January 2024
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In this study, p(CTP‐co‐MMCA) microparticles, a novel cyclomatrix polyphosphazene, were synthesized. Among the p(CTP‐co‐MMCA) polymeric structures, p(CTP‐co‐MMCA) (1 : 3) with a high surface amine group was found to be in the form of microparticles after detailed structural and morphological characterization. These microparticles were modified with Au⁰ and Ag⁰ nanoparticles using two different green reductants. The antimicrobial activities of p(CTP‐co‐MMCA) microparticles and their Au⁰ and Ag⁰ composites against P.Aeruginosa ATCC 27853, S.Aureus ATCC 6538 and C.Albicans were investigated. Metal composites were found to have better antimicrobial activity. Cyclomatrix p(CTP‐co‐MMCA) microparticles with antimicrobial properties and their Au⁰ and Ag⁰ composites were also used for the release of Ceftriaxone sodium and RNA. Cyclomatrix p(CTP‐co‐MMCA) microparticles and its Au⁰ and Ag⁰ composites retained 48.21±5.34 mg/g, 49.36±6.95 mg/g and 23.95±6.45 mg/g ceftriaxone sodium, respectively, while they retained 79.15±6.85 mg/g, 47.49±6.24 mg/g and 57.47±9.48 mg/g RNA, respectively. Release studies revealed that the presence of Au⁰ and Ag⁰ nanoparticles imparted a slower release behavior to p(CTP‐co‐MMCA) microparticles. The release studies revealed that the presence of Au⁰ and Ag⁰ nanoparticles imparted a slower release behavior to the p(CTP‐co‐MMCA) microparticles.