Ethan Wantman's research while affiliated with New York Institute of Technology and other places

Publications (62)

Article
As the proportion of births conceived with assisted reproductive technology (ART) continues to increase, a growing body of literature continues to examine the risks involved such as the higher risk of birth defects. Recently, several studies have suggested that ART-conceived children may have a greater risk of childhood cancer. This population-base...
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Background: Fertility preservation (FP) may be underused after cancer diagnosis because of uncertainty around delays to cancer treatment and subsequent reproductive success. Methods: Women aged 15 to 39 years diagnosed with cancer between 2004 and 2015 were identified from the North Carolina Central Cancer Registry. Use of assisted reproductive...
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STUDY QUESTION Is there an association between fertility status, method of conception and the risks of birth defects and childhood cancer? SUMMARY ANSWER The risk of childhood cancer had two independent components: (i) method of conception and (ii) presence, type and number of birth defects. WHAT IS KNOWN ALREADY The rarity of the co-occurrence o...
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Purpose Women face multiple barriers to fertility preservation after cancer diagnosis, but few studies have examined disparities in use of these services. Methods Women aged 15–39 years diagnosed with cancer during 2004–2015 were identified from the North Carolina Central Cancer Registry and linked to the Society for Assisted Reproductive Technolo...
Article
Objective To develop in vitro fertilization (IVF) prediction models to estimate the individualized chance of cumulative live birth at two time points: pretreatment (i.e., before starting the first complete cycle of IVF) and posttreatment (i.e., before starting the second complete cycle of IVF in those couples whose first complete cycle was unsucces...
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PurposeTo compare academic achievement in reading and mathematics at the end of sixth grade and progress from third to sixth grade by children conceived with in vitro fertilization (IVF) to those conceived naturally.Methods This was a retrospective population-based cohort study of IVF-conceived singleton and twin children who took the 3rd grade and...
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Purpose Excess embryos transferred (ET) (> plurality at birth) and fetal heartbeats (FHB) at 6 weeks’ gestation are associated with reductions in birthweight and gestation, but prior studies have been limited by small sample sizes and limited IVF data. This analysis evaluated associations between excess ET, excess FHB, and adverse perinatal outcome...
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Context Antimullerian hormone (AMH) level is strongly associated with ovarian response in reproductive technology (ART) cycles but is a poor predictor of live birth. It is unknown whether AMH is associated with cumulative live birth rates (CLBR) in women with diminished ovarian reserve (DOR). Objective To examine the association between serum AMH...
Article
Background: In the United States (U.S.), >45,000 adolescent and young adult (AYA) women are diagnosed with cancer annually. Reproductive issues are critically important to AYA cancer survivors, but insufficient information is available to address their concerns. The AYA Horizon Study was initiated to contribute high-quality, contemporary evidence...
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Purpose To investigate whether live birth rates from euploid blastocyst frozen-thawed embryo transfer (FET) cycles are associated with infertility diagnosis or oocyte source. Design Retrospective analysis of FET cycles reported to SART CORS in 2014. Methods Data from fresh IVF cycles with preimplantation genetic testing for aneuploidy (PGT-A), li...
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STUDY QUESTION What is the association between ART conception and treatment parameters and the risk of birth defects? SUMMARY ANSWER Compared to naturally conceived singleton infants, the risk of a major nonchromosomal defect among ART singletons conceived with autologous oocytes and fresh embryos without use of ICSI was increased by 18%, with inc...
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Abstract Background Numerous studies have demonstrated substantial differences in assisted reproductive technology outcomes between black non-Hispanic and white non-Hispanic women. We sought to determine if disparities in assisted reproductive technology outcomes between cycles from black non-Hispanic and white non-Hispanic women have changed and t...
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Importance: Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF). Objective: To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturall...
Article
Objective To evaluate if there are differences in standardized testing results at the end of third grade between children conceived with the use of in vitro fertilization (IVF) and those conceived spontaneously. Design Retrospective population-based cohort. Setting Texas public school system. Patient(s) Singleton and twin children 8–9 years of a...
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Importance In vitro fertilization (IVF) is associated with birth defects and imprinting disorders. Because these conditions are associated with an increased risk of childhood cancer, many of which originate in utero, descriptions of cancers among children conceived via IVF are imperative. Objective To compare the incidence of childhood cancers amo...
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Purpose To evaluate the risk of prematurity and infant mortality by maternal fertility status, and for in vitro fertilization (IVF) pregnancies, by oocyte source and embryo state combinations. Methods Women in 14 States who had IVF-conceived live births during 2004–13 were linked to their infant’s birth and death certificates; a 10:1 sample of non...
