conditions. The hydrolysis and dehydration reactions could release monosaccharides and their derivatives [27,28]. In the late processing stage, further hydrolysis of polysaccharides, oligosaccharides, and monosaccharides could produce DDMP and furfural derivatives, such as 5-HMF; then, the produced ingredients and amino acids would undergo a Maillard reaction under thermal conditions, indicating the inherent relevance of carbohydrates and secondary metabolites [18,44]. ...
... Brassicaceae Nasturtium officinale R. Br [170] Myrtaceae Eucalyptus grandis [171] E. urophylla [171] Syzygium aqueum [172] S. cumini [173] Meliaceae Azadirachta indica [139] Clusiaceae Garcinia mangostana [174] Sapindaceae Nephelium lappaceum [175] Vitaceae Vitis vinifera [176] Santalaceae Osyris alba L. [177] Hypericaceae Hypericum triquetrifolium Turra [178] Ericaceae Arbutus andrachne L. [179] Vaccinium oxycoccos [180] Bignoniaceae Oroxylum indicum [123] Campanulaceae Codonopsis pilosula [181,182] Geraniaceae Geranium collinum [183] Dryopteridaceae Dryopteris cycadina [75,184] Acanthaceae Clinacanthus nutans [142] Rutaceae Orixa japonica Thunb [156] α-Amylase inhibitor Anacardiaceae Spondias pinnata (Koenig) [185] Myrtaceae Syzygium cumini L. [186] Zygophyllaceae Balanites aegyptiaca L. [187] Amaranthaceae Amaranthus caudatus L. [188] Theaceae Camellia sinensis L. Del [128] Fabaceae Galega officinalis L. [189] Tamarindus indica L. [190] Cassia auriculata [191] Apocynaceae Holarrhena floribunda [192] Melissa officinalis L. [193] Rubiaceae Mitragyna innermis (Wild.) [189] Lamiaceae Rosmarinus officinalis L. [193] Polygalaceae Securidaca longepedunculata [194] Asparagaceae Polygonatum adoratum [195] α-Glucosidase and α-amylase inhibitor Nelumbonaceae Nelumbo nuciffera Gaertn [47] Asteraceae Artemisia vulgaris L. [133] Enydra fluctuans Lour [185] Araliaceae Polyscias fruticosa (L.) Harms [196] Myrtaceae Syzygium zeylanicum (L.) DC [186] Phyllanthus urinaria [127] Lamiaceae Ocimum basilicum L. [125] Thymus serpyllum [197] Meliaceae Khaya senegalensis [198] Moraceae Artocarpus altilis [1,199] Ranunculaceae Aconitum heterophyllum [199] Acoraceae Acorus calamus [200] Berberidaceae Berberis aristata [199] Cyperaceae Cyprus rotundus [201] Calophyllaceae Mesua ferrea [186] Plumbaginaceae Plumbago zeylanicum [202] Combretaceae Terminalia arjuna [203] Myrtaceae Brazilian cerrado [204] Eugenia dysenterica [205] Stryphnodendron adstringens [206] Pouteria caimito [206] Pouteria torta [206] Pouter ramiflora [207] Psidium guajava L. [2] DPP-4 inhibitors improve βand α-cell function and decrease glucagon concentrations [208]. ...
... The traditional effects of C. pilosula in China are to strengthen the spleen, benefit the lungs, nourish the blood and promote the production of body fluid [22]. Recent research in natural medicinal chemistry has revealed that the main bioactive substances in the root of C. pilosula contain polysaccharides [23], alkaloids [24], flavonoids [25], lignans [26], polyacetylene [27,28], terpenoid [29,30], and lactones [31]. Among those, polysaccharides are one of the major active components, and related research has attracted great interest [23]. ...
... It can identify and predict its related targets, bioactive compounds, and clarify the molecular mechanism of TCM. The core concept of TCM network pharmacology is "network target, multi-component" model, which can systematically elucidate the molecular mechanism of TCM treatment of various diseases (Xu et al., 2021;He et al., 2021). At present, there have been many pharmacological studies on network, such as gegen Qinlian Decoction for the treatment of type 2 diabetes, Wumei pill for the treatment of pancreatic tumor, and Baizhu root for the treatment of osteoporosis Wan et al., 2019;Zhang et al., 2019). ...
