Eduardo Antonio Chelin Suárez’s research while affiliated with São Paulo State University and other places

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Publications (4)


Tratamento periodontal e reabilitador em paciente com fibroma ossificante periférico em área estética: relato de caso, com acompanhamento de cinco anos
  • Article

May 2024

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7 Reads

Brazilian Journal of Periodontology

Letícia Cavassini Torquato

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Clarissa Carvalho Martins Maciel

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Nátaly Domingues Almeida

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[...]

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INTRODUÇÃO: O fibroma ossificante periférico (FOP) é uma lesão não neoplásica de crescimento lento, que se origina a partir de células do ligamento periodontal ou do periósteo, sua etiologia ainda é desconhecida. OBJETIVO: Este relato de caso tem como objetivo demonstrar o tratamento periodontal, bem como a reabilitação com implante, e o acompanhamento de uma paciente diagnosticada com FOP na região anterior de maxila. RELATO DE CASO: Paciente do sexo feminino, 53 anos de idade, procurou atendimento devido à presença de lesão, mobilidade e extrusão do dente #21. Além disso, a paciente foi diagnosticada com periodontite estágio III generalizada grau B, passou por terapia periodontal e optou por realizar exodontia do dente #21, em conjunto com a biópsia excisional da lesão apresentada. Durante a biópsia, além da lesão de tecido mole, foram removidos periósteo e exostose óssea subjacentes à lesão. O laudo confirmou diagnóstico de processo proliferativo não neoplásico na forma de FOP. Após dois anos de acompanhamento de recidiva ou não da lesão, a paciente passou por tratamento reabilitador com implante. CONCLUSÃO: O presente relato demonstra um caso clínico de sucesso, no qual uma paciente diagnosticada com um processo proliferativo não neoplásico conseguiu seguir para tratamento reabilitador sem recidivas, ao ter a lesão e fatores irritativos locais devidamente removidos. A paciente continua a ter sua condição bucal acompanhada anualmente e não apresenta qualquer sinal de recidiva da lesão. PALAVRAS-CHAVE: Fibroma ossificante. Periodontite. Implantação dentária. Biópsia.


Contact angle of NACFF and ACFT samples and swelling test graphics. Wettability test: (A) NACFF sample in Attension software; (B) ACFT sample in Attention software. Swelling test: (C) swelling rate for the PBS solution. Statistical significant difference with Ag‐ACFF (*), statistical significant difference with ACFF (#); (D) swelling rate for the water solution. Statistical significant difference with Ag‐ACFF (*). Ag‐ACFF showed the highest percentage of absorption for the two solutions. p < .001‐two‐way ANOVA followed by Tukey's Test.
Subcutaneous implants of all groups in 7 days (2.5×).
Subcutaneous implants of all groups in 21 days (2.5×). In ACFF 21d, it is possible to observe the process of phagocytosis. In the ACFT 21d greater presence of giant cells.
Picrosirius red analysis, showing collagen fibers. (A) Picrosirius red analysis, Ag‐ACFF group 7d (2.5×). It is possible to check greenish collagen fibers, located on the edge of the capsule that surrounds the implant. (B) At 21 days (2.5×), greater predominance of red fibers. (C) ACFT 7d (2.5×) greater presence of type III green fibers, in the period of 7 days. (D) In 21 days permanence of type III fibers.
Quantitative analysis of collagen fibers by picrosirius red staining. Only the groups NACFF and ACFF showed a statistically significant difference for the presence of collagen fibers in the period of 7 days. Two‐way ANOVA followed by Tukey's test.

