Elhoussine Derwich’s research while affiliated with Sidi Mohamed Ben Abdellah University and other places

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Publications (54)


Figure 1: Aerial parts of C. cinerea in flowering stage 2.2. Preparation of C. cinerea extracts 2.2.1. Preparation of CCA by infusion
Figure 3: CCA chromatogram by LC-TOF-MS.
Figure 5: CCE chromatogram by LC-TOF-MS (Phenolic compounds)
Figure 6: Variation in animal body weight over 14 days (dose of 2000 mg/kg).
Phytochemical characterization, acute toxicity and hemolytic activity of Cotula cinerea (Del.) aqueous and ethanolic extracts
  • Article
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September 2024

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132 Reads

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1 Citation

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Elhoussine Derwich

The toxicity of a plant extract is important in the design of medicinal plant-based drugs. A test of the hemolytic effect of a substance on red blood cells (RBC) is an essential starting point. The objective of this study is the phytochemical characterization of the aqueous extract (CCA) and the ethanolic extract (CCE) from the aerial parts of Cotula cinerea (C. cinerea), by LC-TOF-MS, to evaluate their acute toxicity at two different doses (1000 and 2000 mg/kg), and to assess their hemolytic activity against RBC of rat. For the acute toxicity assessment, statistical analysis revealed no significant differences in body weight between treated and control groups over a 14-day period. Liver and kidney weights also showed no significant variation between treated and control groups. Biochemical parameters such as ASAT, ALAT, urea, and creatinine showed similar levels in all groups, with slight variations observed for some parameters. In the hemolytic test, CCE concentrations showed a significantly higher percentage of hemolysis, whereas CCA had no hemolytic effect on RBC of rat. These data suggest the non-toxic effect of CCA, making it suitable for the preparation of medications involved in the treatment of various diseases. However, the CCE exhibits a concentration-dependent hemolytic effect. This underscores the dual nature of plant secondary metabolites. Further research is needed to understand the complex mechanisms behind these effects and to harness the therapeutic potential of plant extracts while mitigating undesirable hemolytic reactions. Citation: Agour, A.; Mssillou, I.; El Abdali, Y.; Bari, A.; Lyoussi, B.; Derwich, E. Phytochemical characterization, acute toxicity, and hemolytic activity of Cotula cinerea (Del.) aqueous and ethanolic extracts.

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Unveiling the molecular composition and biological properties of essential oil derived from the leaves of wild Mentha aquatica L.: A comprehensive in vitro and in silico exploration

July 2024

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220 Reads

The purpose of the current study is to assess the chemical profile, antioxidant, antimicrobial, and insecticide efficacy of essential oil derived from the leaf of Moroccan Mentha aquatica L. (MA-EO) using in vitro and in silico analysis. Using GC-MS/MS analysis, 18 components of MA-EO were identified, including linalool (42.42%), α-elemol (10.45%), α-terpineol (8.07%), linalyl acetate (7.37%), and caryophyllene (4.05%). Additionally, MA-EO has a strong antioxidant capacity with IC50 values of 0.64 ± 0.01 µg/mL using the DPPH assay and 0.167 ± 0.13 µg/mL using the ABTS test. Total antioxidant capacity activities were found to be 188.21 ± 0.31 mg EAA/g, while RP activities were 1.95 ± 0.023. The powerful antibacterial properties of MA-EO were proven to be effective against Escherichia coli and Candida albicans. MA-EO showed insecticidal potential using the fumigation experiment, with an LC50 of 3.33 μL/L in the air after 24 h of exposure. At a dose of 20 µL/mL, MA-EO reduced fertility, fecundity, and emergence of adult C. maculatus. MA-EO had 95% mortality at the same dosage. In silico analysis revealed that the antioxidant activity of MA-EO is linked to γ-eudesmol, while its antibacterial efficacy is associated with phenol, 2,4-di-tert-butyl-, and its antifungal capacity with phenol, 2,4-di-tert-butyl-. MA-EO demonstrates potent bactericidal, fungicidal, and bioinsecticide properties, making it effective for controlling bacteria, fungi, and insect pests in stored grains.


