Fabiola Frias's scientific contributions

Publications (8)

Conference Paper
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Introduction: The search for lab innovation in newborn screening is a constant process. The implementation of new markers, the necessity to obtain a robust process, cost effectiveness while minimizing steps, reduce infrastructure adjustments, reduce investments in human resources, keep or improve quality in the results are considered essential poin...
Conference Paper
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Introduction : High numbers of false positives and identification of false negatives suggests adjustment of cut-off values is needed. Many studies about Cystic Fibrosis (CF) and Congenital Adrenal Hyperplasia (CAH) have been published recommending the use of percentiles to correctly classify negative and positives samples, mainly for CF when quanti...
Conference Paper
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Introduction : Newborn Screening for Biotinidase Deficiency has been implemented in the Brazilian Newborn Screening Program (PNTN) since 2012. Since 1999 INTERCIENTIFICA offers the NeoLISA BIO kit using an enzymatic colorimetric method that differentiates the enzyme's activity by the color produced in the end of the reaction. The national legislati...
Conference Paper
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Introduction: The Northeast of Brazil represents 27.7% of population with 9 States and approximately 690.000 newborn screening samples per year. The State of Bahia began to offer newborn screening in 1992. APAE-SALVADOR is the reference institution in the State processing 12.000 samples per month. During the last years, the inclusion of new markers...
Conference Paper
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Introduction: In the last years the organization called Rede DXB, an MSUD workgroup of specialized professionals in Brazil, has produced actions for development of research and diagnosis of MSUD. MSUD is not mandated by the Brazilian Newborn Screening Program but published data reveals an incidence 5 times higher than expected. The Brazilian indust...
Conference Paper
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Introduction: The variation in the incidence of diseases related to newborn screening is an imminent factor for differentiation in the process of implementation of existing programs and priorities. In Brazil, the Ministry of Health has been reinforcing the policy for implementation, in all states of Phase III (Cystic Fibrosis) and the inclusion of...
Conference Paper
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ntroduction: The development of the neonatal screening, with the inclusion of new diseases and larger volumes, triggers the need for a plan to minimize impacts on the quality and processing time. With the concept of reverse innovation, INTERCIENTÍFICA has developed a new fully automated system to meet the needs of different laboratories. Objective:...
Conference Paper
Full-text available
Introduction: The process of continuous improvement of newborn screening programs requires automation and processes that are increasingly safe, accurate, and fast in order to accelerate the release of results of routine samples. In order to meet the demands of continuous improvement, INTERCIENTIFICA developed a fully automated system for the quanti...