Erin D. Bigler's research while affiliated with University of Utah and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (675)
Objective:
This prospective, longitudinal cohort study examined the trajectory, classification, and features of posttraumatic headache after pediatric mild traumatic brain injury.
Methods:
Children (N = 213; ages 8.00 to 16.99 years) were recruited from two pediatric emergency departments <24 hours of sustaining a mild traumatic brain injury or...
Introduction:
Concussion in children and adolescents is a public health concern with higher concussion incidence than adults and increased susceptibility to axonal injury. The corpus callosum is a vulnerable location of concussion-related white matter damage that can be associated with short- and long-term effects of concussion. Interhemispheric t...
The objectives of this machine-learning (ML) resting-state magnetoencephalography (rs-MEG) study involving children with mild traumatic brain injury (mTBI) and orthopedic injury (OI) controls were to define a neural injury signature of mTBI and to delineate the pattern/s of neural injury that determine behavioral recovery. Children aged 8-15 years...
While traditionally ignored as a region purely responsible for motor function, the cerebellum is increasingly being appreciated for its contributions to higher-order functions through cerebro-cerebellar networks. Traumatic brain injury (TBI) research generally focuses on the cerebrum, in part because of the frequency of acute pathology. Acute patho...
Background
Prior studies have shown poor recruitment and retention of minoritized groups in clinical trials.Objective
To examine several social determinants as predictors of consent to participate and retention as part of a prospective, longitudinal cohort study of children 8–16 with either mild traumatic brain injury (mild TBI) or orthopedic injur...
Objective:
To investigate the factors predictive of novel psychiatric disorders in the interval 0-6 months following traumatic brain injury (TBI).
Methods:
Children ages 5-14 years consecutively hospitalized for mild to severe TBI at five hospitals were recruited. Participants were evaluated at baseline (soon after injury) for pre-injury charact...
Childhood traumatic brain injury (TBI) is one of the most common causes of acquired disability and has significant implications for executive functions (EF), such as impaired attention, planning, and initiation that are predictive of everyday functioning. Evidence has suggested attentional features of executive functioning require behavioral flexib...
Background and purpose
Large MRI studies often pool data gathered from widely varying imaging sequences. Pooled data creates a potential source of variation in structural analyses which may cause misinterpretation of findings. The purpose of this study is to determine if data acquired using different scan sequences, head coils and scanners offers c...
Objective:
White matter burden and medial temporal atrophy are associated with cognitive health. A large epidemiological database, such as the Cache County Memory Study (CCMS), can provide additional insight into how visual clinical ratings of brain structural integrity predict cognition in older adults.
Method:
We used the Scheltens Ratings Sca...
Objective:
Identification of patients with mTBI at risk for developing persistent-post concussive syndromes should begin during the ED/inpatient evaluation due to frequent lack of post-discharge follow-up. The best method for evaluating cognitive deficits in these acute settings and how to utilize this information to optimize follow-up care is a m...
Objective:
To determine if history of mild traumatic brain injury (mTBI) is associated with advanced or accelerated brain aging among the United States (US) military Service Members and Veterans.
Methods:
Eight hundred and twenty-two participants (mean age = 40.4 years, 714 male/108 female) underwent MRI sessions at eight sites across the US. Tw...
Objective:
The investigators examined the factors predictive of novel oppositional defiant disorder in the 6-12 months following traumatic brain injury (TBI).
Methods:
Children ages 5-14 years old who experienced a TBI were recruited from consecutive admissions to five hospitals. Participants were evaluated soon after injury (baseline) for prein...
Plasticity is often implicated as a reparative mechanism when addressing structural and functional brain development in young children following traumatic brain injury (TBI); however, conventional imaging methods may not capture the complexities of post-trauma development. The present study examined the cingulum bundles and perforant pathways using...
Objective:
The investigators aimed to assess predictive factors of novel oppositional defiant disorder (ODD) among children and adolescents in the first 6 months following traumatic brain injury (TBI).
Methods:
Children ages 5-14 years who experienced a TBI were recruited from consecutive admissions to five hospitals. Testing of a biopsychosocia...
