F.D. Hileman's research while affiliated with Monsanto Company and other places

Publications (3)

Article
Polychlorinated dibenzofurans (PCDFs) have been synthesized by pyrolysis of individual polychlorobiphenyl cogeners. In certain instances additional PCDFs were formed by either photolysis or chlorination of isolated PCDF congeners. The PCDFs formed by these independent reaction routes were cross correlated with each other to confirm the identity of...
Chapter
A program of safety wiping has been established to monitor the workplace for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans. The procedure uses isooctaine wetted wipes to obtain the samples followed by a simple alumina column cleanup procedure and gas chromatographic-mass spectrometric analysis of the samples. A quality control...

Citations

... The idea was that we should be able to elucidate the role of genes of unknown function by comparing the metabolomes of their deletion mutants with those of the deletion mutants of genes of known function. This concept, often called ''guilt by association'' (Oliver 2000), and a standard strategy in the older 'operational fingerprinting' (Meuzelaar et al. 1982) and the newer machine learning (Goodacre et al. 1998), was to become a prevalent one in functional genomics. In this specific example, the use of metabolomics to reveal similarities between yeast mutants was termed FANCY, for Functional ANalysis by Coresponses in Yeast, by Bas Teusink (Teusink et al. 1998)-an acronym which, for better or worse, never caught on. ...
... Reference mixtures of polychlorinated phenanthrenes, dibenzothiophenes, and thianthrenes were obtained by chlorination of the parent molecules with antimony(V) chloride (SbCl 5 ) in CCl 4 [2,4]. This method was described by Hileman et al. [30]. By varying the reaction time and the amount of SbCl 5 , the degree of chlorination can be controlled. ...