Eleni Papakonstantinou’s research while affiliated with University of Freiburg and other places

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Publications (188)


Exploring the Role of WISP1 in Redox Homeostasis in COPD
  • Conference Paper

October 2024

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4 Reads

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Eleni Papakonstantinou

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Citations (32)


... For example, HLA molecules play a role in antigen presentation in immune responses; depending on HLA types, these molecules may be upregulated in autoimmune diseases [74]. Such overactivation could well account for the worldwide increase in the expression of genes associated with immune response, cell migration, and tissue remodeling [75]. ...

Reference:

Identifying Biomarkers for Rheumatoid Arthritis and Spondyloarthritis by Machine Learning
WISP1 and Macrophage Migration Inhibitory Factor in Respiratory Inflammation: Novel Insights and Therapeutic Potentials for Asthma and COPD
  • Citing Article
  • Full-text available
  • September 2024

International Journal of Molecular Sciences

... Other profibrotic-related genes directly modulated by WISP1 included growth factors (VEGFA, EGFR, NEGF, FGF2, FLT1/VEGFR1, CCN2), cellular hypoxia inducible factors (HIF1A, HIF3A), cellular adhesion molecules (VCAM1, ICAM1), and serine protease inhibitor family members (SERPINE1, SERPINH1) (Table S3). A recent study showed that WISP1 phosphorylates and activates EGFR to activate MIF, which, in turn, drives lung inflammation and remodeling [40]. ...

WISP1 induces the expression of macrophage migration inhibitory factor (MIF) in human lung fibroblasts through Src kinases and EGFR-activated signaling pathways
  • Citing Article
  • December 2023

AJP Cell Physiology

... LRG6 was upregulated in epithelial progenitors and may contribute to senescence in fibrotic areas of lung tissue in COPD patients [43]. Other polymorphisms are associated with clinically relevant outcomes such as responsiveness to triple therapy (FKBP5) and early onset of COPD (Hedgehog pathway) [44,45]. Bulk RNA sequencing and proteomics analysis of broncho alveolar lavage (BAL) revealed associations between dysregulated iron metabolism and neutrophilic inflammation in COPD [46]. ...

FKBP5 rs4713916: A potential genetic predictor of differential response to triple therapy among COPD patients
  • Citing Conference Paper
  • October 2023

... Bulk RNA sequencing and proteomics analysis of broncho alveolar lavage (BAL) revealed associations between dysregulated iron metabolism and neutrophilic inflammation in COPD [46]. Polymorphisms in the iron regulatory gene, IREB2, were also shown to be associated with decreased FEV1 and diffusing capacity of the lungs for carbon monoxide (DLCO) percentage of predicted [47]. MicroRNA (miR)-149-3p was shown to be a key regulator of cellular senescence induced by cigarette smoke [48]. ...

Genetic variants in the Iron responsive element binding protein 2 (IREB2) are associated with spirometry parameters and cough prevalence
  • Citing Conference Paper
  • October 2023

... fractional nitric oxide (FeNO) levels in patients with COPD 11 . Thus, potential impact of SEs sensitization on the pathophysiology of COPD remains unclear at present. ...

Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease

Respiratory Research

... Smooth muscle hypertrophy has also been observed in the large and small airways of COPD patients. Interestingly, COPD patients with greater airway smooth muscle area (>20% of bronchial biopsy area) have greater improvements in lung function following ICS treatment for 12 months, compared to patients with smooth muscle area <20% [35]. The T2 cytokine IL-13 promotes both smooth muscle proliferation and contractility in asthma [36], and perhaps the COPD findings represent suppression of IL-13-related mechanisms by ICS. ...

Airway smooth muscle area to predict steroid responsiveness in COPD patients receiving triple therapy (HISTORIC): a randomised, placebo-controlled, double-blind, investigator-initiated trial
  • Citing Article
  • June 2023

European Respiratory Journal

... Patients diagnosed with COPD frequently present with comorbidities necessitating the administration of multiple medications, thereby increasing the potential for drug interactions and consequent adverse effects [71]. The utilization of a range of inhalers encompassing diverse medication classes provides healthcare providers with the opportunity to rationalize treatment protocols, thereby reducing the necessity for supplementary systemic medications and mitigating the likelihood of side effects associated with polypharmacy. ...

Current and future developments in the pharmacology of asthma and COPD: ERS seminar, Naples 2022

Breathe

... MMP-1 and MMP-14 are both associated with atherosclerosis and MMP-1 was found increased in heart failure patients and associated with arterial hypertension [71,76]. Similarly, MMP-1 and MMP-14 are increased in idiopathic pulmonary fibrosis, they are involved in chronic obstructive pulmonary disease (COPD), and they can be induced by smoking and are associated with early-onset of lung cancer [77][78][79][80][81]. ...

Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease

International Journal of Molecular Sciences

... A current area of interest and active research is the use of neutrophil-to-lymphocyte ratio as a marker of outcomes in COPD, including exacerbations and mortality [148][149][150]. Measurement of fractional exhaled nitric oxide (FeNO) over time has been proposed as a prognostic indicator of individual patient risk in COPD [151], based on its association with IL-13 and exacerbations [152][153][154]. However, further study is needed before a 'FeNOtyping' approach can be applied in practice [151].There are currently limited applications for biomarkers in COPD diagnosis or prognosis. ...

Variability of fractional exhaled nitric oxide is associated with the risk and aetiology of COPD exacerbations
  • Citing Article
  • December 2022

Respirology

... в постковидном периоде составила 39 и 47%, при этом отмечалась значимость тяжести перенесенной COVID-19, как фактора риска функциональных нарушений [19]. Вероятность снижения DL CO < 80% у пациентов, перенесших тяжелую COVID-19, возрастает практически в два раза по сравнению с пациентами, перенесших заболевание в нетяжелой форме (отношение шансов (ОШ) -1,82; 95%-ный доверительный интервал (ДИ) -1,32-2,50) [12]. Помимо тяжести заболевания, описаны и другие факторы, предрасполагающие к снижению Dl CO в отдаленном от острых симптомов периоде [20]. ...

The Role of Atopy in COPD and Asthma