Ekrem Kaya’s research while affiliated with Bursa Uludağ Üni̇versi̇tesi̇ and other places

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Publications (3)


Two Cases With Developing Neurologic Complications After Liver Transplant
  • Article
  • Full-text available

December 2015

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120 Reads

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4 Citations

Experimental and clinical transplantation: official journal of the Middle East Society for Organ Transplantation

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Ekrem Kaya

The widespread use of immunosuppressive agents has significantly increased the rates of successful solid-organ and stem cell transplants, especially with liver and kidney. Cyclosporine and tacrolimus are most commonly used for this purpose. Although these agents have different mechanisms of action, both have various adverse effects, including nausea, vomiting, headache, hypertension, nephrotoxicity, and rarely epileptic seizures. In our first case, a patient presented with epileptic seizures and hemiparesis after a liver transplant, and posterior reversible encephalopathy syndrome related to cyclosporine toxicity was considered. Once cyclosporine levels in the blood decreased, the patient had both clinical and radiologic improvements. In our second case, a patient presented with delirium after a liver transplant. Again, when cyclosporine levels in the blood decreased, the patient showed improvement in clinical findings. Neurologic complications may develop after liver transplant, and these complications are encountered most frequently within the first postoperative month. Neurologic complications are multifactorial; insufficient graft function, intracranial bleeding, cerebral infarcts, infections, and immunosuppressive drug toxicity (tacrolimus and cyclosporine) may be considered among these factors. As shown in our presented cases, most neurologic complications can be successfully treated by correcting the underlying factor.

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Successful emergency endovascular treatment of iatrogenic giant hepatic artery pseudoaneurysm

July 2014

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17 Reads

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4 Citations

Visceral artery aneurysms and visceral artery pseudoaneurysms frequently present as life-threatening emergencies. Hepatic artery pseudoaneurysm (HAP) is a very rare disease but in cases of complication, there is a very high mortality. The most common cause of HAP is iatrogenic trauma such as liver biopsy, transhepatic biliary drainage and cholecystectomy. We present a case of hepatic artery pseudoaneurysm presenting as hemobilia managed with cover stent of the aneurysm. Hepatic artery, Visceral aneurysm, Visceral pseudo-aneurism.

Citations (2)


... Thus, we believe our data contributed to present knowledge by revealing effective doses of tacrolimus for seizure control in a preclinical acute seizure model. Occasionally, clinical case reports show seizure development after tacrolimus therapy in organ transplant patients [53][54][55][56][57]. ...

Reference:

Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats
Two Cases With Developing Neurologic Complications After Liver Transplant

Experimental and clinical transplantation: official journal of the Middle East Society for Organ Transplantation

... Arterial access was obtained in the majority of the cases through the femoral artery (58.5%), followed by the left brachial artery (9.7%), while in 13 cases (31.7%), vascular access was not reported. Fifteen patients (36.6%) were treated using stent grafts and closed-cell and double-layer micromesh stent [8,11,12,14,16,19,21,24,25,30,31,34,36,42,43]. Ten patients were treated exclusively by coils (24.4%) [10,13,17,23,26,27,29,32,37,44], but in most cases, a combination of endovascular methods was used (liquid embolic agent+vascular plug [22,42], coils+vascular plug [15,33,35], covered stents+coils [38,39], coils+liquid embolic agent [28,40], coils+vascular plug+peripheral occlusion device [42]). ...

Successful emergency endovascular treatment of iatrogenic giant hepatic artery pseudoaneurysm
  • Citing Article
  • July 2014