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Objective To assess the attitudes of Society for Assisted Reproductive Technology (SART) members regarding expanding insurance coverage for patients seeking assisted reproductive technologies (ART) and identify some of the factors that may influence such attitudes. Design An anonymous online 14-question survey of SART membership; 1,556 surveys wer...
Article
Background: Over the past 2 decades the characteristics of women giving birth in the United States and the nature of the births themselves have changed dramatically, with increases in older maternal age, plural births, cesarean deliveries, and conception from infertility treatment. Objective: We sought to evaluate the risk of severe maternal mor...
Article
Objective: To determine if serum antimüllerian hormone (AMH) is associated with and/or predictive of live birth assisted reproductive technology (ART) outcomes. Design: Retrospective analysis of Society for Assisted Reproductive Technology Clinic Outcome Reporting System database from 2012 to 2013. Setting: Not applicable. Patient(s): A tota...
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Background Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pa...
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The Society for Assisted Reproductive Technology (SART) was established within a few years of assisted reproductive technology (ART) in the United States, and has not only reported on the evolution of infertility care, but also guided it toward improved success and safety. Moving beyond its initial role as a registry, SART has expanded its role to...
Article
Objective: To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. Design: Retrospective analysis. Setting: Not applicable. Patient(s): 5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ultralow AMH values. In...
Article
To use a validated prediction model to examine whether single embryo transfer (SET) over two cycles results in live birth rates (LBR) comparable to two embryos transferred (DET) in one cycle, while reducing the probability of a multiple birth (i.e., multiple birth rate, MBR). Prediction models of LBR and MBR for a woman considering ART developed fr...
Article
Objective: To develop a model predictive of live-birth rates (LBR) and multiple birth rates (MBR) for an individual considering assisted reproduction technology (ART) using linked cycles from Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) for 2004-2011. Design: Longitudinal cohort. Setting: Clinic-base...
Article
To evaluate factors associated with monozygosity (MZ) (number of fetal heartbeats on early ultrasound greater than the number of embryos transferred) and the risk of recurrence in subsequent pregnancies using a national assisted reproduction database. Historical cohort study. Clinic-based data. 197,327 pregnancies (including 2,824 with evidence of...
Article
Objective To evaluate the effect of a prior assisted reproductive technology (ART) live birth on subsequent live-birth rates. Design Historical cohort study. Setting Clinic-based data. Patient(s) The study population included 297,635 women with 549,278 cycles from 2004 to 2010 from the Society for Assisted Reproductive Technology Clinic Outcome...
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Article
This study uses linked cycles of assisted reproductive technology (ART) to examine cumulative live birth rates, birthweight, and length of gestation by diagnostic category. We studied 145,660 women with 235,985 ART cycles reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System during 2004-2010. ART cycles were...
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Live-birth rates after treatment with assisted reproductive technology have traditionally been reported on a per-cycle basis. For women receiving continued treatment, cumulative success rates are a more important measure. We linked data from cycles of assisted reproductive technology in the Society for Assisted Reproductive Technology Clinic Outcom...
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To comprehensively report Society for Assisted Reproductive Technology (SART) member program usage of preimplantation genetic testing (PGT), preimplantation genetic diagnosis (PGD) for diagnosis of specific conditions, and preimplantation genetic screening for aneuploidy (PGS). Retrospective study. United States SART cohort data. Women undergoing a...
Article
To determine whether the first cycle of assisted reproductive technology (ART) predicts treatment course and outcome. Retrospective study of linked cycles. Society for Assisted Reproductive Technology Clinic Outcome Reporting System database. A total of 6,352 ART patients residing or treated in Massachusetts with first treatment cycle in 2004-2005...
Article
To determine the feasibility of linking assisted reproductive technology (ART) cycles for individual women to compare per-cycle and cumulative live-birth rates. Historical cohort study. Clinic-based data. A total of 27,906 ART cycles with residency or treatment in Massachusetts during 2004-2006 and reported to the Society for Assisted Reproductive...

Citations

... However, few studies with a limited number of patients show an increase in glucose intolerance and hypertension in ART-generated offspring [173][174][175][176]. These data together with the slight increase in obstetrical and perinatal complications, as well as congenital defects observed in ART-generated offspring [176][177][178][179][180], warrant caution. It is of paramount importance to continue followup of the health of IVF-conceived offspring to clarify possible adverse outcomes not only at the delivery but also later in life, during childhood or adulthood. ...
