Eric Tirrell's research while affiliated with Butler Hospital and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (35)
[This corrects the article DOI: 10.3389/fpsyt.2022.877574.].
Introduction
Repetitive Transcranial Magnetic Stimulation (rTMS) has shown promising results in treating several Substance Use Disorders including Tobacco Use Disorder. However, questions remain regarding how to optimize treatment outcomes. Enhancement of working memory by rTMS is a potential therapeutic mechanism. The current pilot study examined...
Background
Most external peripheral nerve stimulation devices designed to alter mood states use electrical energy, but mechanical stimulation for activation of somatosensory pathways may be harnessed for potential therapeutic neuromodulation. A novel investigational device for Mechanical Affective Touch Therapy (MATT) was created to stimulate C-tac...
Background
Transcranial magnetic stimulation (TMS) is an effective therapy for patients with treatment-resistant depression. TMS likely induces functional connectivity changes in aberrant circuits implicated in depression. Electroencephalography (EEG) “microstates” are topographies hypothesized to represent large-scale resting networks. Canonical m...
Objectives
Mechanical Affective Touch Therapy (MATT) is a safe, novel form of noninvasive peripheral nerve stimulation. Although mechanical stimulation activates nerves, we know little about its impact on psychiatric symptoms and their underlying cortical mechanisms. We examined the effects of open-label MATT on resting state functional connectivit...
Background
Anhedonia is one of the defining features of depression but it remains difficult to target and treat. Transcranial magnetic stimulation (TMS) is a proven treatment for depression, but its effects on anhedonia and whether anhedonia can be used as a predictive biomarker of response is not well known.
Methods
Snaith–Hamilton Pleasure Scale...
Background: Mindfulness-Based Cognitive Therapy (MBCT) has been shown to enhance the long-term treatment outcomes for major depressive disorder (MDD), and engagement of specific brain activities during brain stimulation may produce synergistic effects. Audio-guided meditation exercises are a component of MBCT that might be combined with standard tr...
This exploratory study examined multiple units of working memory (WM) analysis in a transdiagnostic, treatment-seeking, pediatric sample. This included a) an electroencephalography marker of WM (coupling of theta and gamma oscillations [i.e., theta-gamma coupling] in frontal brain regions), b) WM test performance, and c) parent-reported WM symptoms...
Objectives:
To determine if vascular endothelial growth factor (VEGF) changes with transcranial magnetic stimulation (TMS) in treatment-resistant major depressive disorder (MDD).
Methods:
Serum from a naturalistic population of 15 patients with MDD was collected at baseline and after standard TMS treatment. VEGF concentration was determined via...
Introduction: Despite preliminary research, there remain inconsistent findings with regard to the role of executive functioning (EF) deficits in childhood anxiety and depression. This report examined the association of The National Institute of Health (NIH) Toolbox to clinical neuropsychological measures and to childhood, anxiety/depressive symptom...
Objectives:
Patients with major depressive disorder (MDD) who received electroconvulsive therapy (ECT) often seek transcranial magnetic stimulation (TMS) therapy as a less invasive treatment option. How prior history of ECT and its responsiveness may affect TMS treatment outcomes for MDD is unclear. We aim to contribute evidence to this important...
Background: The individual α frequency (IAF) has been associated with the outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD), but the association has been inconsistent. Hypothesis: Proximity of IAF to the stimulation frequency, rather than the value of IAF per se, is associated with outcome f...
Background
Behavioral Activation (BA) Therapy and Transcranial Magnetic Stimulation (TMS) have each been shown to be effective in the treatment of adult outpatients with major depressive disorder (MDD). Combining both treatments may produce synergistic antidepressant outcomes.
Methods
We developed a new protocol for incorporating a simplified vers...
