Emiri Hirokawa's research while affiliated with City University of New York - Hunter College and other places

Publication (1)

A new diterpene with a fused 5-8-5 ring system was isolated from the fermentation broth of a soil actinomycete. The stereochemistry at C-15 was determined in an unusual manner using a decomposition product.


... They were first isolated as glycosides from the phytopathogenic fungus Fusicoccum amygdali, in 1964 [81]. Substances exhibiting this structural motif have been isolated from a variety of sources including fungi such as Talaromyces purpureogenus, Alternaria brassicicola XXC, and Trichoderma citrinoviride cf-27 ( Figure 3), and rarely from liverworts, algae, ferns, streptomycetes, and higher plants, some of which showed remarkable biological effects relevant for drug discovery, such as antibacterial, antitumor, anti-inflammatory, and antifungal activities [82][83][84][85][86][87][88][89]. A new diterpenoid roussoellol C 26 that exhibited moderate antiproliferative activities against human breast adenocarcinoma (MCF-7) cell line with an IC50 value of 6.5 μM has been isolated from an extract of laboratory cultures of the marine-derived fungus Talaromyces purpurogenus [90]. ...