... [3] However, graphene is easy to agglomerate and stack due to van der Waals forces, which leads to the decrease in specific surface area and even of the specific capacitance of the prepared electrode material. [4] Three-dimensional porous graphene (3D-PG) composed of two-dimensional graphene has a three-dimensional network structure and can reduce the agglomeration of graphene, [5] which exhibits a great specific surface, excellent mechanical strength, [6] ultra-high carrier mobility and ultra-high thermal conductivity. [7] Three-dimensional graphene-based materials usually exhibit four forms that have been previously described in the literature: graphene hydrogel (GH), graphene sponge (GS), graphene aerogel (GA), and graphene foam (GF). ...
... There are various techniques that are used for determination of active components in herbs like HPLC, GC, UHPLC and TLC [96]. Moreover, the recent approaches including hyphenated chromatography and spectroscopy like HPLC-diode array detection (DAD), GC-MS, HPLC-MS, CE-DAD and HPLC-NMR might give additional spectral information which may be helpful for the qualitative and quantitative analysis and even for the structural elucidation [97,98]. With spectral information, the hyphenated instruments show greatly improved performances in terms of the elimination of the instrumental interferences, retention time shift correction, selectivity, chromatographic separation abilities, measurement and precision [97]. ...
... Therefore, it further manifests that there are two protons and two electrons involved in the redox reaction of rutin. The electron transfer rate constant (k s ) is obtained as 4.01 s −1 , which is larger than that of 2.39 s −1 on IL-CPE [29] and 3.4 s −1 on ERGO/GCE [32]. These results suggest that the NF/AuNPs/N-CPDs@FLBP/CILE provides fast electron transfer between the redox groups of rutin and the modified electrode. ...
... PDDA is prepared by cyclic radical polymerization in an aqueous medium in the presence of an initiator, e.g., ammonium persulfate [28]. Graphenefunctionalized PDDA (PDDA-G) has good conductivity, solubility, and biocompatibility, and can be easily decorated with other nanomaterials to impart new properties to the material in order to use it in electrochemical sensors [29][30][31][32][33]. Thus, to determine trace quantities of ferulic acid, a glassy carbon electrode (GCE) modified with PDDA-G, i.e., PDDA-Gr/GCE [29], was used; to determine N-nitrosodiphenylamine, PDDA-G/PtNPs/GCE (where PtNPs are platinum nanoparticles) [30]; to determine puerarin, CdTe-PDDA-G/GCE (where CdTe are quantum dots); to determine dopamine, PDDA-G/AuNPs/GCE (where AuNPs are gold nanoparticles) [31]; to determine allura red, PDDA-G/NiNPs/GCE (where NiNPs are nickel nanoparticles) [32]; and to determine quinoline yellow, PDDA-RGO (where RGO is reduced graphene oxide) [33]. ...
... α, n and K s were calculated as 0.55, 1.57 and 2.86 s −1 , respectively. This result indicated the fast electron-transfer process of SHI on the PEDOT:PSS-β-CD-SWCNT-COOH/GCE.10,19 n was calculated as 1.57, so the number of reactive electrons was about 2. The experimental result showed that the number of electrons and protons was equal in the reaction of SHI on PEDOT:PSS-β-CD-SWCNT-COOH/GCE. Therefore, the redox reaction of SHI on the PEDOT:PSS-β-CD-SWCNT-COOH/GCE surface was two electrons and protons process. ...
... These results are shown in Figure 2A,B, curves c. This significant increase in the MR anode current peak is possibly due to a synergistic effect of graphene that allows for a higher rate of charge transfer [13] and an increase in the MR concentration on the electrode surface, due to increases of the active area surface, which is a very similar effect to that observed in previous reports, where it was used to detect rutin [40,41]. Moreover, when electrodes modified with nanoparticles of metals such as Ni, Zn, and Mo were used, the morin oxidation peak was observed with potential values of less than 0.5 V [10,12,13]. ...