Eric Park’s research while affiliated with University of Florida and other places

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Publications (1)

Figure 1. Different ciliary mutants in lifespan regulation (A) An illustration of C. elegans sensory cilium showing multiple different ciliary components involved in ciliogenesis and maintenance. The impacts of these components (highlighted in red) on longevity are studied in subsequent experiments (B-H). (B) The daf-10(p821) mutant with defective intraflagellar transport particle A is significantly longer lived than wild-type (WT) worms. (C) The osm-1(p808) mutant with defective intraflagellar transport particle B is significantly longer lived than WT worms.
Figure 2. dve-1 RNAi suppresses ciliary mutations-conferred longevity (A) In addition to daf-16 RNAi, dve-1 RNAi strongly suppresses the greatly extended lifespan of daf-10(p821) mutant animals. (B) dve-1 RNAi strongly suppresses the isp-1 RNAi-induced mitoUPR activation. The zcls13[Phsp-6::gfp] transcriptional reporter line for mitoUPR 35 is used in this experiment.
Figure 3. The mitoUPR transcription factor ATFS-1 is not involved in ciliary modulation of longevity (A) Illustration of signaling pathways required for mitoUPR activation in C. elegans. Among them, two parallel pathways are centered around two transcription factors/regulators, ATFS-1 and DVE-1, both of which are highlighted in blue. (B-I) atfs-1 RNAi has no significant impacts on the lifespans of WT (B) and daf-10(p821) (C), osm-1(p808) (D), dyf-1(mn335) (E), osm-3(p802) (F), xbx-1(ok279) (G), klp-11(tm324) (H), and osm-12(n1606) (I) mutant worms.
Figure 4. Ciliary mutations-conferred longevity does not require mitoUPR (A) No changes of the hsp-6 mRNA level are observed in the long-lived daf-10(p821), normal-lifespan klp-11(tm324) or short-lived osm-12(n1606) mutant backgrounds,
Figure 6. DVE-1 acts in a mitoUPR-independent fashion downstream of dietary-restrictionmodulated and germline-signaling-modulated lifespan

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A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation
  • Article
  • Full-text available

October 2024

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34 Reads

Cell Reports

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Adriana Abreu

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Zachary Markovich

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[...]

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The special AT-rich sequence-binding (SATB) protein DVE-1 is widely recognized for its pivotal involvement in orchestrating the retrograde mitochondrial unfolded protein response (mitoUPR) in C. elegans. In our study of downstream factors contributing to lifespan extension in sensory ciliary mutants, we find that DVE-1 is crucial for this longevity effect independent of its canonical mitoUPR function. Additionally, DVE-1 also influences lifespan under conditions of dietary restriction and germline loss, again distinct from its role in mitoUPR. Mechanistically, while mitochondrial stress typically prompts nuclear accumulation of DVE-1 to initiate the transcriptional mitoUPR program, these long-lived mutants reduce DVE-1 nuclear accumulation, likely by enhancing its cytosolic translocation. This observation suggests a cytosolic role for DVE-1 in lifespan extension. Overall, our study implies that, in contrast to the more narrowly defined role of the mitoUPR-related transcription factor ATFS-1, DVE-1 may possess broader functions than previously recognized in modulating longevity and defending against stress.

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