Eyituoyo Okoturo's research while affiliated with Lagos University Teaching Hospital and other places

... Although multiple molecular markers has been studied including, viral markers (E6, E7), cellular markers (Ki67/ MIB-1, MYC, Survivin), nucleic acid changes (DNA methylation, miRNAs) their usage in population based screening are limited.Many studies have evaluated p16 as a surrogate marker for HR -HPV infection using IHC (Duncan et al., 2013;Gronhoj Larsen et al., 2014). p16 / Ki-67 dual immunostaining has been reported as better approach for cervical cancer screening compared to conventional methods (Eyituoyo Okoturo, 2023). Some of the drawbacks in using p16 IHC are (i) need for trained cytologists / pathologists. ...

... In the civilian setting, because no training is required to collect saliva, this sample source could be collected at home and then dropped off at a drive-thru for actual testing. Importantly, studies have validated that SARS-COV-2 is detectable in saliva [9][10][11][12][13][14]. ...

... 12 HNC patients in Africa may be at greater risk of recurrence and poor survival due to limited diagnostics and treatment options. 13 Further to these factors, HNC patients in Africa are more likely to suffer from socioeconomic deprivation, greater levels of poverty, and worse sociocultural factors such as poorer levels of education. 14 Consistent prevalence estimates from Africa are crucial to understanding the burden of local recurrence and survival after treatment of patients in this region and highlighting the necessity for clinical attention. ...

... However, shortages of trained support staff including nurses and anesthetists in LMIC impede early detection of flap compromise, and even after compromise is detected, further delays in the assembly of the operating team adversely impact the overall results of salvage procedures. 13,51,73 Unfortunately, inadequate reporting of factors relating to flap failure and complications prevented detailed analysis in this study. Nevertheless, the binary logistic regression result showing no association between the different free flaps, each with their own technical perils and free flap success suggests more systematic causes for flap failure that warrant further study. ...

... 8 Our group has published the most comprehensive catalog of susceptible genes and polymorphisms in African population-based cancers with limited reports on HNSCC candidate alleles. 9 While there are several reports on HNSCC candidate genes, 10,11 there remains no catalog of candidate genes for African population-based HNSCC. Reviewing genetic polymorphisms in HNSCC in African populations will appraise the current evidence and gene distinction from the known HNSCC candidate genes. ...

... LASUTH is one of the two teaching hospitals in Lagos that provide medical and dental care to the citizens of Lagos State. 22 It is also a referral Centre for private and public health institutions for other neighboring states. ...

... The evaluation referred among others to the range of mouth opening, chewing, swallowing, speech quality, speech understanding and tongue mobility. In most instances, function control is based on subjective patients' assessment using standardized scales and questionnaires such as the Functional Intraoral Glasgow Scale, Head and Neck Performance Status Scale, University of Washington Quality-of-Life, Oral Health Impact Profile, Eating Ability Evaluation Questionnaire, or 14-item Oral Health Impact Profile Questionnaire [15][16][17][18][19][20]. Methods of objective function assessment, such as measurements of the range of mouth opening or measurements of bite strength, appeared much less frequently in research [21][22][23]. ...

... In contrast, developing healthcare systems like ours in Nigeria frequently use nonvascularized bone grafts, capitalizing on the high incidence of benign mandibular lesions in children [26][27][28]31]. A third treatment option, periosteum-mediated bone regeneration (PMBR) of the mandible, is commonly used in developing healthcare systems and is gradually gaining acceptance at Western centers [32,33]. To date, 32 case series involving 63 cases have been reported , with 44% (28/63) of these cases originating from Africa [33,34,41,50,52,54,55,57]. This trend may be due to limited facilities that hinder immediate or vascularized reconstruction. ...

... The parotid is located in the parotid space and can be affected by a variety of pathological processes, especially tumors. [2,3] Both benign and malignant tumors can arise from the parotid gland, but benign tumors are more common compared to their malignant counterparts. [1] Benign tumors include pleomorphic adenoma, Warthin's tumor, basal cell adenoma, canalicular adenoma, and myoepithelioma, with pleomorphic adenoma as the most common, whereas the malignant tumors include but are not limited to adenoid cystic carcinoma, mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma. ...

... These findings were basically consistent with data from other studies. 9,11 This study collected data on 4 different types of jaw malignancies with similar clinical manifestations and treatment methods, but after specific analysis we found that they have some different characteristics and prognoses. First, the most common malignant tumor in the jaw was SCC, which accounted for 56.3% of all tumors in this study. ...