E. Seigneuret's research while affiliated with Université Grenoble Alpes and other places

Publications (53)

Article
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for motor complications in Parkinson disease (PD). Since 2012, the nonrechargeable dual-channel neurostimulator available in France seems to have shorter battery longevity compared to the same manufacturer's previous model. Objective: The ai...
Article
We examined executive functioning in patients with Parkinson's disease exhibiting, or not, levodopa-resistant freezing of gait (L-FOG). 38 advanced-stage patients with L-FOG were identified in a consecutive series of 400 patients. They were matched with 38 patients without L-FOG. All patients underwent prospective evaluations of cognitive and motor...
Article
Stimulation of the subthalamic nucleus (STN) improves the cardinal features of Parkinson disease (PD). However, its efficacy on gait disorders is less satisfying in the long term. In recent years, the pedunculopontine (PPN) nucleus has emerged as a possible promising deep brain stimulation target for gait disorders in PD. In this review, we examine...
Article
In advanced Parkinson's disease, several therapeutical option including not only lesional surgery (VIM, GPi) and deep brain stimulation (STN, GPi, VIM) but also continuous subcutaneous apomorphine infusion therapy can be proposed to the patient. The choice depends on the hope of the patient, patient's general health condition and the experience and...
Article
Full-text available
L’IRM morphologique tient une place essentielle dans la prise en charge des syndromes parkinsoniens qui demeurent une cause importante de handicap. Alors que l’IRM est habituellement normale dans la maladie de Parkinson, elle montre de façon fréquente des anomalies qui orientent vers ses principaux diagnostics différentiels, étayés par l’examen cli...
Chapter
The history of stereotaxy is part of a larger perspective of a methodological approach that is therapeutic and focuses on the search for precision. The search for precision implies the recognition and marking of targets (taxonomic version of the etymology of the word Stereotaxy, from taxis: order) as well as to the tactic act, which is the achievem...
Chapter
The discovery in 1987 of the effects of stimulation at high-frequency able to mimic in a reversible and adjustable manner the effects of local destruction of functional targets has revived the functional neurosurgery of movement disorders, and currently other fields of functional neurosurgery such as psychosurgery. VIM thalamotomy allowed demonstra...
Chapter
It is generally agreed that stereotaxy was invented in 1905 by Horsley and Clarke [1] who needed an accurate tool for electrode insertion and lesion making in laboratory animals. This laboratory equipment was later adapted for neurosurgical purposes by Spiegel and Wycis in 1947 [2], although the first human stereotactic apparatus was probably built...
Article
Parkinsonian syndromes are a major cause of disability in the elderly. MRI has a key role in the management of the patient. Usually normal in Parkinson disease, conventional MRI may show abnormalities related to neurodegenerative diseases (multi-systemic atrophy, progressive supra-nuclear palsy…) or secondary to numerous disorders such as hypoxia,...
Article
Objectifs Identifier les mécanismes physiopathologiques des altérations des activations péritumorales en IRM fonctionnelle (IRMf). Matériels et méthodes Vingt-et-un patients opérés d’une tumeur cérébrale primitive frontale ou pariétale, respectant le cortex sensori-moteur primaire (gliome de bas grade (n = 6), de haut grade (n = 6), méningiome (n...
Article
The surgical treatment of intractable epilepsies involving eloquent areas of the cortex is still challenging. Deep-brain stimulation could be an alternative to resective surgery because it can modulate the remote control systems of epilepsy, such as the thalamus and basal ganglia. The surgical experience acquired in the field of movement disorder s...
Article
Temporal lobe epilepsy (TLE) is the most common form of intractable partial epilepsy in adults. Surgery (lobectomy or amygdalohippocampectomy) is effective in most patients. However, some complications can occur and brain shift, hematoma into the post operative cavity and occulomotor nerve palsy have been reported due to the surgical technic. We re...
Chapter
Do we have a model? High frequency and low frequency excite axons passing by the stimulation site while low frequency excites the cell bodies. HFS inhibits neuronal firing and may jam the neuronal messages, whether they are normal or wrong. Axons originating from the stimulated neurons convey spikes drifting to the cell bodies as well as to the syn...
Article
An abstract is unavailable. This article is available as HTML full text and PDF.
