Eric E. Harrison’s research while affiliated with Tampa General Hospital and other places

Questions regarding the relative safety and efficacy of internal mammary artery (IMA) grafts versus saphenous vein grafts (SVG) in patients with left main coronary artery disease (LMCAD) have not been specifically addressed in the literature. To elucidate this point, we analyzed 196 patients with LMCAD who underwent myocardial revascularization between January 1975 and December 1981, 98 by IMA and SVG and 98 by SVG, IMA was used most often to bypass the left anterior descending (LAD). Chi Square and "t" tests were performed on all demographic, cardiac and operative data comparing IMA to SVG. All results were non-significant, indicating that the two groups were comparable. Anginal pattern was progressive or unstable in 93%. IMA was used in 4 patients who were on intra-aortic balloon pump. The mean number bypass grafts per patient was 3.1. Postoperative complications were comparable for both groups, including early and late myocardial infarction. Overall operative mortality was 2.6%. Results of a survival analysis indicated no significant difference in the mortality rates of patients operated on by SVG versus IMA-SVG. Cumulative mortality rates at a mean followup of 20.5 months were 12.2% for SVG and 7.1% for IMA patients. Significant mortality risk factors were ejection fraction less than 55% (p less than 0.05); and perioperative myocardial infarction (p less than 0.001). Twenty-five patients with recurrent chest pain underwent repeat cardiac catheterization. This revealed 10 of 10 patent IMA grafts, 6 of 8 single patent SVG to LAD and 6 of 9 patent sequential vein grafts to the diagonal and LAD arteries.(ABSTRACT TRUNCATED AT 250 WORDS)

Technical factors in mitral valve surgery (MVS) which may influence neurological complications, trauma to the left atrium and formation of atrial mural thrombi have not previously been described in detail. We have reviewed the records of 146 patients (pts) undergoing MVS through the superior approach between January 1974 and May 1981. The series consisted of 97 females and 49 males with a mean age of 57 +/- 18 years. All but 4 pts were in New York Heart Association functional class III or IV. Twenty-five pts underwent open mitral commissurotomy, 116 had valve replacement and 5 had annuloplasty. Concomitant procedures were coronary bypass in 47, aortic valve replacement in 18 and resection of left ventricular aneurysm in 3. Left atrial thrombi were removed in 21 pts. Thirteen pts (9%) died postoperatively. The causes of death were left ventricular failure in 7, arrhythmia in 4 and atrio-ventricular disruption in 2. Two of these pts also had cerebral dysfunction. Autopsy examination in 8 pts failed to reveal formation of fresh left atrial septal or posterior mural thrombus. Postoperative complications included transient neurologic injury presumed to be due to air embolus in 3 and postoperative bleeding from atrial suture line in one. The mean follow-up for the survivors has been 30 months. There have been 16 (12%) late deaths from 1 to 72 months (mean 15). Autopsy examination of 4 pts and surgical exploration in one other pt which failed to reveal organized left atrial mural thrombus. Only one late death was related to prosthetic thrombosis. This occurred following cessation of anticoagulations.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium is recommended by American Heart Association standards for the resuscitation of patients with electromechanical dissociation (EMD). Until recently, only anecdotal case reports were offered to support this recommendation. Recent studies examining the question of whether calcium is useful in resuscitating hearts in EMD are reviewed.

All records of cardiac arrest patients presenting to the Tampa EMS system for the 24-month period of January, 1980, through December, 1982, were reviewed. Paramedics were given direct orders or standing orders to administer calcium intravenously or intracardiac in patients in ventricular fibrillation, asystole, or electromechanical dissociation. Of the 480 patients receiving calcium for the above conditions, only patients with electromechanical dissociation responded to calcium. Twenty-seven EMD patients responded positively with the immediate return of blood pressure and pulse. Fourteen of these patients arrived at the emergency department with stable vital signs; there were three long-term survivors. Adverse rhythm or rate changes were not noted following calcium use, and arrhythmias associated with digitalis excess were not seen in a small group of patients taking digoxin. Although long-term survivors are limited in this group of patients, positive hemodynamic responses were seen following calcium chloride administration in 10% of EMD patients and not at all in patients with asystole or ventricular fibrillation.

A review of perioperative complications of cardiac procedures at Tampa General Hospital revealed a distinct preoperative finding in several patients having embolism after coronary artery bypass grafting (CABG). From a total of over 10,000 cardiac catheterization procedures, four patients had ventricular wall motion abnormalities with discrete, mobile, pedunculated filling defects noted during ventriculography. Three of these patients eventually underwent CABG, and each had a postoperative embolic episode. A similar catheterization finding was noted in a fourth patient, who later had an embolic event. Thus, even in the absence of a discrete aneurysm, this observation suggests the need for an aggressive surgical approach to CABG patients with these ventricular filling defects.

A review of perioperative complications of cardiac procedures at Tampa General Hospital revealed a distinct preoperative finding in several patients having embolism after coronary artery bypass grafting (CABG). From a total of over 10,000 cardiac catheterization procedures, four patients had ventricular wall motion abnormalities with discrete, mobile, pedunculated filling defects noted during ventriculography. Three of these patients eventually underwent CABG, and each had a postoperative embolic episode. A similar catheterization finding was noted in a fourth patient, who later had an embolic event. Thus, ***ever in the absence of a discrete aneurysm, this observation suggests the need for an aggressive surgical approach to CABG patients with these ventricular filling defects.

Bretylium tosylate is recommended by the American Heart Association Standards for Advanced Cardiac Life Support for refractory ventricular fibrillation after countershock, sodium bicarbonate, and epinephrine. According to this protocol, paramedics gave five to six milligrams per kilogram of intravenous bretylium by bolus in 96 patients with refractory fibrillation over a 24-month period. A positive response was defined as the presence of a palpable pulse following bretylium and countershock. Thirty-five percent of patients (34/96) responded following bretylium. Twenty-one percent (20/96) responded only temporarily with a rhythm and pulse. Fifteen percent (14/96) maintained a stable rhythm and vital signs on admission to the hospital, but only five patients, 5% of the total population, (5/96), were eventually discharged home. Clinical variables were similar in non-responders, temporary responders, and those admitted, but the times from the onset of Advanced Cardiac Life Support to receiving bretylium were 23.5 min, 20.3 min, and 14.3 min respectively. We conclude that about one-third of patients in refractory ventricular fibrillation respond following bretylium and countershock and that earlier bretylium use may give better results.

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