Emily K. Chivers's research while affiliated with Telethon Kids Institute and other places

Publications (10)

Preprint
Full-text available
Prenatal alcohol exposure (PAE) is associated with changes to offspring DNA methylation and adverse neurodevelopmental outcomes. Prior studies have utilised candidate gene or microarray approaches resulting in biased representation of the methylome. We employed an established experimental murine model of moderate PAE until gestational days 8-10, wi...
Article
Full-text available
Despite their increasing popularity, and Australia’s unique regulatory environment, how and why Australian adults use e-cigarettes and their perceptions of their safety, efficacy and regulation have not been extensively reported before. In this study, we screened 2217 adult Australians with the aim of assessing these questions in a sample of curren...
Article
Introduction: Electronic cigarettes (e-cigarettes) are often perceived to be safer than smoking, which has led to some women switching to e-cigarettes during pregnancy. However, the effects of switching from smoking to e-cigarettes on both pregnancy outcomes and the fetus are largely unknown. This study aimed to investigate the effects of switchin...
Article
Key points: Long-term exposure to elevated levels of atmospheric CO2 is an uncontrolled experiment already underway. This is the first known study to assess non-respiratory physiological impacts of long-term (conception to young adulthood) exposure of mice to CO2 at levels that may arise in the atmosphere due to global emissions. Exposure to eleva...
Article
Background: Climate change models predict that atmospheric carbon dioxide [CO2] levels will be between 700 and 900 ppm within the next 80 y. Despite this, the direct physiological effects of exposure to slightly elevated atmospheric CO2 (as compared with ∼410 ppm experienced today), especially when exposures extend from preconception to adulthood,...
Article
Full-text available
Smoking continues to be a burden to economies and healthcare systems across the world. One proposed solution to the problem has been e-cigarettes; however, as a relatively new product in the market, little is known about their potential health impacts. Furthermore, e-cigarettes continue to evolve at a rapid rate, making it necessary to regularly re...
Article
Full-text available
Background Epidemiological studies have identified strong relationships between maternal obesity and offspring respiratory dysfunction; however, the causal direction is not known. We tested whether maternal obesity alters respiratory function of offspring in early life. Methods Female C57Bl/6 J mice were fed a high or low fat diet prior to and dur...
Chapter
Maternal malnutrition during pregnancy alters the growth and development of the fetus and associates with adverse adult health outcomes in the offspring. Frequently underlying these associations is overexposure of the fetus to glucocorticoids. Fetal exposure to glucocorticoids is primarily regulated by 11β-HSD2, which catalyzes the intracellular in...

Citations

... This increase in CO 2 concentration in the atmosphere has raised questions regarding the ramifications of such a drastic change; it was found that~60% of the global warming effects being attributable to CO 2 emissions 2 . Not only has the increase in CO 2 concentrations been proven to have impacts on the climate, but it also has potentially negative effects on mammalian physiology 3 . Carbon capture and storage (CCS) technologies will play a role in offsetting the accumulation of this gas and thus negate the drawbacks of using carbon-intensive technologies. ...
... A question about the capacity of forests to store carbon under the high CO2 is raised [45]. The lungs of mice are sensitive to CO2 [46]. High CO2 exposure affects the lung function of female mice, which can be due to changes in blood chemistry [47]. ...
... 21 Lifelong cigarette smoking harms nearly every organ of the body and reduces life expectancy by ~10 years, [22][23][24] although there is a long latency period. 25 There are well-established biomarkers for disease from cigarette smoking 26 and a developing list of biomarkers for potential disease from e-cigarettes, [27][28][29] although none reach the criteria needed to be markers of clinical disease onset, 30 nor considered adequate to be included in screening modalities for lung cancer. 31 Despite this uncertainty, some have used such biomarkers to predict future disease risk, suggesting that e-cigarettes are much safer than cigarettes. ...
... Propylene glycol is a thinner liquid that produces a stronger throat hit and a more intense flavor, while VG is a thicker liquid that produces more vapor and a sweeter taste. The ratio of PG to VG in an e-liquid can affect the overall flavor, throat hit, and vapor production [32,33]. Flavorings are added to e-liquids to provide a wide range of tastes and aromas [34]. ...
... Specifically, higher maternal scaled mass index and increasing years in captivity were both associated with decreased offspring survival. In other taxa, maternal diet and obesity can impact the survival of offspring or their risk of obesity (Rivera et al., 2015;Smoothy et al., 2019). ...
... Over the progress of fetal programming research, it became clear that nutritional deprivation was not the only prenatal stressor that could lead to maladaptive phenotypes. Malnutrition has been hypothesized to influence programming through several mechanisms, such as inflammation, oxidative stress, dysregulated metabolism, a decrease in placental enzymes, and an increase in steroidal hormones [30,31]. Maternal plasma glucocorticoid levels have been shown to be increased with food restriction, along with the activation of the hypothalamic-pituitary-adrenal axis and a decrease in glucocorticoid-binding factors, leading to higher concentrations of active hormones free to interact with the fetus [32,33]. ...