Article
The purpose was to describe the characteristics of patients whose epilepsy changed after temporal lobe surgery and to discuss the possible mechanisms. Among the 150 patients operated between April 1989 and May 2001 and having a complete follow-up, epilepsy changed after surgery in 35 patients. We excluded 9 patients having had less than 5 seizures...
Article
High frequency stimulation (HFS) has become the main alternative to medical treatment, due to its reversibility, adaptability, and low morbidity. Initiated in the thalamus (Vim) for the control of tremor, HFS has been applied to the Pallidum (GPi), and then to the subthalamic nucleus (STN), suggested by experiments in MPTP monkeys. STNHFS is highly...
Article
Robots are the tools for taking advantage of the skills of computers in achieving complicated tasks. This has been made possible owing to the "numerical image explosion" which allowed us to easily obtain spatial coordinates, three dimensional reconstruction, multimodality imaging including digital subtraction angiography (DSA), computed tomography...
Conference Paper
Abstracts of the Proceedings of the XVIIth Congress of the European Society for Stereotactic and Functional Neurosurgery (ESSFN), Montreux, Switzerland, October 4–7, 2006
Article
Many different surgical procedures are performed for medically refractory partial epilepsy. Some surgical therapies are performed to cure the epilepsy (for example unifocal epilepsy), others are palliative procedures. To cure epilepsy, temporal lobectomy is the most common surgical procedure. The different techniques are shortly described, indicati...
Article
Many different surgical procedures are performed for medically refractory partial epilepsy. Some surgical therapies are performed to cure the epilepsy (for example unifocal epilepsy), others are palliative procedures. To cure epilepsy, temporal lobectomy is the most common surgical procedure. The different techniques are shortly described, indicati...
Article
Facial grimaces or clonic contortions of one side of face and chewing at onset of partial seizures are of great localizing value. Ictal semiology of others buccal movements are more difficult to describe and localize. The patient, a 38-year-old left-handed woman, had seizures with unusual buccal movements (no chewing, nor lipsmacking, nor simple mo...
Article
Full-text available
This paper presents the principle of multimodal and multi-informational neuronavigation as well as the data fusion environment we have developed for these techniques. Our fusion environment supports the planning step and includes registration, segmentation, 3D visualisation as well as data browsing and interaction tools. We provide a neuronavigatio...
Article
A new concept of stereotactic room based on multimodality images is presented. All images are obtained with standard state-of-the-art X-ray vascular suite and MR 1.5 T imager. Several problems due to the use of digital images obtained in a non-dedicated X-ray angiography room have been solved. Moreover, an innovative software package for surgery pl...
Article
In multimodal image-guided neurosurgery, surgeons have to manage large amounts of information (i.e. images) to plan and perform the surgical procedure. To facilitate management we attempted to model the procedure as a set of distinct steps with a UML class diagram. To each step we assigned a list of relevant image entities extracted from multimodal...
Article
Compared to postictal headaches, headaches of epileptic origin are rare. We report three cases studied with depth electrodes. The clinical expression of the headache seemed to be related to the seizure focus. A 16-year-old woman, with a left frontal epilepsy (F1-F2 sulcus) of unknown aetiology, presented with bitemporal headaches as the first manif...
Article
We report the case of a patient, born in 1964, without any particular medical history, suffering from drug resistant epilepsy since the age of 20. The patient describes an isolated pharyngeal constriction during the minor epileptic seizures. During the most severe seizures, this discomfort is followed by a sensation of a progressive motor and verba...
Article
Neurological disease with polymorphic manifestations, partial epilepsy can be cured by surgical treatment. We tried to assess the benefits of such operation for the patient not only on the seizure but also on everyday life. Method: 19 patients with a pharmacoresistant and chronic partial epilepsy were examined before surgery and 6 months later. Tes...
Article
Full-text available
A new concept of stereotactic r oom based on multimodality images is presented. All i mages are o btained with standard state-of-the-art X-ray v ascular suite and MR 1.5 T imager. Several problems due to the use o f digital i mages obtained in a non-dedicated X-ray angiography room have been solved. Moreover, an innovative software package for surg...
Article
Stereotactic thalamotomy of the VIM (ventral intermediate) nucleus is considered as the best neurosurgical treatment for Parkinsonian and essential tremors. However, this surgery, especially when bilateral, still presents a risk of recurrence and neurological complications. We observed that acute VIM stimulation at frequencies higher than 60 Hz dur...