Solvent Polarity Effects on Phenolic Fingerprint and Biological Activities, Using Three Different Extractions Formulation for Examining of Mentha aquatica Leaf Extracts: An In Vitro and In‐Silico Investigation

July 2024

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193 Reads

The main purpose of our research is the evaluation of the efficacity of solvent polarity on phenolic composition, as well as the antibacterial, and antioxidant activities of extract of Moroccan Mentha aquatica L., leaves. To attempt these objectives, the HPLC-DAD was used to identify the biomolecules. The total amount of phenolic and flavonoid content was determined using the Folin-Ciocalteu and aluminum trichloride processes as well as the DPPH, RP, and TAC tests were used to evaluate the antioxidant capabilities. In addition, by employing both in vitro and in silico analysis through the microdilution method, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extracts were assessed against multidrug-resistant bacteria. Furthermore, the High-Performance Liquid Chromatography (HPLC) analysis indicated that all extracts of M. aquatica were abundant in noteworthy phytochemical compounds, especially gallic acid, vanillic acid, chlorobenzoic acid, quercetin, and kaempferol. Furthermore, the results indicated that the total phenolic content was higher in hydroethanolic extract (62.19 ± 1.19 mg GAE/g DW) in contrast to the acetonic and aqueous extracts (22.22 ± 0.64, and 22.44± 0.57 mg GAE/g DW) respectively. Similarly, the aqueous ethanol extract contained the greatest flavonoid concentration, with values of 29.15± 0.09 mg QE/g DW when compared with the other extracts. The seam extract poses excellent antioxidant power with an IC50 of 0.06 ± 0.00 mg/mL for the DPPH test, and lower RP with EC50 of 80± 0.00 µg/ml when compared with acetonic and aqueous extract (370± 0.00 and 460± 0.01 µg/mL) respectively. Moreover, the hydroethanolic extract has a high level of TAC 75.09± 2.00 mg EAA/g DW, followed by aqueous extract carrying a value of 28.53 ± 1.36 mg EAA/g DW. The antibacterial capacity is ranged between 0.78 ± 0.05 mg/mL and 12.60 ± 0.00 mg/L. The results of the in-silico study demonstrated that quercetin, vanillic acid, and naringenin components contribute to the antioxidant capability. While gallic acid, kaempferol, and quercetin components are attributed to the antibacterial capacity.


Coriandrum sativum L., essential oil as a promising source of bioactive compounds with GC/MS, antioxidant, antimicrobial activities: in vitro and in silico predictions

June 2024

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421 Reads

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4 Citations

Introduction: Coriandrum sativum L. essential oil (CS-EO) is being evaluated in vitro for its antioxidant and antimicrobial properties, and its volatile compounds are to be identified as part of this exploratory study. Methods: The processes underlying the in vitro biological properties were explained using in silico simulations, including drug-likeness prediction, molecular docking, and pharmacokinetics (absorption, distribution, metabolism, excretion, and toxicity—ADMET). Chemical screening of CS-EO was conducted using gas chromatography-mass spectrometry (GC-MS). Five in vitro complementary techniques were used to assess the antioxidant activity of CS-EO: reducing power (RP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical scavenging activity, β-Carotene bleaching test (BCBT), and phosphomolybdenum assay (TAC). Results: According to GC-MS analysis, linalool (59.04%), γ-Terpinene (13.02%), and α-Pinene (6.83%) are the main constituents of CS-EO. Based on the in vitro antioxidant assay results, CS-EO has been found to have a superior antioxidant profile. Its estimated scavenging rates for ABTS⁺ are 0.51 ± 0.04 mg/mL, BCBT is 9.02 ± 0.01 mg/mL, and CS-EO is 1.52 ± 0.14 mg/mL. C. sativum demonstrated 6.13 ± 0.00 μg/mL for reducing power and 213.44 ± 0.45 mg AAE/mL for total antioxidant activity. The in vitro antimicrobial activity of CS-EO was assessed against five strains, including two gram-positive bacteria, two gram-negative bacteria, and one fungal strain (Candida albicans). Significant antibacterial and antifungal activities against all strains were found using the disc-diffusion assay, with zones of inhibition larger than 15 mm. The microdilution test highlighted the lowest MIC and MBC values with gram-positive bacteria, ranging from 0.0612 to 0.125% v/v for MIC and 0.125% v/v for MBC. The fungal strain’s MFC was 1.0% v/v and its MIC was measured at 0.5%. Based on the MBC/MIC and MFC/MIC ratios, CS-EO exhibits bactericidal and fungicidal activity. The ADMET study indicates that the primary CS-EO compounds are good candidates for the development of pharmaceutical drugs due to their favorable pharmacokinetic properties. Conclusion: These results point to a potential application of this plant as a natural remedy and offer empirical backing for its traditional uses. It is a promising environmentally friendly preservative that can be used extensively in the food and agricultural industries to prevent aflatoxin contamination and fungal growth in stored goods.


