Erin J Cram’s research while affiliated with Northeastern University and other places

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Publications (2)

Figure 1. Exopher production by stressed neurons in C. elegans. (A) In the C. elegans hermaphrodite worm, the reproductive system consists of two gonad arms, which contain the germline, and a common uterus (indicated by the blue box), where eggs accumulate before they are laid. The cell body of a lateral microtubule neuron (red circle) is in close proximity to the uterus, and the neurite of this neuron (red line) extends all the way to the head of the worm. (B) When only a small number of eggs are in the uterus, the neuron does not produce exophers. (C) However, when eggs accumulate in the uterus, the cell body becomes stressed and exophers (small red circles) are released.
Mechanosensory neurons under pressure
  • Article
  • Full-text available

March 2024

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28 Reads

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1 Citation

eLife

Erin Cram

A build-up of eggs in the uterus of the nematode C. elegans triggers the release of large extracellular vesicles, called exophers, from neurons that are sensitive to mechanical forces.

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Exophers to feed them all

July 2021

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11 Reads

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4 Citations

EMBO Reports

Erin J Cram

Cells release extracellular vesicles to remove damaged components and communicate with other cells via packets of proteins, lipids, and RNAs. Neuronal cells in the nematode C. elegans release particularly large extracellular vesicles, known as exophers, to rid themselves of damaged organelles and protein aggregates. Turek et al now demonstrate a new role for these vesicles: Embryos in the uterus stimulate body wall muscle cells to release exophers laden with yolk, which are taken up by oocytes to nourish the next set of embryos (Turek et al, 2021).

Citations (1)

... They are large membrane-bound vesicles distinct from exosomes or apoptotic bodies since they are produced independently of the ESCRT machinery and do not have phosphatidylserine on their surface. The production of exophers increases in proteostasis-impairing conditions and with the suppression of autophagy or protein turnover [84][85][86][87]. Large oncosomes are micrometre-sized cancer cell-derived large EVs that originate from the plasma membrane of amoeboid cancer cells [88]. ...

Reference:

Unravelling the Role of Cancer Cell-Derived Extracellular Vesicles in Muscle Atrophy, Lipolysis, and Cancer-Associated Cachexia
Exophers to feed them all
  • Citing Article

  • July 2021

EMBO Reports

Erin J Cram