Edison K. Miyawaki's research while affiliated with Harvard Medical School and other places
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Publications (10)
Is the cerebrum involved in its own activation to states of attention or arousal? “Telencephalon” is a term borrowed from embryology to identify not only the cerebral hemispheres of the forebrain, but also the basal forebrain. We review a generally undercited literature that describes nucleus basalis of Meynert, located within the substantia innomi...
The association between idiopathic Parkinson's disease, a paradigmatic dopamine-deficiency syndrome, and problems in the estimation of time has been studied experimentally for decades. I review that literature, which raises a question about whether and if dopamine deficiency relates not only to the motor slowness that is an objective and cardinal p...
We describe an acute, postoperative dysarthria-facial paresis. While the rare stroke syndrome has been described previously, we present an under-described clinical nuance to its presentation with a particularly clear imaging correlation. A 78-year-old, right-handed man with a past medical history of aortic stenosis presented after a transcatheter a...
Background and Purpose
Fibrosing inflammatory pseudotumor (FIP) of the nasopharynx is a rare nonneoplastic inflammatory lesion that is frequently mistaken for malignancy or infection. It is often misdiagnosed by radiologists as nasopharyngeal carcinoma or lymphoma, resulting in multiple biopsies and delays in diagnosis. The purpose is to understand...
Clasmatodendrosis derives from the Greek for fragment (klasma), tree (dendron), and condition (- osis). Cajal first used the term in 1913: he observed disintegration of the distal cell processes of astrocytes, along with a fragmentation or beading of proximal processes closer to the astrocyte cell body. In contemporary clinical and experimental rep...
We report two cases of biopsy-corroborated “fibrosing inflammatory pseudotumor” to illustrate that the entity, rarely described in the neurological literature, should be included in the differential diagnosis of either a cranial mononeuropathy or, certainly, in the case of progressive cranial neuropathies. A broad differential diagnosis arises in c...
Citations
... Another recent review highlights the importance of time perception, and directly related with it dopaminergic neuronal firing in very short time intervals, and motor behaviours. Knowing how to affect dopamine neurons (subjective time perception), may be critical in Parkinson's disease treatment [4]. ...
... In AD, rather than observing an increase in the number of astrocytes, these cells face alterations in morphology (hypertrophy and increased number of their main processes [17] and biochemical properties: varying levels of GFAP expression, different orientation of processes toward or into Aβ deposits, degeneration or clasmatodendrosis) [20]. The latter has been observed mostly in fibrous astrocytes [17] and is the disintegration both of the distal cell processes of astrocytes, and of the proximal ones, closer to the astrocyte cell body [23]. Despite the numerous studies carried out in this regard, the mechanisms for which we find the astrocytes "embraced" with the Aβ plaques are not yet completely defined. ...
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