Figure 2. Structures of phytoconstituents of PC-Ext.
Figure 3. Body mass level in the tested groups. The data are presented in the form of mean ± SEM; a comparison between the control group and all groups and b comparison between the PhZ group and remaining groups, *p <0.05, **p <0.01, ***p <0.001.
Figure 4. Percentage erythrocyte osmotic fragility of rats treated with phenylhydrazine or P. crispum, extract, or a combination of the two.
Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

June 2024

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228 Reads

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1 Citation

ACS Omega

Anemia is a widespread global health concern necessitating effective, accessible, and natural interventions. The potential of medicinal plants to address anemia has garnered significant interest. Among these plants, parsley (Petroselinum crispum (Petroselinum crispum) L.) stands out as an edible and herbal-based option for combating anemia. Aim of the study: This study investigated the potential of P. crispum (PC-Ext) as an emerging antianemic product, focusing on its physicochemical attributes, antioxidant properties, and mineral profile. Both qualitative and quantitative analyses of the phenolic compounds in P. crispum were conducted by using high-performance liquid chromatography with a diode array detector (HPLC-DAD). Anemia was induced in rats by intravenous injections of phenylhydrazine, administered at a dose of 40 mg/kg for two consecutive days. The antianemic activity of PC-Ext was assessed at a dose of 500 mg/kg twice daily for 5 weeks by estimating blood parameters, such as serum iron and ferritin. Additionally, the osmotic fragility test measured the capacity of red blood cells to withstand osmotic shock of various concentrations of saline. Aqueous extract of P. crispum was rich in phytochemical compounds, including syringic acid, quercetin, catechin, gallic acid, and luteolin. The findings demonstrate the effectiveness of P. crispum in ameliorating phenylhydrazine-induced reductions in red blood cell count (RBCs), hemoglobin (Hb), and hematocrit (HCT) levels. Consequently, PC-Ext exhibits significant activity against phenylhydrazine-induced anemia in rats, as demonstrated by its ability to prevent hemolysis. Iron estimation within PC-Ext further confirms its utility in addressing both iron deficiency and ferritin-deficiency anemia. Therefore, PC exhibits a favorable effect against both types of anemia, iron deficiency, and hemolysis. The results of this study provide robust scientific validation for ethnomedicinal use and the potential utility of P. crispum, positioning it as a promising source for future pharmaceutical development.


Comparative analysis of Nigella sativa L. oil extraction processes: impacts on chemical composition, antioxidant and antimicrobial properties

June 2024

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166 Reads

This work intended to study differences in oil yield and co-extraction of antioxidant and antibacterial compounds of Nigella sativa L. seed oil as a function of two main extraction processes: mechanical pressing and solvent extraction, including hexane and chloroform. Next, we studied such oils’ chemical composition and antioxidant and antibacterial activities. Notably, the chemical cartelization was conducted by use of HPLC. The antioxidant activity of the oils was assessed using DPPH, TAC, and FRAP assays. Antimicrobial activity was investigated against bacteria and fungi with clinical importanceT. HPLC-DAD analysis identified some bioactive compounds in the oils, including thymoquinone, carvacrol, and gallic acid. Results showed that oils extracted by different methods exhibit varying levels of antioxidant activity, with a higher concentration of antioxidant compounds in chloroform-extracted oils. Antimicrobial tests revealed significant inhibitory effects of the studied oils on the growth of bacteria and fungi. In conclusion, this research has made it possible to characterize the oils extracted from Nigella sativa L. Seeds by determining their chemical composition and biological properties, notably their antioxidant, antibacterial, and antifungal activity. These results contribute to a better understanding of the potential benefits of these oils for human health and open up exciting prospects for their use in various fields, notably as food additives and therapeutic agents.