Citations
... However, a significant limitation of combining NIBS with repetitive behavioural interventions (i.e., training sessions) is the risk of participant disengagement due to fatigue or boredom. A recent study even reported iatrogenic effects, such as worse cognitive performance and clinical outcomes, when TMS sessions were combined with working memory training interventions in individuals addicted to nicotine (Lechner et al., 2022). Thus, more feasible and ecologically valid combined interventions, including NIBS and psychotherapies (Dedoncker et al., 2021;Tatti et al., 2022). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279370691301381-1443618571283_Q64/Noah-Philip.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/294740118523906-1447282928132_Q64/Linda-Carpenter-2.jpg)
... This data-driven approach is helpful for studies on brain disorders exhibiting clinical symptoms due to aberrant networks. 16 Dynamic functional connectivity is a recurrent state of brain connectivity measurable on resting-state fMRI. It is associated with different cognitive and pathological states. ...
... Previous studies have reported power increases in the theta and alpha frequency bands as markers for enhanced mindfulness (16); these metrics were examined in our participants to evaluate the hypothesis that MATT exerts it actions through interoceptive pathways. fMRI data from this study is published separately (17). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/942674613911557-1601762550826_Q64/Meghan-Gonsalves.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1100373930582017-1639360997463_Q64/Andrew-Fukuda.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/274236635873310-1442394517935_Q64/Jennifer-Barredo.jpg)
... Meanwhile, integration of information inputs in the insula provides the prediction of a combination of pain, perceptual errors, or a variety of other current conditions (Geuter et al., 2017;Centanni et al., 2021). The integration of emotional and somatosensory signals is a crucial function of the insula (Gonsalves et al., 2021). Previous studies have confirmed that enhanced nociceptive sensitization in patients with chronic pain may be associated with overlapping pain activation in the insula (Ploghaus et al., 2001;Zhuo, 2016). ...
... Regarding the clinical manifestation, anhedonia is one of the core symptoms of depression [44] but it remains difficult to treat [45]. Cognitive abnormalities are also a core feature of depression, and involve attention, memory, executive functions, and psychomotor speed [46]. ...
... The 2016 study by Kim et al. (2016) had a task related activity of mental arithmetic. The goal of the preliminary study by Kavanaugh et al. (2021) was to investigate working memory performance and its relationship to theta-gamma PAC in a group of transdiagnostic, treatment-seeking, pediatric sample. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/766608930779137-1559785220982_Q64/Brian-Kavanaugh.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/898050906148864-1591123429651_Q64/Simona-Temereanca.jpg)
... Regarding VEGF, it has been demonstrated that individuals successfully treated with rTMS had a significant increase in VEGF after treatment compared to the baseline and the non-responders/non-remitters. Notably, the greater increase in VEGF was related to higher improvement in depressive symptomatology after TMS [117]. This provides correlative data that encourage future investigations exploring VEGF as both a key mediator in the process underlying the antidepressant effect of TMS and a possible marker of clinical outcome. ...
... 83 Additionally, worse executive functions are linked to lower QoL and mental health problems. [98][99][100] Hypoglycemia, hyperglycemia and DKA, especially if recurrent, can impact school functioning and educational attainment via a combination of mechanisms including altered cognitive function and nonattendance for acute treatment. 101 However, findings regarding the impact of T1D on academic performance in young people are mixed. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/911114812542978-1594238107803_Q64/Mary-Kathryn-Cancilliere.jpg)
... Subsequent studies examined other potential predictors of treatment response: one demonstrating a NPV of 72.3% when participants had <20% improvement at week two while using final outcomes of extended treatment courses of 10 Hz stimulation at the left dorsolateral prefrontal cortex (DLPFC) (12), and another finding a NPV of roughly 80% for a population receiving 1 Hz rTMS (13). Calculating metrics such as negative predictive value of early treatment response in clinical TMS populations allows clinicians to better prognosticate who will respond to subsequent therapy and aids in the decision making regarding altering or adapting treatment plans to optimize outcomes. ...
... Recent literature adds to the position that rTMS has less impact on cognitive functioning than ECT (Abdel Latif et al., 2020). However, it must be stressed that scientific consensus is that ECT-related cognitive deficits are not lasting, with a large body of evidence even pointing towards net positive effects of ECT on a number of neuropsychological outcome parameters (Semkovska and McLoughlin, 2010) In a retrospective analysis, a history of past ECT treatment did not turn out to be a significant independent predictor of rTMS outcome when matched for baseline severity and hospitalizations, indicating that having had ECT is no reason not to then undergo rTMS (Yuan et al., 2019). ...
