E U Bieler’s research while affiliated with Deutsche Klinik für Diagnostik, Wiesbaden and other places

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Publications (18)


[Single photon emission computed tomography of patients with benign and malignant spinal diseases].
  • Article

September 1986

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5 Reads

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4 Citations

RöFo - Fortschritte auf dem Gebiet der R

E U Bieler

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K Fox

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P Pfannenstiel

SPECT has been used in a comparative study with planar bone scintigraphy in 54 patients. Spatial resolution of the method is sufficient to localise the vertebral bodies, the spinous processes, the intervertebral, costotransverse and costovertebral joints. In all patients it was possible to relate the areas of increased uptake to specific anatomical sites of the spine known to be affected in the different conditions. A detailed localisation is rarely possible using planar scintigraphy alone, due to the complex osseous anatomy of the spine. In some patients lesions could be seen only with SPECT. SPECT is an invaluable supplement to planar scintigraphy of the spine.


Die Einzelphotonen-Emissions-Computertomographie (SPECT) bei Patienten mit benignen und malignen Erkrankungen der Wirbelsäule

August 1986

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13 Reads

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5 Citations

RöFo - Fortschritte auf dem Gebiet der R

Die Bedeutung der SPECT im Rahmen der Skelettszintigraphie wurde bei 54 Patienten mit degenerativen, entzündlichen, traumatischen und malignen Wirbelsäulenerkrankungen untersucht. Die räumliche Auflösung der Methode ist ausreichend, um Wirbelkörper, Wirbelkanal und Wirbelbögen und die verschiedenen Gelenke voneinander zu unterscheiden. Bei allen Patienten konnten mit der SPECT pathologische Anreicherungen bestimmten Strukturen der Wirbelsäule zugeordnet werden. Dies ist mit der konventionellen zweidimensionalen Szintigraphie allein nicht möglich, da hierbei die Wirbelsäule lediglich von dorsal beurteilt wird. Bei mehreren Patienten waren pathologische Veränderungen nur mit der SPECT, jedoch nicht mit der planaren Szintigraphie nachweisbar. Nach unseren Erfahrungen ist deswegen die SPECT eine wichtige Ergänzung der konventionellen Skelettszintigraphie. Summary SPECT has been used in a comparative study with planar bone scintigraphy in 54 patients. Spatial resolution of the method is sufficient to localise the vertebral bodies, the spinous processes, the intervertebral, costotransverse and costovertebral joints. In all patients it was possible to relate the areas of increased uptake to specific anatomical sites of the spine known to be affected in the different conditions. A detailed localisation is rarely possible using planar scintigraphy alone, due to the complex osseous anatomy of the spine. In some patients lesions could be seen only with SPECT. SPECT is an invaluable supplement to planar scintigraphy of the spine.




Treatment of severe Graves' ophthalmopathy with cyclosporin A

January 1986

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9 Reads

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24 Citations

Acta Endocrinologica

Ten patients with severe Graves' ophthalmopathy, resistant to other therapeutic regimens were treated with cyclosporin A (CyA) over a period of 6 months. Clinically, 9 patients improved, 2 of them only after addition of corticosteroids. Intra-ocular tension on upward gaze decreased in all of these 9 patients ( P < 0.01). In 6 patients there was a significant decrease in eye muscle thickness under the treatment ( P < 0.05) as determined by computerized tomography. Side effects (e.g., paraesthesia, proteinuria) which were observed under higher doses of CyA, disappeared after lowering the dose. In only one out of 3 patients with hypertension an antihypertensive medication became necessary. CyA appears to be a valuable drug for treatment of severe Graves' ophthalmopathy when previous therapeutic regimens turned out to be unsuccessful.



Diagnostic investigation of the thyroid gland with image-producing procedures. Part 3: Radiological procedures and NMR tomography

January 1986

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1 Read

For the localisation of retrosternal scintigraphically cold thyroid gland regions, modern X-ray computed tomography offers considerable advantages. In particular in the demonstration of recurrent thyroid gland malignancies, mediastinal lymph node metastases, infiltration into neighbouring tissue, and the narrowing of thoracic vessels, this technique produces excellent results. The evaluation of extraocular muscle infiltration in Graves' opthalmopathy, with the aid of computed tomography, is gaining in clinical importance. The question whether NMR tomography can provide additional information in the diagnostic work-up of thyroid gland diseases, or can replace other image-producing techniques, remains to be seen. The measurement of T1 and T2 relaxation times does not appear to make an unequivocal differentiation between benign and malignant thyroid gland lesions possible.


