E. N. Tumaev’s research while affiliated with Kuban State University and other places

Based on the classical quantum-mechanical approach, the physical mechanism of isotope fractionation is proposed associated with the predominance of a certain number of neutrons among nucleons and explaining the nonequilibrium accumulation of certain stable isotope shapes of biogenic elements in heterogeneous systems. The effect may be due to the interaction of the magnetic moments of atomic nuclei and valence electrons leading to a change in the distance between them, including the influence of the changed distance between atoms, on the energy of the covalent link between the pairs of atoms.

The physical regularities that lead to isotope fractionation and to the accumulation of certain isotope forms in the intercellular and intracellular space at various levels of biological objects were studied. A new hypothesis of fractionation of stable isotopes in biological objects through the neutron effect was discussed. The following feature is noted: it is very likely that the development of isotope shock in living beings is observed mainly in the presence of covalent bonds between atoms with an uncompensated neutron. One possible explanation for this phenomenon can be associated with a change in the physical parameters of the following events: the interactions of the magnetic moments of valence electrons with the magnetic moments of atomic nuclei and the interactions of magnetic moments of atomic nuclei, which result in a change in the distance between atomic nuclei.

In this paper, we discuss experimental data obtained during study of the effect of a low-frequency alternating magnetic field on the conformational transitions of human serum albumin in the presence of silver nanoparticles using fluorescence spectroscopy at different pH values. A sharp increase in the albumin fluorescence intensity was detected in the presence of silver nanoparticles; this effect changed when exposed to a low-frequency alternating magnetic field. The resulting calculation formula for cross section of light scattering by a spherical nanoparticle of a certain radius allows calculation of the sizes of nano-microstructures based on nanoparticles and natural biopolymers of the “core–shell” type, whose physicochemical properties can be controlled by a magnetic field. The proposed model for the formation of protein–nanoparticle associates in the solution by the dipole–dipole mechanism is in good agreement with the experimental data.

In this paper, on the basis of the classical quantum-mechanical approach, an explanation is considered of the physical mechanism of isotope fractionation associated with the predominance of a certain number of neutrons among nucleons and explaining the nonequilibrium accumulation of certain forms of stable isotopes of biogenic elements in heterogeneous systems. The reasons for the detected neutron effect can be: the interaction of the magnetic moments of atomic nuclei and valence electrons, leading to a change in the distance between them, including the effect of the changed distance between atoms on the energy of the covalent bond between the resonant pairs of atoms.