Elisa Araldi's research while affiliated with Johannes Gutenberg-Universität Mainz and other places
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Publications (3)
Lithium is a nutritional trace element that is also used pharmacologically for the management of bipolar and related psychiatric disorders. Recent studies have shown that lithium supplementation can extend health and lifespan in different animal models. Moreover, nutritional lithium uptake from drinking water was repeatedly found to be positively c...
Aging is impacted by interventions across species, often converging on metabolic pathways. Transcription factors regulate longevity yet approaches for their pharmacological modulation to exert geroprotection remain sparse. We show that increased expression of the transcription factor Grainyhead 1 (GRH-1) promotes lifespan and pathogen resistance in...
The ability of pancreatic β-cells to respond to increased demands for insulin during metabolic stress critically depends on proper ribosome homeostasis and function. Excessive and long-lasting stimulation of insulin secretion can elicit endoplasmic reticulum (ER) stress, unfolded protein response, and β-cell apoptosis. Here we show that the diabete...
Citations
... Overall the motifs point can be related to cell cycle regulation and are consistent with the interpretation of nTA hi as a marker for chromatin condensation. However, we expect that more information can be extracted, e.g., GRHL1 has also been linked to aging, although in an insulin related manner 22 . Per-cell nTAs are available on Github for further exploration. ...
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... Cldn4, Cldn3, and Cldn7 are all upregulated in Beta 3 cells and associated with mature β-cell function [40]. Beta 3 cells upregulate 7 ribosome genes and elevated ribosome biogenesis is associated with increased β-cell apoptosis [41], β-cell replication [23], and mature β-cell function [42], making the functional relevance of overexpression unclear. One gene, Rpl7, is associated with mature β-cell function [43], while Rpl23 protects against apoptosis [44]. ...
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