F Libert’s research while affiliated with Université Libre de Bruxelles and other places

... During embryo development, these cells come from different places of blastoderm and develop in different period [12]. As is known, thyroid gland development mainly contains three processes [13]. First, the thyroid anlage appears at a 3-week human embryo. ...

Reference:

Ectopic thyroid tissue in the breast: A case report

... To identify potential conservation between the endostyle and vertebrate tissues, we reanalyzed the published single-cell dataset from zebrafish (Danio rerio) (30,(38)(39)(40). The results indicated that the embryonic lineages of zebrafish, including the pharyngeal endoderm, paraxial mesoderm, neural crest, and pharyngeal arch, exhibited high similarity in expression compared with the endostyle of S. clava (Fig. 1F), suggesting substantial similarity between the ectodermderived tissues from zebrafish and the endostyle. ...

Reference:

Spatially resolved single-cell atlas of ascidian endostyle provides insight into the origin of vertebrate pharyngeal organs

... This process typically takes over 4-6 months, enabling the study of gene function across generations and the longterm effects of gene disruption [35]. On the other hand, transient knockouts, or CRISPants, allow for rapid phenotype observation in injected F0 mosaic embryos, generating biallelic mutations in a high proportion of cells, enabling researchers to detect gene effects within hours or days [59][60][61][62][63][64][65]. ...

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Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish

... Chemokine receptors typically signal via the G αi signaling pathway (Patel et al., 2013). The atypical chemokine receptor 3 (ACKR3), initially described as an orphan receptor (Libert et al, 1990), was discovered to act as second high-affinity receptor for CXCL12, next to CXCR4, and was subsequently renamed to chemokine receptor CXCR7 (Balabanian et al, 2005). Extensive cell signaling and structural biology studies have now provided evidence that ACKR3 does not signal via the canonical G protein pathway of chemokine receptors, but only through -arrestin recruitment , Rajagopal et al., 2010, Kleist et al., 2022, Yen et al., 2022, and therefore belongs to the family of atypical chemokine receptors (Nibbs and Graham, 2013, Sarma et al., Due to the relevance of ACKR3 in cancer and multiple sclerosis (Scholten et al., 2015;Wang et al., 2018, Williams et al., 2014, Torphy et al., 2022, the search for different ACKR3 modulators has so far resulted in a variety of modalities that can target ACKR3, including e.g. ...

Reference:

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3

... Intriguingly, approximately 1% of the human Caucasian population is homozygous for a mutation in the CCR5 gene, consisting of a 32-base pair deletion (CCR5-∆32) that in turn leads to mis-folding of the protein and its subsequent absence from the cell surface. People carrying this mutation are highly resistant to HIV infection [17,18] and fall in the category of Exposed Seronegative Individuals (ESN). ...

Reference:

Investigating the relationship between structural elements of the inner nuclear membrane and HIV infection

... Наши результаты сопоставимы с результатами, полученными в Японии (Narumi S. и соавт. [ [28] путем гибридизации in situ локализовали его до 14q31. Ген содержит 10 экзонов, состоит из α-и β-субъединиц, соединенных дисульфидной связью. ...

Reference:

Pathogenic TSHR variants in children with thyroid dysgenesis

... Hyperosmolarity also leads to neoangiogenesis [6,7]. The retina cannot metabolize this excess lactate, resulting in acidic intracellular pH, synaptic dysfunction, extracellular deposition (drusen), and ultimately apoptosis [8]. Therefore, we suggest that AMD can be viewed as a mitochondrial failure secondary to inflammation and metabolic disease. ...

Reference:

Metabolic Shift and Hyperosmolarity Underlie Age-Related Macular Degeneration

... Während der GTP-Bindung bleibt die Adenylatzyklase aktiviert. Die Adenylatzyklase bildet mehrfach cAMP, das als Botenstoff (second messenger) im weiteren Verlauf eine Proteinkinase aktiviert, welche nun weitere Enzyme phosphoryliert [82]. ...

Reference:

Entwicklung eines Produktionsprozesses für den rekombinanten humanen TSH-Rezeptor

... Among the four adenosine receptors, A 1 AR was the first adenosine receptor identified by pharmacological analysis in 1979 [13] and was cloned from dog in 1991 [14]. A 1 AR is widely expressed in the central nervous system and in peripheral tissue mediating protective effects against brain injury and ischemic kidney injury. ...

Reference:

Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach

... Cloning has allowed the confirmation of the coexistence of both receptors in all the mammalian species studied so far. The first clone isolated was termed the dog RDC4 receptor (40), later identified as the 5-HT 1D receptor (41). Cloning and expression of the two receptors in the human (42-48) revealed a low amino acid similarity between them, with a very similar ligand-binding profile. ...

Reference:

Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain