FRANÇOIS JACOB's scientific contributions

Citations

... Dynamics and progression of many fundamental processes in cells and organisms, including metabolism [1,2], the cell cycle [3], the circadian clock [4], differentiation [5,6] and development [7] are governed by GRNs. These networks generally control the activity of genes by regulatory motifs such as feedback or feed forward loops [8,9], which ensure spatially and temporally controlled gene expression. A striking property of gene transcription is its distinct stochastic behavior. ...
... Proteins with important functions are usually 'switchable', and their activities are modulated by the binding of other molecules, covalent modifications or mutations outside of their active sites. This transmission of information spatially from one site to another in a protein is termed allostery, which Monod famously referred to as 'the second secret of life' 7,8 . Allosteric regulation is central to nearly all of biology, including signal transduction, transcriptional regulation and metabolic control. ...