Emmanuel Rodriguez-Chavez's research while affiliated with Mexican Institute of Social Security and other places
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Publications (11)
The vertiginous advance for identifying the genomic sequence of SARS-CoV-2 allowed the development of a vaccine including mRNA-based vaccines, inactivated viruses, protein subunits, and adenoviral vaccines such as Sputnik. This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. Patients a...
Prolactin (PRL) is a polypeptide hormone that has been reported to play a significant role in neuroprotection against neuronal excitotoxicity produced by glutamate (Glu) or kainic acid (KA) in both, in vitro and in vivo models. However, the molecular mechanisms involved in PRL's neuroprotective effects in the hippocampus have not been completely el...
One condition recently associated with coronavirus disease 2019 (COVID-19) is autoimmune encephalitis (AE). This disease presents deficits in cognition, memory, psychosis, abnormal movements, seizures, and coma. All previously reported cases were associated with antibodies against the N-methyl-d-aspartate receptor (anti-NMDAR).
The presence of ant...
Objective: To describe the obstetric history of Mexican patients with NMO-IgG (+) neuromyelitis optica (NMO).
Background: The influence of NMO in pregnancy is still unclear. A retrospective study found that, in NMO-IgG (+) women, 13% of pregnancies ended in spontaneous abortion. There are potential ethnic influences in NMO. The obstetric outcome o...
Background: The influence of neuromyelitis optica (NMO) in pregnancy is still unclear. A retrospective study found that, in women positive for NMO-IgG (NMO-IgG [+]), 13% of pregnancies ended in spontaneous abortion. There are potential ethnic influences in NMO. The obstetric outcome of Mexican patients with NMO-IgG (+) NMO is currently unknown.
Ob...
Clinical and experimental evidence provided evidences for involvement of inflammatory processes in the brain in the etiopathogenesis of seizures. The innovative view is that brain inflammation may be a common substrate contributing to seizures in drug-resistant epilepsies of different etiologies, and recurrent seizures can per se be a major cause o...
Background / Purpose:
We describe the neural networks in patients with multiple sclerosis (MS) and pseudobulbar affect.
Main conclusion:
Resting state cortico-cerebellar networks are absent in MS patients and pseudobulbar affect.
Citations
... [3][4][5] While, there are various side effects of COVID-19 vaccinations 6,7 including immune-mediated disease. [8][9][10][11][12] The development of vaccine-induced immune thrombosis with thrombocytopenia (VITT) has primarily been considered a serious complication of COVID-19 vaccination. 13 Most cases of VITT have been associated with vaccines that utilize a recombinant adenoviral vector encoding the spike protein antigen. ...
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... NF-κB also influences the balance between neuronal survival and apoptosis. In some cases, NF-κB activation can promote the expression of antiapoptotic genes, supporting neuronal survival [10]. However, chronic NF-κB activation can lead to a pro-apoptotic response in other situations. ...
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... Particular Case of COVID-Linked Encephalitis Some cases were marked by identification of specific neural antibodies. Three patients suffered from NMDA encephalitis [68,73,88]. Clinical manifestations were psychotic symptoms and seizures only. ...
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... It has been proposed that SARS-CoV-2's molecular mimicry may induce anti-NMDAR encephalitis after COVID-19 [66]. This may be a key mechanism beneath CNS manifestations of COVID-19 disease and vaccination associated with anti-NMDAR antibodies [14,67]. ...
... Thus, inflammatory mediators, such as cytokines, chemokines, and prostaglandins secreted by brain cells during epileptic activity, not only promote inflammation but also act as neuromodulators that affect neuronal function and increase excitability. 19 The pathological relevance of neuroinflammation is reinforced by the finding that it is a common feature of epilepsy in various drug-resistant forms with different etiologies and is not only related to autoimmune disorders or active CNS infections. 12,[20][21][22] In addition, inflammatory mediators are endowed with CNS-specific neuromodulatory functions that may contribute to hyperexcitability and excitotoxicity. ...
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