Citations

... Battery longevity depends on stimulation parameters, hardware, and patient factors (Bin-Mahfoodh et al., 2003;Fisher et al., 2018;Sette et al., 2019). Patient factors, such as reliability of IPG recharging or consistency of nightly device shutoff, if appropriate and tolerated (e.g., essential tremor, pain), may affect battery longevity. ...
... However, neurotransplantation remains amongst the best in a limited repertoire of options for symptoms originating from outside the basal ganglia. Although promising results have been reported from PPN deep brain stimulation (DBS) in a cohort of six patients, with major improvements in gait and posture in one PD patient at 1 year follow up and moderate improvements in four oth- ers [77], the procedure is still not widely performed. Meanwhile, L-dopa therapy is ineffective for treating gait and axial symptoms of PD whilst producing distressing side effects. ...
... The main features of 15 published cases affected by ''pure epileptic headache'' [15][16][17][18][19][20][21][22][23][24][25] are reported in Table 2. In the table, no data are provided for the first patients reported with epileptic headaches, [26][27][28][29] as the full text articles are unavailable. ...
... Les auteurs signalent l'apport thérapeutique des techniques cognitives sur la qualité de vie des patients. Un tel apport a également été observé sur la base de tests de personnalité dans d'autres pathologies chroniques tels que la lombalgie [17,18], l'épilepsie [19], les dermatoses [20], les maladies chroniques de l'intestin [21] et les pathologies chroniques de l'enfant [22]. Dans notre étude, seulement une patiente de 72 ans présentait une échelle L > 70 tout en présentant également des valeurs F et K supérieures à 70 ce qui rendait ce dossier non valide. ...
... 151 For these reasons, the hypothalamus is the current target for DBS in the treatment of CH. [152][153][154] New targets have also been proposed, including the ventral tegmental area of the midbrain, the lateral wall of the third ventricle, and floating electrodes that stimulate the floor of the third ventricle. [155][156][157][158][159][160] Technique. The procedure is performed on patients selected according to strict criteria. ...
... Deep Brain Stimulation (DBS) is for the last two decades an alternative treatment of drug-resistant psychomotoric disorders, mainly Parkinson's disease (Tronnier, Fogel et al. 2002;Krause, Fogel et al. 2004;Deuschl, Schade-Brittinger et al. 2006;Benabid, Chabardes et al. 2009;Coffey 2009). Several approaches exist to use this technique also for treatments in cases of chronic pain syndrome, dystonia, Tourette syndrome, epilepsy or depression (Krause, Fogel et al., 2006;Kupsch, Benecke et al., 2006;Rasche, Rinaldi et al. 2006;Bajwa, de Lotbiniere et al. 2007;Chabardes, Minotti et al. 2008;Larson 2008;Mohr 2008;Mueller, Skogseid et al. 2008). Core of the procedure is the insertion of a stimulating electrode into the dysfunctional brain area. ...
... Several weeks following the procedure, the IPG is programmed by a neurologist to determine the optimal settings, with voltage, amplitude and pulse width usually manipulated. 3,4 DBS is being used for increasingly wide applications. It is most commonly used for movement disorders such as Parkinson's disease, essential tremor and dystonia when medical treatment is ineffective or causes intolerable adverse effects. ...
... An often unrecognized agency of damage is the implantation of electrodes in brain. In a recent retrospective study of deep brain stimulation (DBS) electrodes in more than 500 patients, Benabid et al. [65] reported overall implantation-induced complication rates of 14% for temporary confusion and 13% for bleeding. In addition to these overt complications, more subtle functional changes independent of stimulation are regularly observed and reported in clinical settings from Parkinson's disease (PD) to epilepsy [66]. ...
... [10] Despite its increased prevalence in later disease stages, [11,12] multiple studies suggest that the pathophysiology of FOG is different from that of other motor symptoms, which typically worsen with disease progression [12][13][14]. The development of FOG in advanced disease is often associated with symptoms in non-motor domains [15], including executive functioning [16], while its severity does not necessarily correlate closely with the progression of motor symptoms [7,12]. Additionally, FOG has been observed in other neurological conditions including normal pressure hydrocephalus, vascular parkinsonism, and progressive supranuclear palsy, further suggesting that its pathophysiology is not specifically connected to classic motor symptoms of PD [9]. ...