F A Kallfelz's research while affiliated with Cornell University and other places

Publications (43)

Article
To perform respiratory chain enzymatic activity assays on canine skeletal muscle biopsy specimens and establish reference range values of skeletal muscle enzyme activities for dogs. Biopsy specimens from the vastus lateralis muscle were obtained from 24 dogs (8 sexually intact males and 14 sexually intact females) ranging from 15 months to 6 years...
Article
To determine the effect of dietary protein intake on lean body wasting in adult canines a study was undertaken to investigate the Ubiquitin Proteasome (UP) pathway and concurrent changes in lean and fat body mass of canines fed variable sources and concentrations of dietary protein. Purpose-bred, intact female canines (56) between the ages of 2 and...
Article
Post-exercise carbohydrate supplementation has been routinely used to enhance glycogen concentrations in skeletal muscle, particularly during multiple-day athletic events. Consumption of protein hydrolysates mixed with carbohydrate supplements during the post-exercise period may increase insulin response and cause glycogen repletion in skeletal mus...
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Full-text available
The effects of long-term athletic training are associated with excessive skeletal muscle turnover attributable to increased rates of myofibrillar protein synthesis and proteolysis, which are mechanisms poorly understood in the athletic dog. A physiologic field study using 44 English pointers and Labrador retrievers that had been purposely bred for...
Article
To determine nitrogen balance in clinically normal dogs receiving parenteral nutrition solutions. 8 clinically normal female Beagles. Dogs were randomly assigned to receive 4 treatments in random order. Treatment A consisted of IV administration of nonlactated Ringer's solution. Treatments B, C, and D consisted of IV administration of isocaloric pa...
Article
To determine effects of protein intake on blood variables, plasma volume, and maximal oxygen uptake (VO2max) in sled dogs undergoing rigorous training. 32 Alaskan sled dogs, between 2 and 6 years old. Dogs were assigned to 1 of 4 groups on the basis of age, sex, and ability. Isocaloric diets containing 18% (diet A), 23% (diet B), 29% (diet C), or 3...
Article
To evaluate the effect of immediate postexercise carbohydrate supplementation on muscle glycogen (MG) repletion during the first 4 hours of recovery in sled dogs. 24 Alaskan Huskies. Dogs were assigned to 1 of 3 treatment groups, and a muscle biopsy specimen was obtained 1 hour before and immediately (group A) or 4 hours (groups B and C) after a 30...
Article
Two groups of eight Alaskan huskies fed either a high-fat (HFD; 60% kcal from fat and 15% kcal from carbohydrate) or a high-carbohydrate diet (HCD; 60% kcal from carbohydrate and 15% kcal from fat) performed standard aerobic (1 h at 4 m/s on a 0% slope) and anaerobic (3 min at 6.7 m/s on a 10% slope) tests before and after training. Before and imme...
Article
The medical records of 34 horses with a diagnosis of avulsion of the origin of the suspensory ligament that had been admitted to the veterinary medical teaching hospital between 1980 and 1993 were identified. In addition to clinical examination, 21 of 34 horses had scintigraphy and radiography performed during their examination. The usefulness of s...
Article
The size and quality of muscle specimens obtained by use of a percutaneous biopsy technique were studied. All biopsies were performed under local anesthesia, using an 11-gauge biopsy needle. The mean +/- SEM size of specimens obtained from 128 biopsies of the semitendinosus muscles of 16 Alaskan Huskies was 23.8 +/- 4.4 mg. All biopsy specimens wer...
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Full-text available
Two groups of Alaskan Huskies were fed either a high fat (HFD) or a high carbohydrate diet 4 wk before and during an 8-wk conditioning program. Aerobic bouts of exercise were performed before and after conditioning. Blood samples taken before and after each exercise test were analyzed for serum concentrations of free fatty acids (FFA), triglyceride...
Article
We performed a retrospective study of 100 dogs and 16 cats with planar brain scintigraphy and histopathologically established diagnoses from a total of 485 studies performed from 1976 to 1992. Necropsy (112) or surgical biopsies (4) diagnoses were categorized in two ways: first as focal brain disease, diffuse brain disease or normal; second as eith...
