Edward J. Parish’s research while affiliated with Auburn University and other places

... The use of plant-based lipid sources to replace FO in aquaculture feeds results in reduced dietary cholesterol content, because they contain high levels of phytosterols and very little cholesterol compared to fish oils (Norambuena et al., 2013). Cholesterol is an integral component of cell membranes and serves as a precursor to important metabolites, such as sterol hormones and bile acids (Thomas et al., 2012; Parish et al., 2008; Norambuena et al., 2013). Most of the significant correlations among cholesterol-related genes with dietary and muscle tissue sterol and FA content were related to cholesterol catabolism or reduced cholesterol synthesis. ...

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Growth performance, tissue composition, and gene expression responses in Atlantic salmon (Salmo salar) fed varying levels of different lipid sources

... Further work on the synthesis of steroid 5,6-epoxides from olefins using KMnO 4 /metal sulphate and nitrate systems has been published [40] and two mechanistic approaches have been proposed for this reaction. Parish and Li suggested that there was coordination of the copper ion on the less hindered -face of the double bond, forming a -complex that weakened it and provided for the subsequent permanganate attack on the -face [41,42]. Another study, however, suggested that the mechanism involved the kinetically controlled attack of the MnO 4 − ion in the omega phase on the alkene, in a Markovnikoff manner and in an axial sense. ...

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One-pot, high yield synthesis of α-ketols from Δ5- steroids

... It was significant that under the solvent-free conditions 3-acetoxy cholesterol (11) was typically oxidized by PFC to 3-acetoxy-7-ketocholesterol (11a) in 64% isolated yield in about 2 hr at 658C. Incidentally, although oxidation of D 5 -steroids in refluxing benzene with PFC was quite effective, [20] a similar oxidation in CH 2 Cl 2 or CH 3 CN under prolonged reflux did not afford any promising results. [9] The efficacy of the protocol is demonstrated also by the alacrity with which the deoximation of 12 to the corresponding ketone (12a) occurred. ...

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The economic synthesis of pyridinium fluorochromate(VI), C5H5NH[CrO3F] (PFC), and solvent-free oxidation of organic substrates with PFC

... They usually contain very long-chain fatty acids, primary and secondary alcohols, hydrocarbons, sterol esters, aliphatic aldehydes, ketones, b-diketones, triacylglycerols, triterpenes, and sterols. Genetic and environmental factors influence the quality of waxes and the structure (chain length, degree of unsaturation, and branching) of the substances in their composition (Parish et al. 2002;Tinto et al. 2017). Animal sources of waxes include insects (bees, Apis mellifera), whales (Physeter macrocephalus), and sheep (Ovis aries) (Tinto et al. 2017). ...

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An alternative source of medicines: pharmaceutical utilization of animal-derived metabolites

... The authors have cited additional references within the Supporting Information. [66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81] ...

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A Simplified Approach for Electrochemical Allylic Oxidation of Olefins

... Labile tetrakis-acetonitrile complexes of the [Cu(CH 3 CN) 4 ]X type, where X ¼ BF 4 À , PF 6 À , ClO 4 À (ref. 1 and 2) are widely used in research laboratories and industrial processes as catalysts in cycloaddition 3,4 and Ullmann 5 reactions, intramolecular aromatic annulations, 6,7 oxidation of primary alcohols 8 and many other popular reactions of organic synthesis. [9][10][11][12][13] At the same time they serve as important precursors for the synthesis of overwhelming majority of mononuclear [14][15][16] and homo-17 and hetero-polynuclear 18,19 copper(I) complexes, which also have numerous practical applications, [20][21][22] one of which is large-scale production of emitting materials for OLED fabrication. ...

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Efficient one-pot green synthesis of tetrakis(acetonitrile)copper( i ) complex in aqueous media

... 相比 [15] , 配合物1~5具有近似的量子产率和寿命(表4). [38,39] . 因此, 太赫兹光谱是一种用来区别和确定有机- ...

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Structures and photophysical properties of copper(I) complexes bearing 1,10-phenanthroline and 1,3-bis(diphenylphosphino)propane

... The response is reversible when cycled at 1-min exposure to Cl 2 followed by the 1-min N 2 cleaning. The EuPc 2 -based amperometric sensor may be considered to be selective to Cl 2 in light of the observation that there is no change in conductivity on exposure to ammonia (NH 3 ), nitric oxide (NO) and NO 2 [35]. The 5-100 ppm NO 2 sensing response of evaporated cobalt phthalocyanine films (35-80 nm thick) on Au-interdigitated electrodes has been investigated by recording current at a constant bias of 1 V. Like the LB phthalocyanine films, the kinetic responses over 100 min are characterised by initially rapid surface adsorption, and subsequently, slow diffusion into the bulk and the complete recovery is, therefore, not achieved [36]. ...

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Phthalocyanines as Sensitive Materials for Chemical Sensors

... Authentic samples of 3P-hydroxy-5a-cholest-8(14)-en- 15-one (1) (l), 3a-hydroxy-5a-cholest-8(14)-en-15-one (13), 5a-cholest-8(14)-en-15-one (14), 5a-cholest-8(14)-ene-3,15dione (15), 3fl-hydroxy-5a-cholesta-6,8(14)-dien-l5-one (16), 5a-cholesta-6,8(14)-diene-3,15-dione (16), and [ 2,2,3a,4,4-*HI-1 (15) were prepared as described previously. [4-14C]-1, a gift from Lederle Laboratories (Pearl River, NY), was purified as described previously (lo). ...

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Inhibitors of sterol synthesis. Characterization of trimethylsilyl dienol ethers of 3β-hydroxy-5α-cholest-8(14)-en-15-one. Applications in the analysis of mitochondrial metabolites of the 15-ketosterol by gas chromatography-mass spectrometry

... Gas-liquid chromatography (GLC) was performed with flame ionization detection using a 15-30 m DB-5 capillary column (0.25 mm ID, 0.10 pm film thickness, 5 psi N,). High performance liquid chromatography (HPLC) was performed on a Spherisorb ODS-I1 column (C,,, 5 Houston, TX) using a Waters instrument (Model 6000 pump, U6K injector, and either a Model R401 refractive index detector or Model 490 UV detector; Milford, MA). Elemental analyses were performed by Galbraith Laboratories (Knoxville, TN). ...

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Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells