Eli Somekh's research while affiliated with Mayanei Hayeshua Medical Center and other places

Publications (132)

Article
Owing to increasing populations and global threats, the integrity and safety of global food chains are at risk. In many countries, simply getting enough to eat can be an issue, with poor quality food often contaminated with hazardous agents, whereas in developed countries the pressure to deliver cheap, affordable food may affect quality and safety....
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Background Estimating real-world vaccine effectiveness is challenging since a variety of population factors can impact vaccine effectiveness. We aimed to assess the population-level reduction in cumulative SARS-CoV-2 cases, hospitalizations and mortality due to the BNT162b2 mRNA COVID-19 vaccination campaign in Israel during January-February, 2021....
Article
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The Bacillus Calmette–Guérin (BCG) vaccine affords indirect protection against COVID-19, which is presumably due to priming of the innate immune system. It was hypothesized that the live attenuated Varicella Zoster (LAVZ) vaccine, recommended for the elderly population, would also protect against COVID-19 infection. A retrospective population-based...
Article
Aim To examine and compare the medical burden of measles, influenza and COVID-19 outbreaks in the city of Bnei Brak, Israel. Methods The study was conducted during 2018-2021. The numbers of hospitalisations for these infections, their complications were recorded. Hospitalisation rates were determined by using the number of children residing in Bne...
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Background Child abuse and neglect, or maltreatment, is a serious public health problem, which may cause long-term effects on children’s health and wellbeing and expose them to further adulthood vulnerabilities. Studies on child maltreatment performed in Europe are scarce, and the number of participants enrolled relatively small. The aim of this mu...
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The relative increase in coronavirus disease incidence during summer 2020 in Israel was most prominent in young children. This finding contrasts with the lower increase in incidence observed in children than in adults during the school attendance period. School closure without lockdown conditions might not be independently effective at reducing spr...
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Objective We compared neonatal immunity after vaccination against SARS-CoV-2 during pregnancy to that achieved after maternal infection. Study design We tested cord blood from women infected with SARS-CoV-2 during pregnancy (group 1, n = 29), women who were vaccinated during pregnancy (group 2, n = 29) and from women not infected and not vaccinate...
Article
This paper presents the largest cohort to date of infants under 1 year of age treated with mebendazole. We evaluated the occurrence of mebendazole-associated clinical and laboratory toxicity as safety data in this age group are currently lacking.
Article
Background Most pediatric coronavirus disease 2019 (COVID-19) is mild. We assessed nationally severe COVID-19, including pediatric inflammatory multisystem syndrome (PIMS), in hospitalized children. Methods An ongoing, prospective, national surveillance was conducted from March 2020 through March 2021, at 20 hospitals treating children <18 years a...
Article
The dynamics of intrafamilial spread of SARS-CoV-2 during January-February 2021 when variant B.1.1.7 predominated were compared with data from April to May 2020, when other circulating variants prevailed. Much higher intrafamilial transmission rates among all age groups, in particular in young children, and lower rates of sensory impairment were de...
Preprint
School reopening on May 2020 did not have a major effect on SARS-CoV-2 resurgence in Israel during June-July. Rather, the easing of restrictions on large-scale gatherings was primarily responsible for this resurgence, and the increased hospitalizations and mortality.
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Background: The benefits of school reopening must be weighed against the morbidity and mortality risks and the impact of enhancing spread of COVID-19. We investigated the effects of school reopening and easing of social distancing restrictions on the dynamics of SARS-CoV-2 infections in Israel, between March-July 2020. Methods: We examined the n...
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Background There is limited data regarding the safety of vaginal delivery in women infected with COVID-19. Our goal was to assess the safety of vaginal delivery in women infected with COVID-19 and the risk of neonatal infection. Methods This was a single medical center cohort study. Data were collected about the outcome of twenty-one women with la...
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The article describes and discusses several key elements of the paediatric healthcare system in Israel, including paediatric training, family and community paediatrics, hospital-based paediatric services, preventive care services, and special programs such as the "Drop of Milk" (Tipat Halav) program. Although child care in Israel has gained several...
Article
Among individuals who tested positive for coronavirus disease 2019, smell and taste sensations were significantly less impaired among children than among adults, in a stepwise manner. Sensory impairment was correlated with recent data of angiotensin-converting enzyme 2 expression in the corresponding age groups. This is the first report to compare...
Article
We examined the dynamics of coronavirus 2019 (Covid-19) transmission within families. Our investigation demonstrated significantly lower rates of Covid-19 positivity in children compared with adults residing in the same household. Children of 5-17 years of age were 61% and children of 0-4 years of age were 47% less likely to have positive polymeras...