Article
Combined blood pool and delayed images produced by use of 99mTc-methylene diphosphonate (99mTcMDP) were evaluated as an objective measurement of the response of equine joints with osteochondral defects to postoperative exercise and intra-articularly administered polysulfated glycosaminoglycan (PSGAG). Osteochondral defects (approx 2.4 x 0.9 cm) wer...
Article
The objective of this study was to evaluate the effects of a long-term, low-calcium diet on fetal calcium metabolism and fetal skeleton development in ewes. Eleven pregnant sheep were assigned to two groups, fed either a diet low in calcium (0.26% total dry matter) or normal in calcium (0.8% total dry matter) for 2 months, starting at 60 days gesta...
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Full-text available
measured 90-100nm in diameter and enveloped virus par­ticles within membrane-boundcytoplasmic vacuoles,Hepatic adenoviral infection was diagnosed based on thelight and electron microscopic findings, immunocytochem­ical reaction. and viral isolation. Histologically, the consis­tent presenceoflargebasophilicintranuclearinclusion bodiescharacteristic...
Article
The ability of ectopic parathyroid tissue to support calcium homeostasis was evaluated by measuring serum concentrations of calcium, phosphorus, albumin, magnesium, and parathyroid hormone before and for 12 weeks after bilateral thyroparathyroidectomy in 14 cats. During the immediate postoperative period, significant decrease was observed in serum...
Article
Taurine deficiency has been implicated as a potential cause of dilated cardiomyopathy. However, the relationship between taurine and myocardial function is presently unclear. The purpose of this study was to determine whether dilated cardiomyopathy in the fox is associated with dietary taurine deficiency. A total of 68 foxes from farms with a histo...
Article
Ewes were fed ad libitum (up to maximum of 2.5 kg/day) a complete feed containing either 1.52% calcium (High Ca) or 0.59% calcium (Normal Ca) on a dry matter basis from day 50 of pregnancy, and the fetuses were removed at 133-135 days. Thyroid C cells, identified by indirect immunofluorescence, were more numerous (P less than 0.001) and plasma leve...
Article
A 6-year-old Quarter Horse was examined because of acute, severely swollen masseter muscles (palpation of which elicited pain response), exophthalmos, severe chemosis, and protrusion of the third eyelids. Blood selenium and vitamin E concentrations, and results of feed analysis and muscle biopsy supported a diagnosis of nutritional myopathy. The ho...
Article
A case-control study was done to identify factors associated with the development of equine degenerative myeloencephalopathy (EDM). Questionnaires were mailed to the owners of 146 horses admitted to the New York State College of Veterinary Medicine between November 1978 and June 1987 and diagnosed as having EDM by histologic examination. Questionna...
Article
The feasibility of renal arterial infusion of nonbiodegradable microspheres as a model of chronic renal disease in dogs was evaluated. Resin-coated, styrene-divinyl benzene copolymer microspheres were infused into the kidneys of healthy adult Beagles by direct injections of both renal arteries in a single surgical procedure. Injections of 25-micron...
Article
The effects of two local anesthetic agents on the diagnostic quality of nuclear medical bone images (NMBIs) of distal parts of the equine fore limb were investigated. Local effects on bone uptake of technetium 99m methylene diphosphonate (99mTc-MDP) 4 and 24 hours after perineural and intraarticular injection of mepivacaine hydrochloride and bupiva...
Article
Nuclear medical bone imaging was used in combination with targeted radiography to detect metastatic or multicentric lesions in 23 dogs with skeletal neoplasms. Each dog with a radiographically diagnosed skeletal neoplasm was injected with Technetium-99m labeled methylene diphosphonate (99mTc-MDP) (15.0 mCi intravenously) for whole body imaging. All...
Article
This review demonstrates that manufactured pet foods contain more than adequate levels of all the essential nutrients needed by normal dogs and cats. Under normal circumstances, therefore, it is completely unnecessary to supplement the rations of these animals with protein, energy, fatty acids, vitamins, or minerals. We have tried to show that, in...
Article
Questions regarding pet animal nutrition are probably among the most frequent queries encountered by companion animal veterinarians. Given the plethora of pet food products available and the amount of advertising used to promote them, it is not surprising that pet owners have concerns as to what they should feed their pets. This "practical" review...
