July 1988
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10 Reads
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1 Citation
Middle East journal of anaesthesiology
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Publications (25)
July 1988
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4 Reads
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1 Citation
Middle East journal of anaesthesiology
May 1988
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8 Reads
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30 Citations
BJA British Journal of Anaesthesia
A 21-year old female in active labor was given 1 mg of preservative-free morphine in 10% dextrose solution intrathecally when pain relief was requested. Pain relief was evaluated on a visual analog scale and note made of cardiorespiratory variables including ventilatory rate, degree of alertness and arterial oxygen saturation. Partial analgesia started 30 minutes after drug injection but the pain never showed marked relief, prompting the administration of 8 ml of 0.5% bupivacaine extradurally with complete pain relief. An infant was delivered vaginally without problems nearly 7 hours after intrathecal morphine. 8 1/2 hours after intrathecal injection she required 3 doses of 0.1 mg of naloxone IV for control of vomiting despite which she remained sleepy, had episodes of unconsciousness, and demonstrated decreased SaO2 (92%). Over the next 6 hours she received a total of 3.2 mg of naloxone by bolus and drip to produce improvement of ventilation and consciousness as well as normalization of SaO2.
April 1988
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8 Reads
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33 Citations
BJA British Journal of Anaesthesia
The intrathecal administration of hyperbaric morphine 1 mg for pain relief during labour was followed, 7 h after injection, and 1 h after delivery, by respiratory depression. Pulseoximetry was helpful in alerting the medical personnel. After an initial 1 mg of naloxone i.v. in increments of 0.1–0.2 mg, a continuous infusion of naloxone 0.4 mg h−1 i. v. was used to prevent a recurrence of the respiratory depression. The total dose of naloxone over an 8-h period was 3.6 mg.
December 1987
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13 Reads
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9 Citations
BJA British Journal of Anaesthesia
October 1982
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11 Reads
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14 Citations
Survey of Anesthesiology
March 1982
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3 Reads
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1 Citation
Obstetric Anesthesia Digest
December 1981
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16 Reads
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6 Citations
Anesthesiology
December 1981
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4 Reads
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5 Citations
Survey of Anesthesiology
November 1981
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59 Reads
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40 Citations
BJA British Journal of Anaesthesia
In a double-blind study, seven Macaca fascicularis monkeys receiving intrathecal (i.t.) morphine in saline, 0.07 mgkg−1, were compared with a control group of four monkeys receiving either lumbar puncture alone (n = 1) or i.t. saline (n = 3). Neither morphine nor saline solutions contained preservatives. Arterial blood gas tensions, respiration, arterial pressure, e.c.g., state of consciousness and motor function were recorded for 24 h. The control group was sacrificed 42 days later and the study group was sacrificed at 6 (n = 2) or 42 days (n = 5) after injection. The central nervous system, meninges, nerve roots and dorsal root ganglia were examined macroscopically and microscopically. Respiratory depression did not occur in either the control or the study groups. There were moderate but statistically significant decreases in systolic and diastolic arterial pressures following i.t. morphine. In both groups, the pathological findings were localized to the cauda equina region and characterized by mononuclear cell infiltration. In neither group was there evidence of demyelination, arachnoiditis or necrosis. Focal endoneurial fibrosis was found in only one animal in the control group following multiple lumbar punctures associated with paraesthesia. The features appeared to correlate with the physical trauma associated with lumbar puncture rather than with the injectate.
Citations (19)
... Although EBP has been utilized in the field of healthcare for more than 40 years [23], its inconsistent effectiveness has remained a challenge for medical practitioners. Previous studies have reported that Blinded EBP has a first-time effectiveness rate of 36 − 52%, compared to 58.7 − 87.1% for targeted [17,[24][25][26]. ...
- Citing Article
June 1976
Survey of Anesthesiology
... mg/kg, the dose that is clinically used but was effective in 6 this dose in combination with bu pivacaine [7]. It had been suggested that this effect is related to interaction with membranes [8,9]. Some strains are resistant, as P. aeruginosa is resistant to lidocaine and procaine [10] and also bupivacaine. ...
- Citing Article
December 1981
Survey of Anesthesiology
... Bien que le sang soit rapidement résorbé (dès trois heures après la réalisation du BP), le clou plaquettaire reste présent au moins sept jours après [2,6]. En 1975, Abouleish E. et al [7] ont publié une étude au cours de laquelle ils ont mentionné que la réalisation d'une anesthésie péridurale ou rachidienne chez deux patientes ayant bénéficié d'un blood patch moins de 380 jours auparavant, n'avaient présenté aucun problème. ...
- Citing Article
August 1976
Survey of Anesthesiology
... In a study of monkeys, focal endoneurial fibrosis was associated with multiple lumbar punctures and paresthesia (11). In our study, histopathological changes may have been due to trauma caused by the catheter, but none of the patients was symptomatic. ...
- Citing Article
October 1982
Survey of Anesthesiology
... These side effects are caused by the drug gaining access to the spinal cord and brain stem from the cerebrospinal fluid. 20,21 Hence, intrathecal morphine requires appropriate postoperative care. ...
- Citing Article
April 1988
BJA British Journal of Anaesthesia
... Moreover, it had been applied for the determination of barium and sulfate using novel barium polymeric membrane sensor [25]. Conductometric methods had been also reported for clindamycin HCl and macrolide antibiotics [22,26] in addition to fl uorometric quantitation of pancuronium bromide in human serum [27]. ...
- Citing Article
July 1979
Journal of Pharmaceutical Sciences
... 32 For patients with PDPH refractory to conservative therapies, an epidural blood patch (EBP) may provide immediate relief and has success rates between 65-98%. 31,[33][34][35][36][37] EBP is performed by injecting the patient's own blood through a needle into the epidural space. The mechanism of action by which EBP relieves PDPH is unclear, but it is thought that the injection of blood compresses the thecal sac, increasing lumbar and intracranial CSF pressure. ...
- Citing Article
July 1975
Anesthesia & Analgesia
... 14 In fact, the first interpretation in the literature was brought up by Abouleish and Amortegui in 1977 with the claims whether bacteria filters are necessary in epidural anaesthesia which is especially used for labour. 15 In the following years, the fact that there were various numbers in the frequency of complications such as bacterial meningitis and epidural abscess in long-term epidural catheterisation caused a number of researchers and clinicians to be unclear about this issue. 16---21 This study is also crucial for having a rough idea whether bacteria filters should be administered in short-term (48 h) labour analgesia practically and scientifically. ...
- Citing Article
June 1977
Anesthesiology
... Some authors reported that caudal anaesthesia was a useful technique for minor anal surgery. (10,11) Abouleish also stated that caudal epidural block was used safely as a labouring analgesia (12) .In Taiwan, Chen et al (13) first reported the use of caudal block during a vaginal delivery. But our study was mainly confined to minor gynaecological operations in perineal area which only require anaesthesia in lumbosacral area which may be done by local anaesthesia alone. ...
- Citing Article
January 1976
Anesthesia & Analgesia
... The patients were asked: "What was the last thing you remember before going to sleep?" What was the first thing you remember when you woke up?" Can you recall anything between?" and "Did you have any dreams during your anesthetic?" [16,17]. Apgar scores of the newborn infants were measured at 1, 5 and 20 min after delivery. ...
- Citing Article
September 1976
Anesthesia & Analgesia