E. C. Zeeman's research while affiliated with The University of Warwick and other places

Publications (2)

Article
Most current models for morphogenesis of repeated patterns, such as vertebrate somites, cannot explain the observed degree of constancy for the number of somites in individuals of a given species. This precision requires a mechanism whereby the lengths of someites (i.e. number of cells per somite) must adjust to the overall size of individual embry...

Citations

... Studies on temporal control of cell cycle progression, circadian rhythm, and segmentation have frequently converged on the concept of biological oscillators [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . Biological oscillators are systems of molecules with various levels of expression and activity that act as molecular "clocks" that determine biological rhythms resilient to changes in external environments. ...
... In 1976, Cooke and Zeeman proposed a theoretical model that aimed to explain the formation of periodic structures during vertebrate development. In their Clock and Wavefront model (Cooke and Zeeman, 1976), the authors proposed the existence of two players: a molecular oscillator (clock), responsible for the rhythmic generation of a cell responsive state, and a maturation wavefront, moving slowly in an anterior-to-posterior direction. Exposure of a clock-induced cell population to the wavefront signal would promote a rapid change in cell properties, leading to the formation of a somite. ...