Article
Serum vitamin E and blood glutathione peroxidase values were determined in 40 horses with a histologically confirmed diagnosis of degenerative myeloencephalopathy and in 49 age-matched control horses with normal neurologic function. Significant differences were not detected in serum vitamin E or blood glutathione peroxidase values between horses af...
Article
Forty veal calves were fed milk replacers containing differing concentrations of Mg in a 16-w study. The concentrations were .1% (basal), .3%, .6% Mg, and .6% Mg plus 2% NaCl. The four groups were further subdivided into two groups fed reconstituted milk replacer at 14 or 17.9% DM. Weight gain was greater at the two lower concentrations of Mg. Calv...
Article
A cerebellar infarction was found to be caused by a vascular thrombosis in a dog. The cause of the thrombosis was not determined. The dog had signs of a central vestibular disturbance. Scintigraphic imaging of the brain revealed evidence of increased uptake of the radionucleotide within the cranial vault. Analysis of CSF revealed albuminocytologic...
Article
The effect of high levels of dietary magnesium (1.4%) alone or in combination with elevated calcium (1.8%) or phosphorus (1.6%) on growth and health of male calves was evaluated during a nine week feeding trial after weaning. Twenty calves were randomly divided into 4 feeding groups consisting of controls, high magnesium, high magnesium and calcium...
Article
Hepatic imaging with 99mTc-sulfur colloid was used to diagnose primary hepatocellular carcinoma (PHC) in woodchucks infected with woodchuck hepatitis virus (WHV). Based on imaging results, 6 of 12 WHV-infected woodchucks had space-occupying hepatic lesions, and all 6 had PHC. Of the remaining woodchucks, 2 did not have PHC, 2 had discrete tumors (l...
Article
The diffusion of glucose (180 M.W.), inulin (5,000 M.W.) and dextran (20,000 M.W.) into mature bovine and equine articular cartilage was studied. Concentration profiles were determined using a one-dimensional experimental configuration and the diffusion coefficient and partition coefficient calculated from a theoretical model. Glucose was found to...
Article
Methyltestosterone (MT) or ethinyl estradiol (EE) was administered to adult rabbits for 20 weeks beginning with initial daily doses of 0.4 mg/kg MT and 0.015 mg/kg EE for three weeks, then these dosages were doubled at 3-week intervals to a maximum dosages 6.4 mg/kg and 0.24 mg/kg, respectively. Within 2 weeks, the serum gamma-glutamyltransferase a...
Article
Radionuclide joint imaging has been adapted for use in the diagnosis of canine hip dysplasia. Studies were done on 29 growing Labrador Retriever pups between 3 months and 1.5 years of age and on two adult dogs. Initally, pelvic radiographs and joint images were done on pups 12 to 16 weeks of age and were repeated at 2-week intervals thereafter. 99m...
Article
The value of brain imaging or scintigraphy for the diagnosis of intracranial soft tissue lesions in dogs and cats was investigated. During the course of the study, 2 radiopharmaceuticals, 3 imaging instruments, and various positions were investigated to determine the best protocol. Twenty-one cases of suspected intracranial disease with normal radi...
Article
Esophageal patch grafting, using the sternocephalicus muscle, was used for treatment of cervical esophageal stricture in a mare. The mare was maintained during the initial healing phase by total parenteral nutrition.
Article
The effects of experimentally induced joint disease were serially observed by means of radionuclide joint scanning and radiographic examination in five Labrador retriever dogs. Within two weeks of experimental induction of degenerative hip joint disease, radionuclide scans were abnormal and showed asymmetrical increased uptake of radiopharmaceutica...

Citations

... Although the aetiology of urolithiasis is complex and multifactorial, dietary factors have been suggested to be important (Gasthuys et al., 1993). Previously, high levels of dietary magnesium have been reported to result in an increased incidence of urolithiasis and urethral obstruction in cats (Kallfelz et al., 1980). Kallfelz and colleagues (1987) also concluded that feeding rations containing high levels of magnesium (1.4%) resulted in an increased incidence of urolithiasis and urinary tract obstruction in growing male calves. ...