Conference Paper
Introduction Rates of community acquired methicillin resistant staphylococcus aureus (MRSA) in Israel is quite low and estimated at the range of 3% out of staphylococcus aureus isolates. This survey has been undertaken due to clinical impression of significant rise at the rates of MRSA isolates during the last few years in a closed community in Isr...
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Background Passive immunization against RSV (Respiratory Syncytial Virus) is given in most western countries (including Israel) to infants of high risk groups such as premature babies, and infants with Congenital Heart Disease or Congenital Lung Disease. However, immunoprophylaxis costs are extremely high ($2800–$4200 per infant). Using cost-utilit...
Article
To monitor parental vaccine attitudes, a survey was conducted in 2008 and in 2016. In both years (90%-89%) reported full immunization of their children, and a stable majority (71%-66%) supported documentation of vaccination before entering kindergarten. However, a declining confidence in official recommendations from 87% to 72% (p<0.0001) in 2008 a...
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Bartonella quintana endocarditis, a common cause of culture-negative endocarditis in adults, has rarely been reported in children. We describe 5 patients 7–16 years of age from Ethiopia with heart defects and endocarditis; 4 cases were caused by infection with B. quintana and 1 by Bartonella of undetermined species. All 5 patients were afebrile and...
Article
Israel is home to a child-oriented society that values strong family ties, universal child benefits, and free education for all children from 3 years of age to school grade 12. Alongside the universal health-care services that are guaranteed by the National Health Insurance Law and strong, community-based primary and preventive care services, these...
Article
Aims: The aim of these guidelines is to update and extend evidence-based recommendations for the diagnosis and management of children with acute gastroenteritis (AGE) in Israel, based on new data and the recently published European update. Methods: The recommendations, which are based on a systematic review of the literature, were graded by the...
Article
Background: Approximately 10%-20% of patients with Kawasaki disease (KD) are refractory to initial intravenous immunoglobulin (IVIg) therapy, and these "nonresponders" are at higher risk of coronary artery abnormalities. Early identification of these patients, who may benefit from additional therapy, is challenging. The aim of the present study is...
Article
Israel is a relatively rapidly growing country with a high fertility rate and a young population. These data emphasize the importance of an efficient and appropriate pediatric service for its population. Although the pediatric service in Israel has attained several achievements, such as a relatively low infant mortality, high vaccination rates, and...
Article
Background: During 2013-2014 Israel experienced a continuous circulation of wild poliovirus type 1 (WPV1) but with no clinical cases. WPV1 circulation was gradually terminated following a national vaccination campaign of bivalent oral poliovirus vaccine (bOPV) for 943,587 children < 10 years. Four cases of children with neurological manifestations...
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Background: Campylobacter spp. has been identified as one of the leading causes of bacterial gastroenteritis in the world. In recent years, an increase was demonstrated in the incidence of campylobacteriosis in several countries, including Israel. The incidence rate of campylobacteriosis in Israel increased from 22.3 per 100000 in 1997 to 77.4 per...
Article
In 2013, a silent wild poliovirus type 1 importation and sustained transmission event occurred in southern Israel. With the aim of preventing clinical poliomyelitis and ensuring virus re-elimination, the public health response to the importation event included intensification of clinical and environmental surveillance activities, enhancement of vac...
Article
Odontogenic infections may result in local, systemic, and even potentially life-threatening complications. The authors investigated whether water fluoridation was associated with reduction in rates of hospitalizations due to odontogenic infections. The authors included cities in Israel that had fluoride concentrations of either 0.7 milligrams per l...
Article
AimThe precise role of the influenza virus in the morbidity of hospitalised paediatric pneumonia cases is unknown. We identified how many cases hospitalised during the 2009 pandemic had influenza associated pneumonia and assessed their severity.Methods Children admitted to three Israeli medical centres during the 2009 influenza pandemic with radiol...
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Wild poliovirus type 1 (WPV1) introduction into southern Israel in early 2013 was detected by routine environmental surveillance. The virus was identified genetically as related to the South Asian (SOAS) R3A lineage endemic to Pakistan in 2012. Intensified, high-throughput environmental surveillance using advanced molecular methods played a critica...
Article
Unlabelled: In this prospective study, we examined the usefulness of C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells (s-TREM-1), and procalcitonin (PCT), in identifying serious bacterial infection (SBI) among neonates. Infants younger than 3 months with suspected SBI were included and serum concentrations of CRP, P...