Phenolic profile, and safety evaluation of the Moroccan aqueous polyherbal formulation containing Petroselinum crispum L., Coriandrum sativum L., Apium graveolens L.: Acute and sub-acute toxicity

May 2024

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183 Reads

South African Journal of Botany

Medicinal plants harbor numerous natural bioactive compounds with therapeutic potential, utilized in the synthesis of various drug formulations. While the diverse benefits of herbal formulations have been extensively researched, a toxicity assessment is crucial to establish a wide margin of safety for the therapeutic application of this polyherbal formulation. The recent study aimed to assess the phytochemical profile and potential toxic effects of an aqueous extract derived from a polyherbal formulation containing Petroselinum crispum L., Coriandrum sativum L., and Apium graveolens L. The investigation involved acute and sub-acute toxicity studies conducted in male and female Swiss albino mice, as well as adult rats. High-performance liquid chromatography analysis revealed a rich composition of phytochemical compounds in the extract. In acute toxicity assessments, oral administration of the extract up to 14 g/kg showed no signs of toxicity or fatalities in mice. However, intraperitoneal administration resulted in dose-dependent toxicity, with a calculated LD 50 of 11.8 g/kg. Sub-acute toxicity studies in rats over 28 days showed no significant changes in organ weights, hematological, or biochemical parameters, except for a minor decrease in WBC count. Histopatho-logical examination revealed no morphological disturbances in the liver and kidneys, indicating a wide margin of safety for therapeutic use.


Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

April 2024

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299 Reads

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12 Citations

Heliyon

This exploratory study aims to identify the volatile compounds in PC-Eo (Petroselinum crispum L. essential oil) and evaluate its antioxidant and antimicrobial properties in vitro. Molecular docking, drug-likeness prediction, and pharmacokinetics (absorption, distribution, metabolism, excretion, and toxicity—ADMET) were among the in silico simulations that were used to explain the biological properties observed in vitro. For PC-Eo's chemical screening, gas chromatography-mass spectrophotometry (GC-MS) was employed. The antioxidant activity of PC-Eo was evaluated using five in vitro complementary techniques, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical scavenging activity, β-Carotene bleaching test (BCBT), reducing power (RP), and phosphomolybdenum assay (TAC). GC-MS analysis revealed that the primary components of PC-Eo are apiol (49.05 %), Myristicin (21.01 %), and 1-allyl-2,3,4,5-tetramethoxybenzene (13.14 %). The results of the in vitro antioxidant assays indicate that PC-Eo exhibits a superior antioxidant profile. The in vitro antimicrobial activity of PC-Eo was assessed against five strains, including 2 g-positive bacteria, 2 g-negative bacteria, and one fungal strain (Candida albicans). The disc-diffusion assay revealed significant antibacterial and antifungal activities against all strains, with zones of inhibition exceeding 15 mm. The microdilution test highlighted the lowest MIC and MBC values with gram-positive bacteria, ranging from 0.25 to 0.5 % v/v for MIC and 0.5–1.0 % v/v for MBC. For the fungal strain, MIC was recorded at 1.25 % and MFC at 2.5 % v/v. PC-Eo demonstrates bactericidal and fungicidal activity based on the MBC/MIC and MFC/MIC ratios. According to the ADMET study, the primary PC-Eo compounds have advantageous pharmacokinetic characteristics. These findings provide empirical support for the traditional uses of this plant and indicate its possible use as a natural remedy.



Fig. 1. Some existing mechanisms for possible aphrodisiac effects of the Apiaceae polyherbal formulation.
Compounds present in P. crispum, C. sativum, and A. graveolens with aphrodisiac activity according to the literature.
Sexual Behavior (mean ± SEM) for males after administration of the ethanolic extract of parsley, coriander, celery, and the mixture at dose 250 mg / kg.BW.
Rekindling desire: Unveiling the Aphrodisiac potential of Apiaceae Elixirs