... The most established method of fertility preservation, embryo cryopreservation, costs approximately $12,000 per cycle and is not routinely covered by health insurance [5]. It has been documented that women with cancer were less likely to utilize fertility preservation procedures if they were of lower socioeconomic position [6]. The state of Michigan does not have a state mandate requiring insurers to offer coverage for infertility treatments or assisted reproductive technologies. ...
... Propensity scores were generated using a logistic regression model to estimate the predicted probability of receiving r-hFSH:r-hLH or r-hFSH alone, as a function of the variables recorded by D·I·R centres. For this study, the covariates included in the statistical models were chosen by the clinician co-authors, based on variables that have been reported/validated to predict either live birth or cumulative live birth after OS for ART treatment (Leijdekkers et al. 2018, Ratna et al. 2020, McLernon et al. 2022) and on data that were routinely available in the D·I·R database. ...
... As observed, a large percentage of the patients who answered the questionnaire identified themselves as white, showing the racial disparity in access to assisted reproduction treatments [29,30]. According to Butts (2021), black patients begin the search for infertility research 6 to 15 months after white patients do, and they still take a longer time to perform adequate treatment, which negatively reflects on ovarian reserve, leading them to undergo more cycles of treatment with greater costs and lesser successes, characterizing racial inequalities and the absence of equal access to treatments [31]. ...
... Intelligence in the young adolescent age group was measured from school subject's test scores [43][44][45][46]. ART students scored significantly higher than NC students in reading or language (only from native language score) (p = 0.00001), although significant heterogeneity was acknowledged (I 2 = 94%, p = 0.00001) (Fig. 8A). ...
... The Horizon Study is a cohort of assigned female at birth, primarily cisgender females diagnosed with cancer as AYAs [7]. Eligible participants were 18 years of age or older at survey, assigned female at birth, diagnosed with cancer as an AYA (ages 15-39 years) during 2004-2016 with 1 of the 5 most common cancers in this age group among cisgender women: breast, thyroid, melanoma, gynecologic, or lymphoma [8]. ...
... In the US, the SET rate was 74.1% in 2018 (9), and recent data from the Society of Assisted Reproductive Technology suggest that the use of SET has further increased (78.4% of ART in 2020) (31). Indeed, compared with multiple embryo transfers, neonatal outcomes with SET are improved and include a reduction in the incidence of prematurity (32,33). Although we are unable to ascertain the use of SET in the Center for Disease Control and Prevention database, it seems likely it follows the trend described elsewhere. ...
... Likewise, pregnancies resulting from ART have been historically associated with an increased risk of preterm delivery in singleton pregnancies [7,8] and low birth weight [9,10] compared to pregnancies conceived naturally. A large population-based cohort study comparing births between 2004 and 2016 in the United States [11] found that singleton infants born from infertility treatments using autologous oocytes (78,362 cases) had a higher risk of non-chromosomal defects, cardiovascular and musculoskeletal defects, and major defects than naturally conceived children (1,037,757 cases). Moreover, this risk is increased with treatments involving the ICSI technique, and more so with male infertility (18%, 30%, and 42%, respectively). ...
... A largely unexplored potential explanation for the overlap between nonchromosomal birth defects and leukemia, as well as other pediatric cancers, is the role of nongenetic in utero factors and exposures that could lead to both phenotypes (eg, maternal diabetes) or postnatal exposures that children with birth defects are more likely to receive (eg, diagnostic procedures that involve radiation). 21 However, outside of a recent assessment evaluating the impact of in vitro fertilization (IVF) on the co-occurrence of birth defects and pediatric cancer, which reported that IVF-exposed children were more likely to develop both birth defects and cancer compared to naturally conceived children, 45 there have been few attempts to evaluate the role of various exposures on the overlap between these conditions. ...
... The majority of these examined negative outcomes following MAR such as in vitro fertilization, intrauterine insemination, and intracytoplasmic sperm injection, among others. Low live birth rates following MAR were found in Black [6,34,40,46,50,51,61,63,65,69,73,76,77,88,90], Asian [6,40,50,51,61,63,69,73,77], Hispanic [6,34,51,57], and Middle Eastern/North African women [75]. Low intrauterine/clinical pregnancy rates were seen in Black [6,51,65,69,85,88], Asian [6,51,65,69,85,88], Hispanic [6,51,69], and American Indian/Alaska Native [33] women. ...