E Finkelfarb's scientific contributions

Publications (4)

Article
The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by ?9-TCH in normal volunteers, and whether this effect occurs by a general block of the action of ?9-TCH or by a specific anxiolytic effect. Appropriate measurements and scales were utilized and the eight volunteers received, the following treatments...
Article
Full-text available
The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements and scales were utilized and the eight volunteers received, the following t...
Article
Full-text available
Rats, trained to discriminate between delta 9-THC (5 mg/kg) and a control solution, using a T-maze, were submitted to generalization tests wih delta 9-THC (2.5 and 1.25 mg/kg), CBD (40 mg/kg) and the mixtures of delta 9-THC (5 and 1.25 mg/kg) with CBD (40 mg/kg). Doses of delta 9-THC smaller than the training dose, produced a progressive reduction...
Article
Three groups of rats (A, B, C) were trained in a T-maze discriminate between drug-and control solution-induced internal discriminative stimuli. The drugs used to induce discriminative stimuli were: delta 9-THC, 5.0 mg/kg (Group A); ethanol, 1.2 g/kg (Group B), and amphetamine, 1.0 mg/kg(Group C). After discrimination acquisition several drugs were...

Citations

... monomers. As for cannabinoids, they can be also classified as terpenophenolic compounds, which are biosynthesized from the phenolic acid, olivetolitic acid and the monoterpene geranylpyrophosphate. Until now, more than 100 phytocannabinoids have been identified, most of them have demonstrated potential benefits, such as antiepileptic, analgesic, neuroprotective and anticonvulsant efficacy (Harris et al., 2016;Reddy, 2016;Yamaori et al., 2011;Zuardi et al., 1982). In particular, due to the larger number of cannabinoids involved in real samples, the fast and sustainable approach reported in the previous section can be considered just preliminary and an untargeted characterization is needed, by exploiting the MS signals for the identification of unknown peaks for which commercial standards are not available. ...
... A few studies have examined effects of cannabinoid drugs in animals trained to discriminate EtOH. The general con sensus is that rodents show no generalized responding to these drugs, and there is no blockade of EtOH dis crimination by Δ9THC (Bueno, Carlini, Finkelfarb, & Suzuki, 1976;Jarbe, 1977). In animals trained to discrimi nate Δ9THC or methanandamide, no evidence of gen eralized responding to EtOH was observed (Bueno et al., 1976;Jarbe, Li, Vadivel, & Makriyannis, 2010;McMahon, Ginsburg, & Lamb, 2008). ...
... 1 These disorders include multiple sclerosis, bipolar disorder, amyotrophic lateral sclerosis (ALS), Huntington's, Alzheimer's, and Parkinson's disease, which result in the loss of the structure or function of neurons. [2][3][4][5][6][7][8][9] Although various genetic and environmental factors initiate disease-specific pathophysiology, common underlying mechanisms ultimately mediate the progressive loss of neuronal structure and function as a result of cell death. ...
... En el terreno de la psiquiatría, estudios preclínicos y clínicos sugieren que el CBD tiene efectos antipsicóticos, ansiolíticos y antidepresivos, por lo que se ha considerado como una opción dentro de una amplia gama de trastornos neuropsiquiátricos 8 . El CBD ha mostrado eficacia en estudios preclínicos como monoterapia o coadyuvante en tratamientos en animales y humanos, en modelos de psicosis 9,10 , en ansiedad [11][12][13][14][15] , en depresión 16 , en adicciones 16 y en insomnio 17 . ...