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Carbon fiber: Characterization and evaluation of the inflammatory response and toxicity in rats
  • Article
  • Publisher preview available

July 2023

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83 Reads

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1 Citation

Journal of Biomedical Materials Research Part B Applied Biomaterials

This study aimed to evaluate the Carbon Fiber obtained from PAN textile and cotton fiber in their different forms of presentation: non‐activated carbon fiber felt (NACFF), activated carbon fiber felt (ACFF), silver activated carbon fiber felt (Ag‐ACFF), and activated carbon fiber tissue (ACFT), to obtain scaffolds as a potential material with properties related to the synthetic bone graft. Characterization tests performed: surface wettability, traction, swelling, and in vivo tests: evaluation of the inflammatory response by implanting the materials in the subcutaneous tissue of 14 Wistar rats, evaluation of collagen fibers by picrosirius red staining and assessment of toxicity in the following organs: heart, spleen, liver, and kidney. In the wettability test, NACFF and ACFT were hydrophobic (θ124° and 114°), ACFF and Ag‐ACFF were hydrophilic. For maximum stress, ACFF was more resistant (2.983 ± 1.059) p < .05. In the swelling test, the Ag‐ACFF and ACFF groups showed the highest absorption percentage for the PBS solution and distilled water (p < .001). The organs showed no signs of acute systemic toxicity. The implant regions showed mild to moderate inflammatory infiltrate at 7 and 21 days. Only the ACFT group did not show the maturation of type I collagen fibers in 21 days. Through the conducted analyses, the ACFT shows little potential to be indicated as a possible scaffold. Therefore NACFF, ACFF, and Ag‐ACFF have the potential to be considered scaffolds due to the following characteristics presented: good absorption rate, hydrophilicity, and non‐toxic.

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Bone repair assessment of critical size defects in rats treated with mineralized bovine bone (Bio-Oss®) and photobiomodulation therapy: a histomorphometric and immunohistochemical study

September 2021

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57 Reads

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12 Citations

Lasers in Medical Science

This study aimed to investigate the effects of administering photobiomodulation therapy (PBM) with bovine bone matrix on critical size defects in rats. Seventy-two adult male rats (albinus, Wistar), 90 days old, were used. Defect of 5 mm in diameter was made in their calvaria. The animals were divided into 4 groups: C-blood clot, B-Bio-Oss®, L-PBM, B+L-Bio-Oss®+PBM. Each group has been subdivided into 07, 30, and 60 days of observation. For PBM, a low GaAlAs energy of 660 nm was irradiated, total energy density of 45 J/cm2 . PBM was conducted in a trans-surgical form once only. For immunohistochemistry, a semi-quantitative analysis was made of expression of osteoprotegerin (OPG), nuclear kappa B-factor ligand receptor activator (RANKL), and tartrate-resistant acid phosphatase (TRAP). All histomorphometric data were statistically analyzed by ANOVA and Tukey test, significance level of 5%. The groups that showed the highest proportion of neoformation were L (0.39% ± 0.13) and C (0.37% ± 0.97), but groups B and B+L had larger defect size (C-1.75 mm2 ± 0.40, B-3.02 mm2 ± 0.63, L-2.45 mm2 ± 0.53, B+L-3.23 mm2 ± 1.01). In immunohistochemistry, groups B and B+L had higher immunostaining scores for OPG and RANKL at 60 days, and TRAP immunostaining increased in all groups at 30 days, but group L was the only one to present specimens with score 0. Although, at 60 days, groups L and C presented the highest proportion of bone neoformation, at 30 days group B+L had more than twice as much bone neoformation as group B, the choice of treatment application should depend on the aim of the treatment.


Citations (1)


... To investigate the osteogenic potential of the PGBT in vivo, we established a rat cranial defect model. Previous studies have suggested that full-thickness cranial defects with a diameter greater than 5 mm are considered critical-sized defects [57], where the animal's self-repair ability is limited, effectively reflecting the osteogenic potential of the material. Therefore, we prepared a 6 mm diameter circular full-thickness cranial defect model and included an LIPUS group (Fig. 3B). ...

Reference:

A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties
Bone repair assessment of critical size defects in rats treated with mineralized bovine bone (Bio-Oss®) and photobiomodulation therapy: a histomorphometric and immunohistochemical study

Lasers in Medical Science