E.S. Hirata's scientific contributions

Citations

... However, hormonal changes might also be involved in such structural and ultrastructural lesions. Hirata and Hirata (1991) showed that the increase in acetate alters fatty acid metabolism by inhibiting lipolysis, thereby contributing to the formation of hepatic steatosis. The accumulation of fatty acids promotes increased concentration of acetate in the liver, promoting its release into blood plasma, which can be degraded to obtain energy or even accumulated in the form of fatty acids and cholesterol in extra-hepatic tissues. ...