The objective was to clarify occurrence, phenomenology, and risk factors for novel psychiatric disorder (NPD) in the first 3-months after mild traumatic brain injury (mTBI) and orthopedic injury (OI). Children aged 8-15 years with mTBI (n=220) and with OI but no TBI (n=110) from consecutive admissions to an emergency department were followed prospe...
Intelligence (IQ) scores are used in educational and vocational planning for individuals with autism spectrum disorder (ASD) yet little is known about the stability of IQ throughout development. We examined longitudinal age-related IQ stability in 119 individuals with ASD (3–36 years of age at first visit) and 128 typically developing controls. Int...
Objective:
The investigators aimed to extend findings regarding predictive factors of psychiatric outcomes among children and adolescents with traumatic brain injury (TBI) from 2 to 24 years postinjury.
Methods:
Youths aged 6-14 years who were hospitalized following TBI from 1992 to 1994 were assessed at baseline for TBI severity and for preinju...
The basics of structural neuroimaging identified neuropathological changes that may be identified on computed tomography and magnetic resonance imaging (MRI) associated with mild traumatic brain injury (mTBI), also known as concussion, are reviewed. Emphasis is placed on understanding the subtle nature of neuropathology that may accompany mTBI and...
Background:
An early approach to cognitive rehabilitation therapy (CRT) was developed based on A. R. Luria's theory of brain function. Expanding upon this approach, the Integrative Cognitive Rehabilitation Psychotherapy model (ICRP) was advanced.
Objective:
To describe the ICRP approach to treatment of clients post brain injury and provide a com...
Background:
Quantitative neuroimaging analyses have the potential to provide additional information about the neuropathology of traumatic brain injury (TBI) that more thoroughly informs the neurorehabilitation clinician.
Objective:
Quantitative neuroimaging is typically not covered in the standard radiological report, but often can be extracted...
Positive neuroimaging findings, when present, objectively demonstrate structural and functional brain abnormalities. Neuropsychological testing provides the framework that provides clinical correlation of abnormal brain states and their influence on cognitive, emotional, and behavioral functioning. Contemporary neuroimaging utilizes a network appro...
Autism spectrum disorder has long been associated with a variety of organizational and developmental abnormalities in the brain. An increase in extra-axial cerebrospinal fluid volume in autistic individuals between the ages of 6 months and 4 years has been reported in recent studies. Increased extra-axial cerebrospinal fluid volume was predictive o...
Objective
Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine associations between WM organization and neurobehavioral outcomes.
Methods
Data from ten...
The role of magnetic resonance (MR) neuroimaging in studying brain development in the first three decades of life is reviewed, in terms of its relevance to pediatric neuropsychology. This review places an emphasis on displaying development neuroimaging findings in various types of growth plots, diagrams and figures. MR imaging (MRI) methods can be...
Objective:
The study sought to present normative and psychometric data and reliable change formulas for the Health and Behavior Inventory (HBI), a postconcussive symptom rating scale embedded in the Child Sport Concussion Assessment Tool 5th edition (Child SCAT5).
Design:
Prospective cohort study with longitudinal follow-up.
Setting:
Pediatric...
This study is the first to examine cognitive outcomes following pediatric mild TBI using the National Institutes of Health Toolbox Cognition Battery (NIHTB-CB), a computerized cognitive test battery. The NIHTB-CB includes two complex measures of attention and executive function that allow differentiation of accuracy and response speed. We compared...
Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population, and specific developmental issues require a unique context since findings from adult research do not necessarily directly translate to chil...
Sport-related brain injury is very common, and the potential long-term effects include a wide range of neurological and psychiatric symptoms, and potentially neurodegeneration. Around the globe, researchers are conducting neuroimaging studies on primarily homogenous samples of athletes. However, neuroimaging studies are expensive and time consuming...
The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis)...
Intimate partner violence includes psychological aggression, physical violence, sexual violence, and stalking from a current or former intimate partner. Past research suggests that exposure to intimate partner violence can impact cognitive and psychological functioning, as well as neurological outcomes. These seem to be compounded in those who suff...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with unknown brain etiology. Our knowledge to date about structural brain development across the lifespan in ASD comes mainly from cross-sectional studies, thereby limiting our understanding of true age effects within individuals with the disorder that can only be gained through longit...