February 2024

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251 Reads

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4 Citations

Phytomedicine Plus

Background: In the realms of herbal pharmacology, the Apiaceae family has long held the torch, with parsley, coriander, and celery at the forefront. They have been extensively utilized in traditional therapies, including their use as aphrodisiacs. The primary objective of this study was to evaluate the aphrodisiac potential of three Apiaceae plants: Petroselinum crispum, Coriandrum sativum, and Apium graveolens, both individually and in combination, to substantiate their traditional medicinal usage. Methods: The administration of extracts orally (at a dose of 250 mg/kg of body weight) was carried out daily for 15 days in various groups of male rats. To induce receptivity in female rats used for mating, hormonal treatment was employed. The study encompassed the assessment of general mating behavior, which was compared to that induced by the standard reference drug, sildenafil citrate. Additionally, hematological and biochemical assays were conducted. Results: The results of this study demonstrated that oral administration of the extracts at a dose of 250 mg/kg significantly heightened sexual activity in male rats. This was characterized by a substantial increase in parameters such as mounting frequency, erection frequency, ejaculation frequency, and copulatory rate, coupled with a noteworthy reduction in mounting latency, intromission latency, and latency time. However, when compared to the positive control group (sildenafil), the polyherbal formulation did not induce significant alterations in hematological parameters such as red blood cell count, white blood cell count, blood platelet count, and hemoglobin levels. Furthermore, the hepatic and renal markers in treated rats displayed no significant disturbances when administered with the individual extracts of the three Apiaceae plants or in combination, in comparison to the control group. The results also unveiled a substantial augmentation effect in blood testosterone levels following the individual administration of Apiaceae plant extracts when compared to the positive control group. The combined administration of these extracts at a dose of 250 mg/kg exhibited an even more pronounced effect in enhancing testosterone levels than administering the individual extracts. Conclusions: In conclusion, the polyherbal formulation comprising these Apiaceae plants demonstrated a substantial and sustained enhancement in the sexual activity of healthy male rats, without any discernible adverse effects. This suggests that the formulation maintains aphrodisiac properties, possibly attributed to its nerve-stimulating effects, thereby enhancing libido and potency. These findings not only support the traditional use of these herbs for their aphrodisiac properties but also propose potential applications for human use as a natural alternative for addressing male sexual disorders and as aphrodisiac agents.


Citations (44)


... Initially, pkCSM and SwissADME servers were properly used to predict 11 chemical compounds' physicochemical properties and absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics (El fadili et al., 2023a, El fadili et al., 2023bAbechi et al., 2024;Errahmani et al., 2024;Nouioura et al., 2024e). Second, AutoDock software was equally used to explore the inhibition mechanism with corresponding binding energies in kcal/mol (Nouioura et al., 2024a;Nouioura et al., 2024d;Nouioura et al., 2024c), in which the targeted protein coded in the protein data bank by 2CDU.pdb was prepared by adding the Gasteiger charges and removing all suspended ligands bound to the targeted protein (El fadili et al., 2022b, El fadili et al., 2022a, El fadili et al., 2023c. Finally, Discovery Studio 2021 software was also employed to visualize the produced intermolecular interactions in two and three dimensions (Bouzammit et al., 2024c;Bouzammit et al., 2024b;Bouzammit et al., 2024a). ...

Reference:

Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations
Coriandrum sativum L., essential oil as a promising source of bioactive compounds with GC/MS, antioxidant, antimicrobial activities: in vitro and in silico predictions

... The latest studies on A. patinoi are concerned with the integration of the fruit into the food industry through the development of food products such as pastries, drinks, and confections, and with the aphrodisiac reputation of the fruit. A. patinoi latest studies are concerned with the integration of the fruit into the food industry through the development of food products such as pastries, drinks, and confections [20,138,139]. B. gasipaes, the most studied of the five species, is the subject of research on resistance to climate change, biofilm production, use of its starch in the production of aerogel, and other sustainable applications of a resource with waste that can be turned into new products [19,140,141]. E. stipitata garners interest for its phenolic compounds and essential oil, with research in microparticles, the insecticidal activity of its oil, and cultivation of the species [142][143][144]. ...

Rekindling desire: Unveiling the Aphrodisiac potential of Apiaceae Elixirs

Phytomedicine Plus

... Initially, pkCSM and SwissADME servers were properly used to predict 11 chemical compounds' physicochemical properties and absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics (El fadili et al., 2023a, El fadili et al., 2023bAbechi et al., 2024;Errahmani et al., 2024;Nouioura et al., 2024e). Second, AutoDock software was equally used to explore the inhibition mechanism with corresponding binding energies in kcal/mol (Nouioura et al., 2024a;Nouioura et al., 2024d;Nouioura et al., 2024c), in which the targeted protein coded in the protein data bank by 2CDU.pdb was prepared by adding the Gasteiger charges and removing all suspended ligands bound to the targeted protein (El fadili et al., 2022b, El fadili et al., 2022a, El fadili et al., 2023c. Finally, Discovery Studio 2021 software was also employed to visualize the produced intermolecular interactions in two and three dimensions (Bouzammit et al., 2024c;Bouzammit et al., 2024b;Bouzammit et al., 2024a). ...

Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

Heliyon

... In the present work, the chemical composition of Ferula communis leaf was examined using in silico predictions of physicochemical and ADME-Tox pharmacokinetic features, followed by the molecular docking simulation for p-hydroxybenzoic acid (M8) as the major compound of the studied extract, which was complexed to NADPH oxidase protein to explore the chemical interactions mode that could provide a rationale for the antioxidant activity of Ferula communis leaf (Assaggaf et al., 2023;Benkhaira et al., 2023;Jeddi et al., 2023). Initially, pkCSM and SwissADME servers were properly used to predict 11 chemical compounds' physicochemical properties and absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics (El fadili et al., 2023a, El fadili et al., 2023bAbechi et al., 2024;Errahmani et al., 2024;Nouioura et al., 2024e). Second, AutoDock software was equally used to explore the inhibition mechanism with corresponding binding energies in kcal/mol (Nouioura et al., 2024a;Nouioura et al., 2024d;Nouioura et al., 2024c), in which the targeted protein coded in the protein data bank by 2CDU.pdb was prepared by adding the Gasteiger charges and removing all suspended ligands bound to the targeted protein (El fadili et al., 2022b, El fadili et al., 2022a, El fadili et al., 2023c. ...

Exploring the essence of celery seed: Innovations in microwave-assisted hydrodistillation for essential oil extraction using in vitro, in vivo and in silico studies

Arabian Journal of Chemistry

... Morocco, ranked, in 2023, as number one in peppermint and spearmint-producing countries [7], benefits from its remarkable plant diversity, allowing the development of a rich tradition of using aromatic and medicinal plants both in cuisine and for health benefits [8,9]. Among these plants, the genus Mentha is essentially represented by seven species that hold a unique position in Moroccan cultural practices and traditional medicine, showcasing an extensive range of applications [5,10,11]. ...

Phenolic profile, acute and subacute oral toxicity of the aqueous extract from Moroccan Mentha longifolia L. aerial part in Swiss Albino mice model
  • Citing Article
  • January 2024

Journal of Ethnopharmacology

... Hydrogen atoms were introduced, and hydroxyl groups, water molecules, and amino acids were rearranged to correct structural defects such as atom overlap or absence. The proteins were subsequently modified in a delicate manner to enhance their structural characteristics Lafraxo et al., 2022;Tourabi et al., 2023). ...

Antioxidant, Antimicrobial, and Insecticidal Properties of Chemically Characterized Essential Oils Extracted from Mentha longifolia: In Vitro and In Silico Analysis

Plants

... Flavonoids, phenols, and tannins were the common secondary metabolites that were not detected in the petroleum ether crude extract. The results were in agreement with other reports where relatively polar solvents often extracted the aforementioned phytochemicals abundantly from the leaves of MPs [32,33]. ...

Efficacy of various extracting solvents on phytochemical composition, and biological properties of Mentha longifolia L. leaf extracts

... Thin and fragile alveolar septum or thickening of the alveolar wall was observed in some regions. These histological findings are in agreement with the results of in vivo experiments using extracts of P. crispum and C. tamala to mitigate liver and kidney toxicity [46,47]. ...

The Protective Potential of Petroselinum crispum (Mill.) Fuss. on Paracetamol-Induced Hepatio-Renal Toxicity and Antiproteinuric Effect: A Biochemical, Hematological, and Histopathological Study

Medicina

... Plants contain various potentially toxic compounds that, once absorbed, tend to accumulate in the liver, a key detoxification organ (Saad et al., 2006;Zouirech et al., 2023). Indeed, the liver plays an essential role in metabolizing foreign substances, sometimes converting them into potentially hepatotoxic compounds (Moselhy & Ali, 2009;Perveen et al., 2017). ...

Prefatory in silico studies and in vitro insecticidal effect of Nigella sativa (L.) essential oil and its active compound (carvacrol) against the Callosobruchus maculatus adults (Fab), a major pest of chickpea

... This diversification of use is attributed to the presence of beneficial bioactive molecules that can be harnessed across various sectors [4]. Due to their wide spectrum of bioactivities against diseases and parasites, plant-based essential oils (EOs) have recently attracted a lot of interest [5][6][7]. This suggests that they could be used in place of synthetic pesticides and antibiotics in situations involving crop protection and other pest control. ...

Pharmacological activities of chemically characterized essential oils from Haplophyllum tuberculatum (Forssk.)