... There are a few conventional radiopharmaceuticals for planar brain scintigraphy: 99m Technecium labelled diethylenetriaminepentaacetic acid ( 99m Tc DTPA), glucoheptonate ( 99m Tc GH), or 99m Technecium-pertechnetate ( 99m TcO 4 -) which are available for veterinary purposes as well Dykes et al. 1994). Because of their higher prices 99m Technecium hexamethylpropyleneamine oxime ( 99m Tc HM-PAO) and ethylcysteinate dimer ( 99m Tc ECD) are less frequently used substances in veterinary practice; however, both are very promising agents when brain SPECT examination is considered. ...
... It is possible to use it in horses with stricture type 3 (Craig et al. 1989, Stick 2006. Esophagoplasty, esophageal replacement and mucosal patch grafting have been used in horses in individual cases with limited success (Hoffer et al. 1977, Craig et al. 1989). Fenestration through a cicatrix can be used in a horse with esophageal stricture. ...
... Endocrine neoplasms were reported in two felids, a thyroid carcinoma in an 18-year-old female tiger and a thyroid adenoma in an 18-year-old male leopard. Thyroid tumors are commonly diagnosed in captive felids and have been previously reported in several studies (9,11,15,(30)(31)(32). This low rate of endocrine tumors is, in fact, in contrast with previous studies (9,30). ...
... glândulas paratireóides externa e interna do lado contralateral mantém a normocalcemia. A presença de somente uma glândula paratireóide pode manter os níveis séricos de cálcio normais [2,9,15]. Em dez animais submetidos a paratireoidectomia com implantação da glândula paratireóide em etapas [15], ou seja, com pelo menos um mês de diferença entre as cirurgias, não houve o desenvolvimento de hipocalcemia clínica após a segunda cirurgia, provavelmente pela neovascularação da glândula paratireóide implantada na primeira cirurgia que ocorre em torno de duas semanas [16]. ...
... Taurine increases myocardial contractility, possibly through modulation of calcium movement and availability for excitation-contraction coupling. Taurine's role in DCM has been well studied by veterinary medicine, and diet supplementation is a common treatment for DCM in domestic mammals [10][11][12][13][14] . It is unknown whether taurine supplementation can improve human DCM, and furthermore whether improvements are observed when taurine levels are in normal reference ranges. ...
... Vitamin E/Selenium deficiency causes the following syndromes in horses: acute and sub-acute forms of enzootic nutritional muscular dystrophy (NMD), equine degenerative myeloencephalopathy and equine motor disease. Enzootic nutritional muscular dystrophy occurs commonly in foals of about 7 months, born by mares fed for long periods on diets low in vitamin E and Selenium (Step et al., 1991). Dystrophic myodegeneration has been reported in adult horses (5-10 years) having vitamin E/Selenium deficiency (Step et al., 1991). ...
... Rapid growth has been described as one of the main contributing factors predisposing to the development of osteochondrosis (Ekman & Carlson 1998;Reiland 1977). Osteochondrosis has been described in pigs (Grøndalen 1974), dogs (Trostel, McLaughlin & Pool 2002), newborn lambs (Corbellini et al. 1991), poultry (Whitehead 1997), turkeys (Poulos 1977), horses (Jeffcott 1991), cattle (Trostle et al. 1998), cats (Ralphs 2005) and rats (Kato & Onodera 1984). ...
... This hypothesis is further supported clinically, because eNAD/EDM can be prevented, or at least minimized, by supplementing pregnant mares and genetically susceptible foals with α-TOH. 1,2,28 Studies in humans have used serum and plasma to measure vitamers and metabolites. [29][30][31] However, our previous study reported that quantification differs between equine serum and plasma and should be accounted for when setting reference ranges. ...
... Bone survey radiographs, including lateral views of all bones in the body and a ventrodorsal projection of the pelvis, have been useful in detecting second skeletal sites of OSA [34]. Whereas whole-body bone scans are standard in human medicine, there are conflicting reports on the utility of nuclear scintigraphy for clinical staging of dogs with OSA [35][36][37][38][39]. It can be useful for detection and localization of bone metastasis in dogs presenting for vague lameness or signs of back pain. ...