The identification of children with traumatic brain injury (TBI) who are at risk of death or poor global neurological functional outcome remains a challenge. Magnetic resonance imaging (MRI) can detect several brain pathologies that are a result of TBI, however, the types and locations of pathology that are the most predictive remain to be determin...
The objective of the study was to compare psychiatric outcomes in adults with and without history of pediatric traumatic brain injury (TBI). Youth 6 to 14 years of age, hospitalized for TBI from 1992 to 1994, were assessed at baseline and at 3, 6, 12, and 24 months post-injury. In the current study, psychiatric assessments were repeated at 24 years...
Sex differences after concussion have been studied largely in high school and college athletes, often without reference to comparison groups without concussion. This study sought to evaluate sex differences in outcomes among all children and adolescents presenting to the Emergency Department (ED) for either mild traumatic brain injury (TBI) or orth...
Region of interest (ROI) volumetric assessment has become a standard technique in quantitative neuroimaging. ROI volume is thought to represent a coarse proxy for making inferences about the structural integrity of a brain region when compared to normative values representative of a healthy sample, adjusted for age and various demographic factors....
Adolescent traumatic brain injury (TBI) is a major public health concern, resulting in over 35,000 hospitalizations in the U.S. each year.1 While neuroimaging is a primary diagnostic tool in the clinical assessment of TBI, our understanding of how specific neuroimaging findings relate to outcome remains limited. Our study aims to identify imaging b...
Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a characteristic abnormal central neurologic area(s) of abnormality pathognomonic to the disorder,...
The rapidly advancing field of neuroimaging has allowed scientists to examine brain processes in new and exciting ways. The study of cognitive rehabilitation has benefitted from these approaches by systematically quantifying changes in both behavior and corresponding brain structure and function. Some of the most common methods include the utilizat...
Automated neuroimaging methods like FreeSurfer (https://surfer.nmr.mgh.harvard.edu/) have revolutionized quantitative neuroimaging analyses. Such analyses provide a variety of metrics used for image quantification, including magnetic resonance imaging (MRI) volumetrics. With the release of FreeSurfer version 6.0, it is important to assess its compa...
Although childhood traumatic brain injury (TBI) has been linked to heightened risk of impaired social skills and behavior, current evidence is weakened by small studies of variable methodological quality. To address these weaknesses, this international multi-cohort study involved synthesis of data from two large observational cohort studies of comp...
Annually, approximately 3 million children around the world experience traumatic brain injuries (TBIs), of which up to 20% are characterized as moderate to severe (msTBI) and/or have abnormal imaging findings. Affected children are vulnerable to long-term cognitive and behavioral dysfunction, as injury can disrupt or alter ongoing brain maturation....
This study investigated patterns of cortical organization in adolescents who had sustained a traumatic brain injury (TBI) during early childhood to determine ways in which early head injury may alter typical brain development. Increased gyrification in other patient populations is associated with polymicrogyria and aberrant development, but this ha...
Sports-related concussions (SRCs) are typically characterized by transient neurologic deficits due to physiologic and metabolic brain injury. However, following an SRC, subsequent insults may lead to severe and permanent injury in the affected brain cells. We present the case of a 15-year-old female scholastic wrestler who developed acute encephalo...
Sports-related brain injury is very common, and the potential long-term effects include a widerange of neurological and psychiatric symptoms, and potentially neurodegeneration. Aroundthe globe, researchers are conducting neuroimaging studies on primarily homogenoussamples of athletes. However, neuroimaging studies are expensive and time consuming,...
White matter (WM) abnormalities, such as atrophy and hyperintensities (WMH), can be accessed via magnetic resonance imaging (MRI) following pediatric traumatic brain injury (TBI). Several methods are available to classify WM abnormalities (i.e. total WM volumes and WMHs), but automated and manual volumes and clinical ratings have yet to be compared...