Brain tumors: Detection and typing by use of CPMG sequences and in vivo T2 measurements

November 1985

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17 Reads

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45 Citations

Radiology

A spin-echo sequence with 24 echoes (Carr-Purcell-Meiboom-Gill sequence) was evaluated to determine the usefulness of magnetic resonance (MR) in detecting and typing brain tumors. The TEs in these examinations were between 28 and 346 msec, and the TR was 860, 1260, or 1660 msec. The results of the MR examination of 32 histopathologically proved tumors are presented. All but one tumor could be detected by MR. Tumors generally were obvious on MR due to the higher contrast enhancement of these lesions, especially with a TE longer than 100 msec. T2 values calculated from an eight-point fit, however, did not allow discrimination of different tumors, nor did they allow differentiation between tumor, inflammatory tissue, and demyelination.


[Skeletal manifestations of generalized mastocytosis in the skeletal scintigram compared with roentgen findings].

June 1985

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7 Reads

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5 Citations

RöFo - Fortschritte auf dem Gebiet der R

Bone scans and skeletal x-rays of eight patients with systemic mastocytosis were reviewed. Mast cell infiltration of bone marrow had been proven histologically in every patient. Bone scan and roentgenographic findings are not specific for the disease and do not correlate well in some patients. A generalized increase of uptake was noted in two patients, a generalized decrease of skeletal activity with poor delineation of bony structures was observed in others. A circumscribed increase of activity was observed in some patients, only one patient had a normal bone scan. Roentgenographic examination revealed diffuse sclerosis of trabecular bone in three patients, osteoporosis with collapse of multiple vertebral bodies in three patients, and no abnormalities in two patients.


[Use of long spin-echo sequences for imaging demyelinating diseases].

May 1985

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5 Reads

RöFo - Fortschritte auf dem Gebiet der R

A multiple spin-echo-sequence has been evaluated in diagnosis of demyelinating diseases. TE in these MR-experiments was between 14 and 336 msec, TR between 860 and 1660 msec. Three groups of patients were examined, and it could be shown that the probability to detect MS-plaques grows with long TE's up to 300 msec. T2-relaxation-time-values range between 126 and 250 msec. Different MS-plaques in the same patient might show different T2-values.


Citations (3)


... Although T2-weighting demonstrated lesions best, sometimes, particularly in the brainstem and cerebellum , proton-weighted images were superior. In agreement with some other authors , we believe that long TEs up to 100 or 120 msec are best at enhancing the affected regions [11,32]. ...

Reference:

MR imaging in multiple sclerosis: Comparison with clinical, CSF, and visual evoked potential findings
Einsatz von langen Spinechosequenzen zur Darstellung demyelinisierender Erkrankungen
  • Citing Article
  • April 1985

RöFo - Fortschritte auf dem Gebiet der R

... In the study, the following investigations were done in all patients which includes blood routine examination, urine routine examination, blood sugar, blood urea, serum creatinine, plain x-ray neck, chest x-ray, indirect laryngoscopy and Fine Needle Aspiration Cytology. 47,48,49 Most of the patients had done ultrasonogram of neck. 50 All the patients had their thyroid function tests-T3, T4 and TSH done before and after surgery. ...

[What is nuclear medicine?]
  • Citing Article
  • April 1985

Krankenpflege Journal

... MRI has been known as a powerful noninvasive tool on the medical field due to its unique features. Two quantities potentially in MRI indicating the important information on the objects are longitudinal (T 1 ) and transverse (T 2 ) relaxation times [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. A lot of the statistical and dynamical parameters can vary these times. ...

Brain tumors: Detection and typing by use of CPMG sequences and in vivo T2 measurements
  • Citing Article
  • November 1985

Radiology