Article
Israel has been certified as polio-free by the World Health Organization and its routine immunisation schedule consists of inactivated poliovirus vaccine (IPV) only. At the end of May 2013, the Israeli Ministry of Health (MOH) has confirmed the reintroduction of wild-type poliovirus 1 into the country. Documented ongoing human-to-human transmission...
Conference Paper
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Background: The 7-valent pneumococcal conjugated vaccine (PCV7) was introduced to the Israeli national immunization plan (NIP) in July 2009, with a fast reduction of PCV7 serotypes disease (Ben-Shimol et al. Vaccine 2012 ;30:6600-7). In November 2010, PCV13 was introduced to the Israeli NIP without any catch-up and gradually replaced PCV7. Our aim...
Article
Background: The incidence and the clinical characteristics of neonatal herpes simplex virus (NHSV) infection in Israel are unknown. Methods: We reviewed the medical records of NHSV cases who were born between January 2001 and December 2007 in 5 medical centers located in central Israel. Cases were identified using International Classification of...
Article
Data regarding the compliance and safety of oseltamivir in infants < 1-year-old are limited. To compare the rates of adverse effects and compliance with oseltamivir treatment among hospitalized children aged < 1-year-old with suspected influenza and older children. A telephone follow-up was carried out with parents of children admitted to hospital...
Article
This study was performed during an era of partial vaccination with varicella vaccine in Israel to characterize ambulatory pediatric herpes zoster (HZ) cases in a population with partial varicella vaccination coverage. Data were collected from computerized databases of a population of 114,000 children. Records of children aged 0-18 years, diagnosed...
Article
We report a case of an 11-year-old girl with Coxiella burnetii infection of a bovine jugular vein conduit which is an extremely rare manifestation of Q fever. The role of surgery in the management of C. burnetii endovascular infection and the use of serology are discussed.
Article
We aimed to define the excess morbidity associated with bloodstream infections (BSIs), imposed by pandemic H1N1 influenza during 2009-2010 (pH1N1/2009-2010) and seasonal influenza. Eight hospitals, accounting for 33% of hospitalizations in Israel, provided data on BSI during 2006-2010. The age-specific incidence of BSI due to Streptococcus pneumoni...
Article
Antibiotic overuse is of great public health concern. This study assessed whether intervention among physicians and their treated population could achieve a sustained reduction in antibiotic use, specifically in classes known to promote antibiotic resistance among children in a community setting. We performed a cluster randomized controlled multifa...
Article
The relative frequency of the different forms of SCID may vary in different countries. The most frequent form in Israel is the autosomal-recessive T-B- SCID or Omenn syndrome while X-linked SCID is rare. We report our immunological and genetic analyses in multicentre study of patients presenting with either T-B- SCID or Omenn syndrome. Among 16 pat...
Article
To describe the clinical characteristics of children hospitalized with 2009 influenza A(H1N1) infection in Israel and the risk factors associated with this infection. Prospective collection of data on children hospitalized with 2009 influenza A(H1N1) infection. Seven medical centers around Israel. Patients From July 12, 2009, to December 24, 2009,...
Article
While the burden of rotavirus infection with regard to hospitalizations has been extensively investigated, there are sparse data on the cost and impact of this infection on the ambulatory part of the health system in Israel. To investigate the burden of rotavirus infection on the ambulatory system in Israel. Infants younger than 3 years examined fo...
Article
The inflammatory process in the post-appendectomy period is not well characterized. In a pilot study, we prospectively followed the kinetics of different inflammatory mediators before and after appendectomy in children, and compared the results of the groups open appendectomy (OA) and laparoscopic appendectomy (LA). Levels of sP-selectin, tPA, MCP-...
Article
Insulin-dependent diabetes mellitus is dominated by a Th1 response whereas atopic diseases such as asthma, eczema and allergic rhinitis are characterized by a Th2 response. Because it is known that Th1 and Th2 cells reciprocally counteract each other, it can be speculated that the prevalence of Th2-mediated diseases is lower in patients with a Th1-...
Article
Knowledge about the natural history of food allergy, especially sesame, is scarce. To follow the natural history of food allergies in Israel, particularly of sesame allergy. The survey was conducted based on clinical records and a detailed questionnaire of children diagnosed as having food allergy. We found 234 children with suspected food allergy....
Conference Paper
Background: Delayed sternal closure (DSC) is an effective approach for the management of neonates and infants undergoing cardiac surgery who are at risk for life threatening cardio-respiratory instability. The information regarding the infectious complications of DSC is limited, and there are no recommendations for antibiotic prophylaxis in this se...