Studies of brain morphometry may illuminate the effects of pediatric mild traumatic brain injury (TBI; e.g., concussion). However, no published studies have examined cortical thickness in the early injury phases of pediatric mild TBI using an appropriate comparison group. The current study used an automated approach (i.e., Freesurfer) to determine...
Objective:
To compare the relative predictive value of Marshall Classification System and Rotterdam scores on long-term rehabilitation outcomes. This study hypothesized Rotterdam would outperform Marshall Classification System.
Design:
The study employed an observational cohort design with a consecutive sample of 88 participants (25 females, mea...
During childhood and adolescence, traumatic brain injury (TBI) is a leading cause of death and disability. In survivors, TBI is associated with cognitive dysfunction and declines in adaptive behaviors. The orbitofrontal cortex (OFC), a region linked to personality and social functioning, is highly susceptible to injury in TBI. Here, we examined cor...
Childhood traumatic brain injury (TBI) affects over 600 000 children per year in the United States. Following TBI, children are vulnerable to deficits in psychosocial adjustment and neurocognition, including social cognition, which persist long-term. They are also susceptible to direct and secondary damage to related brain networks. In this study,...
Traumatic brain injury (TBI) is common among military personnel and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. This inconsistent presentation makes it difficult to establish or validate biological and imaging markers that could help improve diagnostic and prognostic accuracy in thi...
Mild traumatic brain injury (mTBI) accounts for the vast majority of all pediatric TBI. An important minority of children who have suffered a mTBI has enduring cognitive and emotional symptoms. However, the mechanisms of chronic symptoms in children with pediatric mTBI are not fully understood. This is in-part due to the limited sensitivity of conv...
Objective:
The nosology for classifying structural MRI findings following pediatric mild traumatic brain injury (pmTBI) remains actively debated. Radiologic common data elements (rCDE) were developed to standardize reporting in research settings. However, some rCDE are more specific to trauma (probable rCDE). Other more recently proposed rCDE have...
Some substances and prescribed medications appear to be associated with cognitive impairments across a variety of cognitive domains, although comparatively few studies address associations between drug use and cognitive function, and in some cases, the clinical importance of some of the associations between drug use and cognitive function remains u...
Due to a combination of advancing medical technology and the increasing age of the adult population, more adults are pursuing surgical intervention, particularly elective surgery, than ever before. Postoperative cognitive decline (POCD) describes either a transient or chronic change in cognitive function that comes as a result of anesthesia or surg...
While this chapter focuses on the cognitive consequences of cerebrovascular disease, it is also important to know that cerebrovascular disease is not a unitary condition but rather multiple conditions that affect the cerebrovascular health of the brain. These include obvious conditions such as ischemic and intracerebral hemorrhagic stroke, aneurysm...
Most commonly thought of as an autoimmune condition, multiple sclerosis (MS) represents the most common demyelinating condition and is, in fact, the most common neurological condition among young- and middle-aged adults. Multiple sclerosis has a significant negative impact on physical, perceptual, and cognitive functioning. Although reduced process...
This chapter discusses the epidemiological scope of Obstructive Sleep Apnea (OSA) and the characteristics and cause of cognitive impairments in OSA. OSA is a common medical condition and a significant public health concern, with increased rates in males and increased risk associated with obesity and age. Both observational and clinical research stu...
Although generally conceptualized as involving primarily abnormal anxiety regulation, the anxiety disorders as a group along with obsessive–compulsive disorder and post-traumatic stress disorder also appear associated with deficits in cognitive function in several cognitive domains, including attention, executive function, language, memory, and pro...
Deficits in attention and executive function appear to be fundamental aspects of attention-deficit, hyperactivity disorder, although impairment in executive function might not occur in all individuals who have attention-deficit, hyperactivity disorder. A crucial aspect of attention-deficit, hyperactivity disorder, though, is impairment in inhibitor...
Characterized by alterations in mood, both major depression and bipolar disorder are also associated with deficits in neuropsychological function across several cognitive domains, including impaired attention, executive function, language, and processing speed. The majority of findings indicate that these deficits are likely present early in the co...
Chronic pain is a common clinical condition that has a high lifetime prevalence, with significant morbidity and medical cost. An often overlooked aspect of chronic pain is the cognitive consequences. Findings on chronic pain and cognitive function reveal several important factors. First, patients with chronic pain appear to have worse cognitive fun...
