Eric J. Battaglioli's research while affiliated with Kennesaw State University and other places

... Our stable isotope analysis indicated that ornithine is primarily an end product of growth and is relatively inaccessible as a carbon source for E. lenta. However, ornithine is a favorable carbon and/or energy source for numerous other gut microbes [23], including as a substrate for Stickland metabolism by gut bacteria including Clostridioides difficile [6,66,67]. Therefore, production of ornithine by E. lenta may promote the growth of other proteolytic bacteria in the surrounding gut ecosystem. ...

... Kna promoted expression of IL-23 and IL-17 in DCs and Th17 cells by inhibiting GPCR35 and downregulating AC and cAMP [75] Human hepatoma cell line HepG2 3-HAA 3-HAA inhibited inflammasome activation and IL-1b production by macrophages [76] IDO1 −/− , Qprt −/− , and WT mice NAD + Breakdown of de novo NAD + synthesis underlie declining NAD + levels and rising innate immune dysfunction in aging and age-associated diseases [77] Human hepatoma cell line HepG2 Indole Indole stimulated human AhR-mediated target gene expression [49] Gastric specimens of IDO1 −/− mice IAld Lactobacilli induced IL-22 via IAld [74] Calcipotriol (MC903)-induced AD-like dermatitis mouse IAId IAId attenuated skin inflammation in mice with MC903-induced atopic dermatitis-like dermatitis [21] Human endothelial cells IAA IAA activated an inflammatory non-genomic AhR/p38MAPK/NF-B pathway that induced the production of a pro-inflammatory enzyme, cyclooxygenase-2 [78] DSS-induced colitis mice IPA IPA increased the expression of IL-10 receptor on intestinal epithelia and ameliorated the DSS-induced colitis [79] Germ-free Swiss Webster male mice Tryptamine Tryptamine altered host gene expression profile responsible for regulating intestinal inflammation, cell survival, and proliferation [80] LV-shTPH2-injected rats 5-HT 5-HT depletion caused opposite changes in inflammatory versus neuropathic pain responses [81] Intestinal epithelial cell line Caco-2 5-HT Intracellular accumulation of 5-HT via SERT induces CYP1A1 expression via AhR in intestinal epithelial cells [82] a reduced mTOR signaling. [83] Largely depending on the mTOR signaling pathway, innate immune system cells can effectively activate the development of T-regs that induce autophagy. ...

... A retrospective study by Jacobs et al., patients with previous GI surgeries except for cholecystectomy were excluded; reported no difference in symptom profile between duodenal luminal culture positive and negative patients, regardless of predominant microbial organism [29]. Another recent report by Saffouri et al. found that presence of diarrhea, abdominal pain, and bloating did not correlate with positive aspirates; however, there was a correlation with duodenal microbiome diversity [30]. These findings suggest that culture-based assessment of small bowel micro-organisms may be a suboptimal technique and that dysbiosis, rather than luminal overgrowth, should be emphasized. ...

... AHL is also produced by enteric pathogens in the gut with dysbiosis [65,66], which might activate Tas2r/TAS2R subpopulations in the gut, thus inducing a host response. Furthermore, bacteria-derived small molecules have been shown to alter host GI function by activating serotonin receptors and increasing fluid secretion, and microbiome alterations have been associated with biological effects of gut receptor signaling on nutrients and caloric intake [67,68]. Selective alterations in gut microbiota have also been shown to stimulate endogenous gut hormones production, with consequent beneficial effects on host physiology [69]. ...

... The impact of the microbial communities on human health is undoubtedly promising . However, unhealthy lifestyle (Hernández-Quiroz et al., 2020), poor food habits (Battaglioli and Kashyap, 2018), frequent antibiotic usage (Bhalodi et al., 2019) are stressing the gut microbiome structure and pushing a huge fraction of the population toward the onset of the microbial dysbiosis related disorders. These dysbiosis related disorders become key challenges for the health sector. ...