As humans, we take all of the functions of the brain for granted—this magnificent organ regulates all aspects of cognitive, behavioral, sensory, and motor experiences but seems to run effortlessly. However, given its structural and physiological complexity, there are many ways that something may go wrong. It all begins with conception and a phenome...
Traumatic brain injury (TBI) represents a common occurrence that places the brain at risk. This chapter first deals with the various definitional issues related to TBI, where the principal definitional challenges occur with mild injuries, often referred to as concussions. While the majority who sustain a mild TBI recover and may not have any lastin...
While this chapter focuses on the cognitive consequences of cerebrovascular disease, it is also important to know that cerebrovascular disease is not a unitary condition but rather multiple conditions that affect the cerebrovascular health of the brain. These include obvious conditions such as ischemic and intracerebral hemorrhagic stroke, aneurysm...
This important book describes the effects of a range of medical, psychological, and neurological conditions on brain functioning, specifically cognition. After a brief introduction of brain anatomy and function focusing on neural systems and their complex role in cognition, this book covers common disorders across several medical specialties, as we...
The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis)...
Intimate partner violence includes psychological aggression, physical violence, sexual violence, and stalking from a current or former intimate partner. Experiencing intimate partner violence is associated with impaired neurocognitive and psychosocial functioning, mental illness, as well as structural brain alterations. These impairments seem to be...
Intimate partner violence includes psychological aggression, physical violence, sexual violence, and stalking from a current or former intimate partner. Experiencing intimate partner violence is associated with impaired neurocognitive and psychosocial functioning, mental illness, as well as structural brain alterations. These impairments seem to be...
Objective
Traumatic brain injury (TBI) sustained in childhood is associated with poor social outcomes. This study investigated the role of theory of mind (ToM) as a mediator of the relation between TBI and peer rejection/victimization and reciprocated friendships, as well as the moderating effect of parental nurturance on those relationships.
Meth...
Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population; however, research in this population lags behind research in adults. This may be due, in part, to the smaller number of investigators engag...
In addition to the positive and negative features, deficits in cognition appear to be an important aspect of Schizophrenia and are found in many cognitive domains, including attention, executive function, Schizophrenialanguage, memory, processing speed, and visuospatial ability. The Cognitive impairment associated with schizophrenia are present acr...
Many studies have found some deficits in Cognitive function in anorexia nervosa. While deficits in memory appear to be associated with anorexia nervosa, a more consistent finding is that anorexia nervosa appears to be associated with impairments in a variety of measures of executive function, and it is not clear how the Cognitive impairment that ar...
Infectious disease is caused by a variety of pathogens including bacteria, viruses, and fungi which are associated with peripheral and neural Inflammation. Recent investigations show that systemic Inflammation can lead to brain injury. This chapter will focus on Sepsis, a systemic illness which causes systemic Inflammation and multi-organ dysfuncti...
A number of Pulmonary disease, including chronic obstructive Pulmonary disease (Chronic obstructive pulmonary disease (COPD), Asthma, Acute respiratory distress syndrome (ARDS) (ARDS), not only effect the lungs but have well-described effects on the brain and behavior. Many individuals with Pulmonary disorders experience new and often severe morbid...
Carbon monoxide (CO) poisoning is one of the most common types of poisoning in the USA and can be either acute or chronic. CO poisoning is diagnosed through examination of the patients’ history and is confirmed by an elevated carboxyhemoglobin level. The symptoms of CO poisoning are often nonspecific including headache, nausea, vomiting, or other f...
Each chapter of Brain at risk, the has explored different ways in which the brain is vulnerable for disease and/or various disorders, including ones that are acquired. Some of the latest research is presented in an informative way describing risk and mitigating factors that influence the expression and course of some of the more common major medica...
Although diminished proficiency on tasks that require visual-motor integration (VMI) has been reported in individuals with autism spectrum disorder (ASD), very few studies have examined the association between VMI performance and neuroanatomical regions of interest (ROI) involved in motor and perceptual functioning. To address these issues, the cur...
